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AFPE Fellows are conducting research in important areas

Cardiovascular and Pulmonary

  • Acute Coronary Syndrome
  • Arrhythmia
  • Atrial Fibrillation
  • Cardiovascular Disease
  • COPD
  • Delta Storage Pool Deficiencies; Thrombocytopenia
  • Heart Failure
  • Ischemic Stroke
  • Lung Disease
  • Thrombosis

Drug Delivery

  • Degenerative Diseases with Mitochondrial Dysfunction
  • Liposomal Drug Delivery
Drug Interactions and Medication Adherence
  • Herb-Drug Interactions
  • Medication Adherence in Renal Patients

 

Oncology

  • Brain Cancer
  • Breast Cancer
  • Colorectal Cancer
  • Ewing's Sarcoma
  • Lung Cancers
  • Non-Hodgkin's Lymphoma
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Renal Cell Carcinoma 
Obesity and Diabetes
  • Cardiovascular Disease & Metabolic Syndrome
  • Gestational Diabetes Mellitus (GDM)
  • Obesity
  • Obesity-related Diseases such as Type 2 Diabetes
  • Type 2 Diabetes and Mental Health

Geriatrics and Associated Conditions

  • Alzheimer's Disease
  • Geriatric Pharmacy
  • Neurodegenerative Disorders
Miscellaneous
  • Alcohol Use Disorders
  • Epilepsy
  • Inflammatory Disease
  • Methamphetamine Abuse
  • Multiple Sclerosis and other Autoimmune Diseases
  • Neuropathic Pain; Allodynia
  • Osteoarthritis; Avascular Necrosis; Rheumatoid Arthritis
  • Physical and Biopharmaceutical Properties of Model Compound Drugs
  • Translational Research

Value of the Pharmaceutical Sciences

 Pharmaceutical scientists trained at U.S. schools and colleges of pharmacy are working on breakthrough technologies made possible by combinatorial chemistry, in vitro biopharmaceutical techniques, analytical technologies, bio-materials, and gene transfers-gene therapies such as:

  • Accelerated chemical synthesis and biological screening of millions of compounds to identify as well as optimize structurally novel drug candidates
  • Molecular-based assays using cloned enzymes to predict how the body will metabolize a promising drug candidate before large investments are made in development and animal testing

     

  • Using cloned metabolizing enzymes or human tissue to analyze and predict toxicity problems and other associated costs prior to a drug's clinical investigation
  • Implantation or injection of large molecules that are biocompatible over long periods of time to allow delivery of medication at controlled rates over the full course of therapy
  • Providing a gene therapy in a stable form, targeted to a specific site, in a safely administered dosage system
Fundamental changes in drug discovery and development brought about by these new technologies are impacting graduate education in the pharmaceutical sciences both in the graduate curriculum and the research environment. The pharmaceutical sciences disciplines at U.S. college of pharmacy graduate schools include:
  • Clinical Pharmaceutical Sciences: the study of drug therapy outcomes in patients with emphasis on factors & mechanisms determining therapy outcomes; the study of genetic & non-genetic factors in the variability of drug response; the study of human pharmacology & therapeutics to improve safe, effective & economical use of medications by patients; and the optimization of drug therapy through generation, integration, & translation of scientific knowledge between the bench and the bedside.

     

  • Economic, Social, and Administrative Sciences: the economic analysis of pharmaceuticals, pharmaco-economic protocol development, pharmaceutical outcomes research, disease management protocols and processes, and management of pharmacy systems and organization

     

  • Medicinal/Pharmaceutical Chemistry: the design and synthesis of chemical/organic compounds with biological activity and potential use in treatment of disease

     

  • Natural Products Chemistry/Pharmacognosy: the analysis, biosynthesis, production, metabolism, and mechanisms of action of pharmaceutically important plants, animals, and microbes

     

  • Pharmaceutics: the design, fabrication, and evaluation of advanced drug delivery and advanced drug level management systems

     

  • Pharmacology: the use of genetic, molecular, cellular, organ system, and whole animal techniques to examine mechanisms and consequences of drug interactions with living systems

     

  • Toxicology: the analysis of adverse effects of new biologically active compounds on living systems, such as tissue injury, reproductive failure, immunosuppression, and cancer