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2005-06 AFPE Pre-Doctoral Fellow Profiles

NIMA AKHAVEIN
Mercer University Southern School of Pharmacy
Major Pharmacology/Toxicology
GPA: 3.9/4.0
Graduation Date: May-07
Focus of Research: To test if using microspheres made from biocompatible polymers to encapsulate NF-kB transcription factor anti-sense oligonucleotides (ASO) will increase the stability and biological half-life and condense the antisense oligonucleotides so they are more efficiently phagocytosed by cells such as macrophages which play such large role in the production and release of pro-inflammatory cytokines.
Title of Dissertation: “Effect of Microencapsulated Anti-sense Oligonucleotides on Cronic Inflammation associated with Rheumatoid Arthritis.”
Degrees Received: B.A., Psychology, Mercer University, May 2003
Honors Received: 2003, American Association of Pharmaceutical Scientists Induction, Richard Metzger Award for Best Psychology Research, Deans’ List; 2003-2000, Atlantic Sun All Academic Conference; 2000, Trans America Athletic All Academic Conference
AFPE Award: Novartis- AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

JOHN D. BAUER
Mercer University Southern School of Pharmacy
Major Medicinal/Pharmaceutical Chemistry
GPA: 3.56/4.0
Graduation Date: May-07
Focus of Research: To test if modification of the aryl-acetic acid template characteristic of non-selective COX inhibitors to one in which the carboxylic acid moiety is replaced by a sulfonamide substituent will induce selectivity for the COX-II isozyme.
Title of Dissertation: “The Design, Synthesis, and Evaluation of Novel m-Terpheny1-methane sulfonyls as Non-steroidal Anti-inflammatory Agents.”
Degrees Received: B.S., Biochemistry, State University of New York at Binghamton, May 2001
Honors Received: 2004, 1st Place SEPS Platform Presentation, Kappa Psi Pharmaceutical Fraternity Induction; 2004-2003, Patrick J. D’Souza Award; 2003-02, Pharmacy Dean’s Award
AFPE Award: Pfizer, Inc - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

AMY L. BRACKMAN
University of Georgia College of Pharmacy
Major Pharmacology/Toxicology
GPA: 3.86/4.00
Graduation Date: Jun-07
Focus of Research: Examining the hypocholesterolemic actions of sorghum wax by developing animal models to demonstrate the cholesterol lowering capabilities of sorghum wax and to investigate its mechanism of action.
Title of Dissertation: “Grain Sorghum Wax as a Natural Hypocholesterolemic Agent”
Degrees Received: B.S., Chemistry, Georgia College & State University, May 2003
Honors Received: 2005, Most Valuable Teaching Assistant; 2003, Most Valuable Chemistry Major; Lucy Blake Carson Chemistry Scholarship; Kappa Mu Epsilon Fraternity; 2003-1999, Dean’s Honor List
AFPE Award: Consumer Healthcare Products Association - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

EVE E. BRALLEY
University of Georgia College of Pharmacy
Major Pharmacology/Toxicology
GPA: 3.87/4.0
Graduation Date: Aug-07
Focus of Research: To investigate the anti-inflammatory and anti-carcenogenic properties of muscadine grape in diseases of inflammation such as inflammatory bowel disease, and colon cancer.
Title of Dissertation: “The Role of Vitis rotundifolia (Muscadine Grape) as an Anti-Inflammatory, Anti-Carcinogenic Agent in Diseases of Inflammation.
Degrees Received:

C.C.N. Certified Clinical Nutritionist, Clinical Nutrition Certification Board, August 2000
B.S. Nutrition, University of Georgia, December 1998

Honors Received: 2005, Outstanding TA of the Year; 1998, Presidential Scholar; 1996 Phi Omicron Upsilon Honor’s Fraternity; National Golden Key Club;
AFPE Award: Proctor & Gamble Fund - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

