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2002-03 Pre-Doctoral Fellow Profiles

MINOLI A. PERERA
Ohio State University College of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.95/4.00
Expected Graduation: December 2003
Focus of Research: The pharmacokinetics and metabolism of novel non-steroidal androgen receptor modulators (SARMs). In addition, determination of the biodistribution and tissue concentrations of these SARMs will help ascertain the in vivo androgen receptor modulator.
Title of Dissertation: “Pharmacokinetics and Metabolism of Androxolutamide, a Novel Non-Steroidal Selective Androgen Receptor Modulator.”
Degrees Received: Pharm.D., University of Tennessee, May 2001
B.S., Biology, Christian Brothers University, May 1997 (Summa Cum Laude)
Honors Received: 1998, Merck Scholar; 1997, 1st Place Tennessee Academy Science; 1993-1997, Dean’s List; 1993, Presidential Scholarship; 1993, Memphis City Council Service Award
AFPE Award JOSIAH KIRBY LILLY SR. Memorial Fellowship in the Pharmaceutical Sciences

QUENTIN HOA L. PHUNG
University of Oklahoma College of Pharmacy
Major: Social & Administrative Sciences (Marketing)
GPA: 3.83/4.00
Expected Graduation: May 2004
Focus of Research: To analyze consumers’ perception of pharmacy. The research objective is to determine how to re-focus consumers’ perception of the pharmacy to that of a service-oriented industry. The research project will study how pharmacists can better market themselves to all stakeholders as an integrative service provider.
Title of Dissertation: “Effects of the Patient-Physician Relationship Due to Interactions with a Disease State Management Pharmacist Based Program.”
Degrees Received: B.S., Pharmacy, University of Oklahoma, May 1999
Honors Received: 1999, Lilly Achievement Award; 1999, Roche Pharmacy Communication Award; 1999, Merck Outstanding Research and Scholastic Excellence Award; 1999, ASHP’s Counseling Contest Winner; 1998, Stanford Scholarship Recipient; 1997, Rho Chi Outstanding Academic Award; 1994, Honors Scholarship Recipient
AFPE Award NACDS-AFPE Association Fellowship in Social & Administrative Sciences

KATHLEEN I. SEYB
University of Kansas School of Pharmacy
Major: Pharmacology/Toxicology
GPA: 3.71/4.00
Expected Graduation: May 2005
Focus of Research: Oxidative damage and a loss of intracellular calcium homeostasis have been observed in both aging and Alzheimer’s Disease. This research is focused on the effects of oxidative modifications to the sacro/endoplasmic reticulum calcium ATPase on maintaining intracellular calcium homeostasis and the initiation of apoptosis.
Title of Dissertation: “Oxidative Modification to the Sacro/endoplasmic Reticulum Calcium ATPase and the Maintenance of Intracellular Calcium Homeostasis in Aging and Alzheimer’s Disease.”
Degrees Received: B.S., Chemistry, University of Memphis, August 2000
Honors Received: 2000-Present, Bishop Graduate Scholarship; 2000, Chi Beta Phi Award for Excellence in Chemistry; 1996-2000, Cecil B. Humphrey Presidential Scholarship
AFPE Award NWDA-AFPE Association Fellowship in the Pharmaceutical Sciences

JARED T. SPLETSTOSER
University of Kansas School of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 3.65/4.00
Expected Graduation: May 2004
Focus of Research: The manipulation of taxoid chemotherapeutics to permeate the blood-brain barrier. Specifically, to reduce the affinity of Taxol analogs toward the p-glycoprotein efflux system. Additionally, the use of azide-base photo affinity labels to effectively probe the Taxol/tubulin interaction site.
Title of Dissertation: “I. The Development of Novel Taxoids with Reduced Affinity Towards P-Glycoprotein for Delivery to the Brain II. Photoaffinity Taxoids to Probe the Tubulin Binding Site.”
Degrees Received: B.S., Cytotechnology, University of North Dakota, August 1999
Honors Received: 2002, Groetsch Pre-Doctoral Fellow; 2000, Dept. of Defense Breast Cancer Fellow; 1999, NASA-JSC Micro-Gravity Research Participant; 1994-1999, BNI Coal Scholarship; 1998, National Dean’s List; 1997 Honor Marshal-University of North Dakota; 1997, UND Athletic Director Academic Achievement Award; 1996, Thomas D. Campbell Scholarship; 1995, Maxwell Upson Scholarship; 1994/1997, UND Dean’s List
AFPE Award AFPE Fellowship in Medicinal/Pharmaceutical Chemistry