IRA S. BUCKNER
University of Iowa College of Pharmacy
Major Pharmaceutics
GPA: 4.0/4.0
Graduation Date: May-07
Focus of Research: A unique compression calcrimeter has been used to determine work and heat changes taking place within powder samples during compaction. Collection of such data has allowed the calculation of internal energy changes associated with the compaction process. Many methods of thermodynamic analysis have been developed and may be applied to characterization of compaction induced energy changes. The focus of the current research is to investigate conollmaniary calorimetric methods for comparison with previous results obtained from the compression calcrimeter.
Title of Dissertation: “Investigations in the Thermodynamic Changes Induced by Compaction of Pharmaceutical Products.”
Degrees Received: B.S., Chemistry, Illinois State University, May 1999
Honors Received: 2004, AFPE Pre-Doctoral Fellowship, Rho Chi Pharmacy Fraternity Induction; 2004-2003, Keith Guillory Graduate Fellowship; 2002, UI Presidential Graduate Fellowship; 2000, Abbott Laboratories Performance Excellence Award; 1998, ACS Undergraduate Analytical Chemistry Award, Hypercube Undergraduate Physical Chemistry Award
AFPE Award: Pfizer Inc. - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

AMY B. CADWALLADER
University of Utah College of Pharmacy
Major Pharmacology/Toxicology
GPA: 3.78/4.00
Graduation Date: May-07
Focus of Research: The hypothesis that the position of functional groups on anabolic and non-anabolic steroids dictates their binding affinity, rate of transport to the nucleus, and transcriptional activity for both the hAR and hGR, and that these characteristics will correlate with the differential degree of anabolic activity observed in whole animals.
Title of Dissertation: “Differentiation of the Cellular Actions of Anabolic and Non-Anabolic Steroids.”
Degrees Received: M.S., Biology, Virginia Commonwealth University, May 2003
B.S. Chemistry/Biochemistry & Molecular Biology, Dickinson College, May 2001
Honors Received: 2004, Society of Toxicology Graduate Student Travel Award, University of Utah Graduate Research Supplement Travel Award; 2003, Willard L. Eccles Merit Fellowship; 2001, Alumni Council Leadership Award, Dickinson College
AFPE Award: Josiah Kirby Lilly, Sr. Memorial - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

RYAN J. CASE
University of Illinois at Chicago College of Pharmacy
Major Pharmacognosy
GPA: 4.8/5.0
Graduation Date: Jun-06
Focus of Research: The research will focus on the documentation of plants used within Manus Province, Papua New Guinea to treat tuberculosis, and assessment of their potential to supplement treatment of tuberculosis through chemical and biological analysis, and finally to improve community awareness of herbal treatment for tuberculosis.
Title of Dissertation: “Scientific Validation of Plants Used By People of Manus Province, Papua New Guinea, to Treat Tuberculosis.”
Degrees Received: B.S., Plant Biology, University of Delaware, January 2001
Honors Received: 2003, Anne Chatham Award, Lloyd Yale Memorial Scholarship; 2001-1997, Carvel State Scholar, Delaware Governor’s Scholarship; 2000, Undergraduate Research Grant; 1999, Outstanding Freshman Academics, Science and Engineering Scholar; 1998, First Year Honors Certificate
AFPE Award: Abbott Laboratories Fund - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

MARCIA L. CHEW
University of Pittsburgh School of Pharmacy
Major Pharmaceutical Sciences
GPA: 3.9/4.0
Graduation Date: Dec-06
Focus of Research: To 1) use the anticholinergic activity (SAA) assay to measure the muscarine receptor binding activity of 110 most commonly prescribed geriatric drugs, 2) to assess the stability of SAA levels across time and whether or not the relationship between SAA and clinical assessments (e.g. cognitive and behavioral) is stable overtime, particularly in individuals suffering from dementia, 3) to use available clinical data to assess which parameters affect cognition and SAA levels, and 4) determine whether pupil dilation, papillary light reflex or accommodation can be used as a peripheral marker in conjunction with SAA to assess central anticholinergic activity.
Title of Dissertation: “Anticholinergic Activity and Cognition in the Elderly.”
Degrees Received: B.S., Molecular Biology, University of Pittsburgh, April 1996
Honors Received: 2005 & 2004, AFPE Pre-Doctoral Fellowship; 2003, Glenn/AFAR Scholarship; 2002, American Association of Pharmaceutical Scientists Membership; 2001 & 2000, Albert Schweitzer Fellowship; 1996 & 1995, Lawler Memorial Scholarship; 1996-92, University Scholarship; 1996-92, Greensburg Italian Women’s Club Scholarship; 1995, Study Abroad Scholarship, Semester at Sea Alumni Scholarship; 1994, Howard Hughes Summer Fellowship, Beta, Beta, Beta Biological Honor Society
AFPE Award: National Association of Chain Drug Stores Foundation - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

PADMANABH CHIVUKULA
University of Utah College of Pharmacy
Major Pharmaceutics
GPA: 3.87/4.0
Graduation Date: May-07
Focus of Research: The use of an oral colon specific hydrogel delivery system for the delivery of bioactive molecules. The research encompasses the synthesis and evaluation of IPN hydrogels composed from pH-sensitive, aromatic azo group containing hydrogel as the first component and a hydrolyzable network as the second component for use in the diagnosis and treatment of colorectal cancer.
Title of Dissertation: “Interpenetrating Hydrogel Networks and their Application in Colon Cancer Imaging and Treatment.”
Degrees Received: B.S., Chemistry, University of Utah, June 2001
Honors Received: 2004, AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences
AFPE Award: Bristol-Myers Squibb - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

PAMELA L. CLEMENS
University of Minnesota College of Pharmacy
Major Experimental & Clinical Pharmacology
GPA: 4.00/4.00
Graduation Date: Jun-06
Focus of Research: The purpose of this study is to characterize the rate and extent of absorption of rectally administered oxcarbazepine compared with oral administration. Tolerability of receiving oxcarbazepine via each route and side effects occurring after each administration will also be compared
Title of Dissertation: “Bioavailability and Metabolism of Rectally Administered Oxcarbazepine Suspension.”
Degrees Received: B.S. Biology, University of Wisconsin – La Crosse, May 2001
B.S. Psychology, University of Wisconsin – La Crosse, May 2001
Honors Received: 2005, Rho Chi Society Induction; 2001, Strzelczyk Award in Science and Allied Health; Outstanding Senior of the Year – UWL Biology Department, Who’s Who Among Students at American Universities and Colleges, National Dean’s List ; 2001-1998, Oliver A. Stoffer Scholarship, 2000, NSF Summer Undergraduate Research Fellowship, DeLaval Inc. Scholarship:2000-1997, UW LaCrosse Dean’s List; 1999, UWL Scholarship
AFPE AWARD: Accreditation Council for Pharmacy Education - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

ROSS CORRIDEN
University of California San Diego Skaggs School of Pharmacy & Pharmaceutical Sciences
Major Pharmacology/Toxicology
GPA: 3.76/4.00
Graduation Date: July, 2007
Focus of Research: The role of P1 edenosine and P2 ATP receptors located in cell membranes in the function of human neutrophils. Insight into the functions of these receptors may lead to development of novel treatments to help prevent reperfusion-induced shock.
Title of Dissertation: “The Role of Nucleotide Release and the Activation of P1/P2 Receptors in the Modulation of Human Neutrophil Function.”
Degrees Received: B.S., Biochemistry and Molecular Biology, University of California, Santa Cruz, July 2001
Honors Received: 2005, ASPET Best Graduate Student Abstract Award, Clinical Pharmacology Division; 2001, Kenneth and Ann Thimann Scholarship, Honors in Major/College Honors; 2000, ASPET Summer Research Fellowship; 1999, Chancellor’s Undergraduate Intern; 1997, Jo Emmett and Illa Jennings Memorial Scholarship
AFPE Award: Pfizer, Inc - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