BARBARA R. SPONG
University of Michigan College of Pharmacy
Major: Pharmaceutics
GPA: 7.03/9.00
Expected Graduation: December 2003
Focus of Research: This research is aimed at determining the role of molecular level events on the crystallization mechanisms of HIB protease inhibitors. Specifically, the effect of drug-drug and drug-excipient interactions, pH, solvents, and biological surfactants will be investigated. In addition, the occurrence of polymorphs will be screened under controlled environmental conditions. Our goal is to correlate molecular level events to changes in crystal structures and surfaces, thus showing the impact on solid-phase outcomes such as drug bioavailability.
Title of Dissertation: “Molecular Level Effects of pH, Solvents, and Additives on the Crystallization and Polymorphism of HIV-Protease Inhibitors.”
Degrees Received: M.S., Pharmaceutical Sciences, University of Michigan, April 2001
B.S., Pharmacy, Rutgers University-College of Pharmacy, May 1998
Honors Received: 2000-2001, AFPE Pre-Doctoral Fellowship; 2001, USP Fellowship; 2000-2001, Fred W. Lyons, Jr. Fellowship; 1998, GEM Ph.D. Science Fellowship; 1995-1998, Merck Manufacturing Division Minority Engineering Fellowship
AFPE Award GLAXOSMITHKLINE-AFPE Fellowship in Manufacturing/Industrial Pharmacy

ANJALI SRINIVASAN
University of Michigan College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 7.18/9.00
Expected Graduation: May 2003
Focus of Research: To probe the mechanism of the enzyme, oligosaccharyl transferase (OST), using alpha secondary kinetic isotope effects via a biotin capture assay.
Title of Dissertation: “Exploring the Electrophilic Activation Mechanism of Oligosaccharyl Transferase.”
Degrees Received: B.S., Biological Chemistry, University of Chicago, June 1997
Honors Received: 2000, Vahlteich Research Award; 2000, AFPE Pre-Doctoral Fellowship; 1999, Pharmaceutical Sciences Training Grant
AFPE Award AAPS-AFPE Association Fellowship in the Pharmaceutical Sciences

JEFFREY A. SUNMAN
Mercer University Southern School of Pharmacy
Major: Pharmacology/Toxicology
GPA: 4.00/4.00
Expected Graduation: May 2003
Focus of Research: The enzyme peptidyglycine alpha-monooxygenase (PAM) is the rate-limiting enzyme in the activation of several inflammatory and growth-regulating peptides. My research evaluates 2 inhibitors of PAM as anti-inflammatory and anti-tumor agents.
Title of Dissertation: “Anti-Inflammatory and Anti-Tumor Properties of Two Inhibitors of Peptide Amidation.”
Degrees Received: B.S., Biology, Stetson University, May 1998
Honors Received: 2001, AFPE Pre-Doctoral Fellowship; 2001 SEPS Greenbaum Student Research Award in Pharmacology; 1999-2002, Mercer Dean’s List
AFPE Award USP-AFPE Association Fellowship in Pharmacology/Toxicology

MICHAEL D. TAYLOR
University of Florida College of Pharmacy
Major: Social & Administrative Pharmacy (Pharmacy Health Care Administration)
GPA: 3.94/4.00
Expected Graduation: May 2004
Focus of Research: Outcomes research with a particular emphasis in the area of pharmacoeconomics. This research project will develop models to determine the cost-effectiveness of pharmaceuticals in treating various chronic and acute disease states.
Title of Dissertation: “Conversion of SF-36 Quality of Life Responses into Utility Scores.”
Degrees Received: Pharm.D., University of Florida, May 2001 (High Honors)
Honors Received: 2001, Rho Chi-Schering-Plough-AFPE First Year Graduate Scholarship; 2001, University of Florida Alumni Fellowship; 1997-2001, Dean’s List; 1999, Rho Chi Pharmacy Honor Society
AFPE Award JANSSEN PHARMACEUTICA-AFPE Fellowship in Social & Administrative Sciences (Pharmacoeconomics)

JOHN W. TOMSHO
University of Michigan College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 6.98/9.00
Expected Graduation: June 2004
Focus of Research: Determining whether folypolyglutamate synthetase (FPGS) catalyzes the ligation of the glutamate residues in either a processive or distributive fashion using a combination of biochemical and chemical methods.
Title of Dissertation: “Studies into the Reaction Mechanism of Folylpoly-Glutamate Synthetase: Processivity.”
Degrees Received: B.S., Pharmaceutical Chemistry, Philadelphia College of Pharmacy and Science, May 1998
Honors Received: 2001, AFPE Pre-Doctoral Fellowship; 2001-2002, Fred W. Lyons, Jr. Fellowship; 2001, Blake Fellowship; 1998-2000, Chemistry-Biology Interface Fellowship; 1998, Reber Research Award; 1998, De-Lisser Matthews Prize; 1998, American Institute of Chemists Undergraduate Award in Pharmaceutical Chemistry; 1997, American Chemical Society Award for Undergraduate Analytical Chemistry
AFPE Award RICHARD E. FAUST Citation Fellowship in the Pharmaceutical Sciences

JANNINE G. TRUONG
University of Utah College of Pharmacy
Major: Pharmacology/Toxicology
GPA: 3.86/4.00
Expected Graduation: May 2004
Focus of Research: The vesicular monoamine transporter-2 (VMAT-2) is the main protein involved in sequestration of dopamine into vesicles for storage and release. The focus of research is to understand the mechanism whereby VMAT-2 is regulated during development and how psychostimulants alter the regulation of VMAT-2.
Title of Dissertation: “Effects of Psychostimulants on the Vesicular Monoamine Transporter-2 During Development.”
Degrees Received: M.S., Neurobiology, University of Texas-San Antonio, May 2000
B.S., Biology, University of Texas-San Antonio, May 1998
B.S., Chemistry, University of Texas at Austin, December 1996
Honors Received: 1999, UTSA Research Award; 1999, UTSA Small Grant Award; 1999. UTSA Travel Award; 1994-1996, Hemphill-Gilmore Scholarship; 1995, Hoechst Celanese Scholarship; 1993, University Co-op Scholarship; 1991-1993, Tams Gifted Program
AFPE Award SIR HENRY S. WELLCOME Memorial Fellowship in Pharmacology/Toxicology

MAX TSAI
Ohio State University College of Pharmacy
Major: Pharmaceutics
GPA: 3.87/4.00
Expected Graduation: August 2003
Focus of Research: The development and application of a paclitaxel formulation that will be administered locally for the treatment of ovarian cancer.
Title of Dissertation: “Preparation and Application of Paclitaxel Microspheres for the Treatment Against Ovarian Cancer.”
Degrees Received: B.S., Biomedical Engineering, Northwestern University, June 1998
Honors Received: 1999-2001, AFPE Pre-Doctoral Fellowship; 2001, Rho Chi Pharmacy Honor Society; 1998, Dean’s List
AFPE Award WYETH PHARMACEUTICALS-AFPE Fellowship in the Pharmaceutical Sciences

COLIN T. WALSH
Ohio State University College of Pharmacy
Major: Pharmaceutics
GPA: 3.65/4.00
Expected Graduation: January 2004
Focus of Research: This research focuses on research that reports that fibroblast growth factors 1&2 induce broad-spectrum chemoresistance, and that suramin (an FGF inhibitor) reverses this resistance. This research project will focus on improving our understanding of the mechanisms of the FGF-induced resistance and the molecular pharmacodynamics of suramin. Bioinformatic tools will be used to outline the signaling pathways responsible for FGF-induced resistance, and quantitative image analysis tools will be developed to analyze FGF levels in patient tumors to determine the relationship between intratumoral FGF levels and chemosensitivity.
Title of Dissertation: “Molecular Pharmacodynamics of Cancer Chemotherapy: Fibroblast Growth Factor Inhibitors as Chemosensitizers.”
Degrees Received: B.S., Chemical Engineering, University of Kentucky, May 1999
Honors Received: 2001, AFPE Pre-doctoral Fellowship; 2000, Outstanding Teaching Assistant Award (Winter & Spring); 1999, College of Engineering Dean’s List (3-semesters); 1999, Omega Chi Epsilon Engineering Honor Society
AFPE Award ABBOTT LABORATORIES FUND-AFPE Fellowship in Pharmaceutics

SUSAN C. WANG
University of Texas at Austin College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 4.00/4.00
Expected Graduation: May 2003
Focus of Research: The focus of research is the cloning, expression, purification, and characterization of enzymes. This research project will study small molecules as substrates and as reversible and irreversible inhibitors. The research will also investigate the importance of particular residues in catalysis using site-directed mutagenesis.
Title of Dissertation: “Relationship Between the Anti-Serine Protease and Anti-HIV Activities of Secretory Leukocyte Protease Inhibitor (SLPI).”
Degrees Received: B.S., Biology, Case Western Reserve University, May 1998
Honors Received: 2001-2002, University Continuing Fellowship; 2001, AFPE Pre-doctoral Fellowship; 1999, Phi Kappa Phi; 1998, Phi Beta Kappa; 1996, Golden Key National Honor Society; 1996, Case Alumni Association Scholarship; 1994, Case President’s Scholarship; 1994, NASA Scholarship; 1994, National Merit Scholarship
AFPE Award AAPS-AFPE Association Fellowship in the Pharmaceutical Sciences