KELLY L. DAMM
University of Michigan College of Pharmacy
Major Medicinal/Pharmaceutical Chemistry
GPA: 7.89/9.00
Graduation Date: Sep-07
Focus of Research: To generate multiple protein structure (MPS) pharmacophore models based on experimentally determined structures of HIV-1 protease (HIV-1p). Resistance to current HIV-1p therapies has developed and broad spectrum inhibitors are needed that do not have the resistance liabilities of existing treatments. The use of MPS allows the sampling of a range of conformational space and the replication the inherent flexibility of a protein. By incorporating protein dynamics in our models, we expect to more accurately predict novel inhibitors of HIV-1p from chemical database screens.
Title of Dissertation: “Incorporating Protein Flexibility into Structure-Based Drug Design Using Experimentally Determined Multiple Protein Structures of HIV-1 Protease.”
Degrees Received: M.S.E., Biomedical Engineering, University of Michigan, April, 2002
B.S.E , Material Science Engineering, University of Michigan, April, 2002
Honors Received: 2004, Harold and Vivian Shapiro Award; Pharmaceutical Sciences Training Program; 2002-1997 Adolf Wurst Engineering Scholarship
AFPE Award: Novartis Pharmaceuticals - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

KERRY M. EMPEY
University of Kentucky College of Pharmacy
Major: Pharmacokinetics/Metabolism
GPA: 3.91/4.00
Graduation Date: May-06
Focus of Research: To test the hypothesis that neonatal mice treated with localized GM-CSF will be able to clear Pneumocystis infection faster secondary to a stimulation in the number and function of alveolar macrophages in order to ascertain the role of clinically relevant, pharmacologic agents (such as GM-CSF) in expediting the clearance of neonatal pulmonary infections. Alveolar macrophages appear to play a crucial role in the clearance of Pneumocystis in mice and neonatal alveolar macrophages appear to not become activated in response to Pneumocystis in contrast to adults. The current research focuses on using aerolsolized GM-CSF to expedite the clearance of Pneumocystis in neonatal mice.
Title of Dissertation: “Response of Neonatal Alveolar Macrophages to Immunostimulation and Clearance of Pneumocystis Infection.”
Degrees Received: Pharm.D, University of Rhode Island, May 1999 with High Distinction
Honors Received: 1999, Merck Scholastic Achievement Award; 1999-1994, Dean’s List, University of Rhode Island College of Pharmacy, Golden Key National Honor Society
AFPE Award: Donald & Frances Brodie – AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

PHILIP E. EMPEY
University of Kentucky College of Pharmacy
Major Pharmaceutical Sciences
GPA: 3.97/4.00
Graduation Date: Apr-06
Focus of Research: To identify potential candidate drug transport proteins that may be involved in drug accumulation in milk and to investigate the molecular mechanisms of transporter gene regulation in mammary epithelium.
Title of Dissertation: “Xenobiotic Transporter Gene Expression in Lactating Mammary Epitheilum.”
Degrees Received: Pharm.D., University of Rhode Island College of Pharmacy, May 1998
Honors Received: 2004-2002, AFPE Pre-Doctoral Fellowship, NIH Reproductive Sciences Training Grant; 2001, BCPS Certification; 2001-2000, Extra Mile Award, UK Pharmacy Residency Programs; 1998, Merck Undergraduate Research Scholar; 1998-92 Dean’s List; 1995, Phi Lambda Sigma, Rho Chi; 1993, Rho Chi High Scholastic Achievement Award
AFPE Award: Proctor & Gamble - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

JULIE A. GAASCH
Texas Tech University Health Science Center School of Pharmacy
Major Pharmaceutical Sciences
GPA: 3.82/4.00
Graduation Date: Aug-06
Focus of Research: To identify potential preventative or therapeutic measures in response to subarachnoid hemorrhage by testing the hypothesis that iron released from hemoglobin upon red cell lysis in the subarachnoid space after subarachnoid hemorrhage plays a role in mitochondrial dysfunction and cell death due to its action on calcium channels leading to excitotoxicity, apoptosis, or even necrosis.
Title of Dissertation: “The Role of Iron in Mitochondrial Dysfunction and Neuronal Cell Death in Subarachnoid Hemorrhage.”
Degrees Received: B.S., Chemistry & Biology, West Texas A&M University, May 2001
Honors Received: 2004, AFPE Pre-Doctoral Fellowship, Founding President of Graduate Student Association of Amarillo, 2001-99, President of WAMU Pre-Medicine Club; 2000, Beta Beta Beta Honor Society Academic Scholarship; 1999, Induction into Mortar Baord Honor Society; 1996, Amarillo Area Foundation Academic Scholarship
AFPE Award: National Association of Chain Drug Stores Foundation - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

GIULIA GHIBELLINI
University of North Carolina School of Pharmacy
Major Pharmaceutical Sciences
GPA: N/A
Graduation Date: May-06
Focus of Research: Establishing in-vitro and in-vivo correlations of biliary clearance of drugs in humans. Values of biliary clearance obtained in healthy volunteers will be compared to data generated in the sandwich-clutured human hepatocytes and other in-vitro models.
Title of Dissertation: “Development of In-Vitro and In-Vivo Models To Predict Hepatobiliary Clearance In Humans.”
Degrees Received: M.S., Pharmaceutical Sciences, Universita’ degli Studi di Bologna, Italy, February 1998
Honors Received: 2004, AFPE Pre-Doctoral Fellowship; 1998, Leonardo Da Vinci Grant
AFPE Award: Serono - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

SANDRA L. GOSS
University of Connecticut School of Pharmacy
Major Pharmaceutical Sciences
GPA: 3.9.0/4.00
Graduation Date: Jun-06
Focus of Research: The amount of calcium absorbed by the intestines from supplements may be limited by the precipitation of calcium carbonate due to the precipitation of bicarbonate. The potential of this physicochemical mechanism will be evaluated by in vitro and in vivo methods.
Title of Dissertation: “The Role of Gastric pH and Bicarbonate Secretion in Intestinal Absorption of Calcium from Supplements.”
Degrees Received: B.S., Pharmaceutical Science, University of Mississippi, May, 1997
Honors Received: 2004, PhRMA Pre-Doctoral Fellowship; 2002 & 2003, AFPE Pre-Doctoral Fellowship; 2003, USP Pre-Doctoral Fellowship; 1999, SmithKline Beecham Silver Award; 1997,Rho Chi Certificate of Recognition; 1997, Phi Delta Chi Academic Excellence Award; 1996, Pfizer Summer Fellowship
AFPE Award: Pfizer, Inc - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

RACHEL L. GRAVES
University of the Sciences in Philadelphia, Philadelphia College of Pharmacy
Major: Pharmaceutics
GPA: 4.0/4.00
Graduation Date: May-07
Focus of Research: The focus of my research is to use biodegradable poly(lactide-co-glycolide) blended with polyethylene glycol as scaffolds for bone regeneration applications. Different formulations will be investigated to determine the effects of fabrication method on thermal, mechanical, and degradation properties of the scaffolds. The scaffolds will also be investigated for immunogenicity, cell attachment, and cell differentiation in vitro and in vivo.
Title of Dissertation: “Biodegradable-PEG Eluting Scaffolds for Bone Regeneration.”
Degrees Received: B.S., Chemical Engineering, Bucknell University, May 2002
Honors Received: 2004, Rho Chi; 2002-1998, Dean’s List, Bucknell University; 1998,Alpha Lambda Delta Honors Society
AFPE Award: Wyeth - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