BRADY N. WARE
University of Georgia College of Pharmacy
Major: Pharmaceutical Sciences
GPA: 4.00/4.00
Expected Graduation: May 2003
Focus of Research: This research addresses the basic question of what portions of the genome encode protein, and how the genome seemingly contains such a small portion of coding sequence yet produces so much protein diversity.
Title of Dissertation: “Potential Modulation of UGA Codon Function.”
Degrees Received: B.S., Biology, Virginia Tech, December 1997 (Summa Cum Laude)
B.S. in Honors, Biochemistry, Virginia Tech, December 1997 (Summa Cum Laude)
Honors Received: 2001, AFPE Pre-doctoral Fellowship; 1998-2000, University Wide Graduate Assistant; 1997-1998, Sigma Xi Undergraduate Research Award; 1997-1998, Who’s Who Among College and Universities; 1996-1997, Cyrus McCormic Merit Scholarship; 1993-1997, Dean’s List
AFPE Award JOSIAH KIRBY LILLY SR. Memorial Fellowship in the Pharmaceutical Sciences

EMILY C. WARE
University of Georgia College of Pharmacy
Major: Pharmaceutics
GPA: 4.00/4.00
Expected Graduation: August 2003
Focus of Research: Polymeric drug conjugates consisting of a double ester, enzymatically degradable backbone make better drug delivery systems than nondegradable polymers and allow for more effective targeted anti-cancer therapy. This research project will investigate the use of polymeric drug conjugates as a novel film coating and as a site specific, modulated drug delivery system and will explore their potential use in targeted, anti-cancer therapies.
Title of Dissertation: “Synthesis, Characterization, and Formulation of Novel Pharmaceutical Polyesters.”
Degrees Received: B.S., Chemical Engineering, Virginia Tech, December 1997 (Cum Laude)
Honors Received: 2000-2001, Dean’s List; 1997, Engineer in Training
AFPE Award NOVARTIS-AFPE Fellowship in Manufacturing/Industrial Pharmacy

ADAM S. WIDERA
University of Southern California School of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.90/4.00
Expected Graduation: June 2003
Focus of Research: The carrier-mediated delivery of protein based drugs across epithelial barriers. Pulmonary delivery is currently being investigated. An in vitro model for studying the transport properties of alveolar type II cells has been developed via phenotype modification by KGF.
Title of Dissertation: “Transcytosis of Transferrin-Protein Drug Conjugates Across KGF Phenotype-Modified Rat Alveolar Epithelial Cell Monolayers.”
Degrees Received: B.S., Biochemistry, University of California-Los Angeles, December 1995
Honors Received: 2002, CRS Podium Presentation-Korea; 2001, Rho Chi Pharmacy Honor Society; 2000, Vice President- ISC AAPS Chapter; 2000, USC Summer Research Fellowship; 1995, Noble & Ruth Hines Memorial Scholarship; 1994, California Teachers Association Scholarship; 1993, Rotary Club Scholarship
AFPE Award AAPS-AFPE Association Fellowship in the Pharmaceutical Sciences

CHRISTOPHER R. YOUNG
University of Texas at Austin College of Pharmacy
Major: Pharmaceutics
GPA: 3.90/4.00
Expected Graduation: May 2004
Focus of Research: Hot-melt extrusion, a widely applied processing technique used in the plastics industry to produce tubes, pipes, wires, and films, is becoming an area of interest in pharmaceutical research. This method can be used to prepare granules, sustained-release tablets, and transdermal drug delivery systems. The purpose of this research is to develop and to characterize a hot-melt extrusion process to manufacture spherical pellets.
Title of Dissertation: “Properties of Spherical Pellets Produced by Hot-Melt Extrusion and Spheronization.”
Degrees Received: B.S., Pharmacy, University of Texas at Austin, May 1999
Honors Received: 2001, AFPE Pre-Doctoral Fellowship; 1999, Rho Chi-Schering Plough-AFPE First Year Graduate Scholarship; 1999, Pfizer Outstanding Leader Award; 1999, Basic Sciences Outstanding Student Award
AFPE Award NACDS-AFPE Association Fellowship in the Pharmaceutical Sciences

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Profile of Current Winners: A-C, D-H, J-L, M-O, P-Y
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