XINYI GU
University of Michigan College of Pharmacy
Major Pharmaceutical Sciences
GPA: 8.2/9.0
Graduation Date: Sep-07
Focus of Research: To enhance the targeting specificity of chemotherapeutic agents using a two component system composed of 1) polymeric stealth nanoparticle encapsulating the drug and 2) targeting antibody chemically linked to poly(ethylene) glycol) (PEG) strands protruding from the surface of the nanoparticles.
Title of Dissertation: “Enhanced Targeting of Chemotherapeutic Agents for the Treatment of Cancer.”
Degrees Received: B.S., Biochemistry, University of Illinois-Urbana Champaign, May 2002
AFPE Award: Johnson & Johnson Pharmaceutical Research & Development - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

JASON M. HELD
University of California at San Francisco School of Pharmacy
Major Pharmaceutical Sciences
GPA: 3.84/4.0
Graduation Date: Nov-05
Focus of Research: To determine the nature of dauer-specific DAF-12 PTMs, to identify DAF-12 interacting proteins including co-repressors, co-activators, and hetero-dimerization partners, and to identify the endogenous DAF-12 ligand. DAF-12 as a nuclear receptor that is a major determinant of the complex phenotypes of dauer formation, adult stress resistance, and lifespan in the nematode C. elegans based on genetic studies. DAF-12 integrates a series of environmental conditions and signaling pathways to alter the worm life history. Mass spectrometric methods will be used to investigate the dauer-specific alterations in DAF-12 to gain insight into how nuclear receptors are able to modulate such a complex phenotype.
Title of Dissertation: “DAF-12’s Role in the Molecular Mechanism of C. Elegans Dauer Regulations.”
Degrees Received: B.S. Biology, Duke University, May 2001
Honors Received: 2004, AAPS membership, American Society of Mass Spectrometry, San Francisco Bay Mass Spectrometry Group; 2001, Achievement Rewards for College Scientists Foundation Scholar; 2000, Howard Hughes Undergraduate Neuroscience Fellow; 1999, Undergraduate Research Grant Recipient from Duke University; 1997, American Chemical Society Award for Excellence in Chemistry
AFPE Award: American Association of Pharmaceutical Scientists - AFPE Fellowship in Pharmaceutical Science

ELIZABETH J. HOHNADEL
University of Georgia College of Pharmacy
Major Pharmacology/Toxicology
GPA: 3.64/4.0
Graduation Date: May-06
Focus of Research: To determine the safest and most effective neuroleptic for young papient populations. Current neuroleptic treatment of psychiatric disorders (e.g. autism, schizophrenia) in children and adolescents may have adverse effects on cognitive and physiological development.
Title of Dissertation: “Evaluation of Atypical Versus Typical Antipsychotic Strategies in a Neurodevelopmental Rat Model of Schizophrenia.”
Degrees Received: M.S., Biology, Georgia College & State University, August 2002
M. Ed., Outdoor Education, Georgia College & State University, May 1998
B.S., Biology, Presbyterian College, May 1992
Honors Received: 2004 AFPE Pre-Doctoral Fellowship, Society for Neuroscience Membership
AFPE Award: AFPE 21st Century Club Pre-Doctoral Fellowship in Pharmaceutical Science

BRYAN H. HUYNH
University of Kansas School of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 3.71/4.00
Focus of Research: The development of a miniaturized analysis system coupled to on-line microdialysis sampling. The intended micro total analysis (uTAS) will incorporate the following on a single planar device: 1) sample delivery, 2) derivatization, 3) injection, 4) separation, and 5) detection. Such a system can be used for high temporal monitoring applications, i.e. bioreactors of pharmaceutical products.
Graduation Date: Feb-06
Title of Dissertation: “Development of a Microchip Capillary Electrophoresis System with On-line Microdialysis Sampling for High-Temporal Monitoring Applications.”
Degrees Received: M.S., Pharmaceutical Chemistry, University of Kansas; January 2003
B.S., Chemistry, Truman State University, December 1999
Honors Received: 2005, KU Pharmacy School Graduate Honors Speaker; 2005-2002, NIH Biotechnology Training Grant; 2004, AAPS Graduate Student Award, APQ section, Pfizer Summer Internship Poster Award; 1999, Dr. Victor Kaylarian Undergraduate Research Award, Dr. Dale Fox Undergraduate Research Scholarship
AFPE AWARD: Josiah Kirby Lilly Sr Memorial - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

CORY S. KENDING
University of Minnesota College of Pharmacy
Major Medicinal/Pharmaceutical Chemistry
GPA: 3.76/4.0
Graduation Date: Sep-07
Focus of Research: To optimize a 5.5.5 spirobicyclic type II b-turn mimic, which have dopamine receptor modulating activity, by placing sidechains upon the scaffold. The hypothesis is the hydrophobic sidechains will increase the compound’s potency by interacting with the same hydrophobic pocket as the native peptide. The substitutions in this series are designed to mimic the critical sidechain interactions between PLG and its receptor.
Title of Dissertation: “Synthesis of b-substituted 5.5.5 Spiro Bicyclic Type II b-turn Mimic Analogues”
Degrees Received: B.A., Biochemistry, Knox College, June 1998
Honors Received: 2004, AFPE Pre-Doctoral Fellowship; 1998, Knox College Biochemistry Award, Mortar Board; 1998-94, Dean’s List, Howard Johnson Scholar
AFPE Award: USP-AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

BRIAN R. KEPPLER
University of North Carolina School of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: N/A
Graduation Date: May-06
Focus of Research: Performing cancer-based research involving enzyme telomerase, which is the ribonucleicprotein complex that extends telomeric DNA. Investigating small molecule interactions with the RNA subunit of telomerase. The research hypothesis is that appropriately designed human telomerase RNA-binding ligands will affect telomerase assemblage and perturb enzymatic activity. The goal of the research project is to provide a novel approach to control cellular immortality and provide a new anticancer drug modality.
Title of Dissertation: "Targeting Human Telomerase Holoenzyme Assemblage”
Degrees Received: B.S., Chemistry, Emory University, May 2000
Honors Received: 2004, Impact Award, Alpha Epsilon Lambda Honor Society; 2003, Rho Chi; 1997, Phi Eta Sigma Honor Society
AFPE Award: USP-AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

HILLIARD KUTSCHER
Rutgers University Ernest Mario School of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.8/4.00
Graduation Date: Dec-07
Focus of Research: To gain molecular insights into transporter-based AIDS drug level interactions and develop a predictive absorption-disposition mathematical model by measuring HIV drug levels in blood and tissue using in-situ rat intestinal perfusion and in-vivo methods. The data obtained will be used to improve a previously developed first generation mathematical model. Published human pharmacokinetic studies related to HIV drugs will also be examined, exploring correlations between the preclinical data. The main focus of the projects is drug interactions between two therapeutic agents and multiple drug transporters in the blood and possibly the brain. A model based on more than two agents may be looked at if promising results are published in the HIV clinical literature.
Title of Dissertation: “Molecular and Mathematical Insights into Transporter-based AIDS Drug Level Boosting.”
Degrees Received: B.S., Chemical Engineering, Clarkson University, May 2001
Honors Received: 2005, AFPE Pre-Doctoral Fellowship, Rho Chi; 2001-1997, Clarkson University’s Presidential Scholarship; Clarkson University’s Dean List; 1999-1997, Clarkson University Presidential Scholar
AFPE Award: Josiah Kirby Lilly, Sr. Memorial - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

P. THERESE LANG
University of California San Francisco School of Pharmacy
Major Medicinal/Pharmaceutical Chemistry
GPA: 3.82/4.0
Graduation Date: Jun-06
Focus of Research: To optimize the DOCK suite of programs for RNA targets and develop a new scheme for docking small molecules to RNA. These techniques will be applied to designing a novel inhibitor for the HIV1 target, TAR RNA.
Title of Dissertation: “Development and Optimization of Theoretical Techniques for Screening Libraries Against RNA Targets.”
Degrees Received: B.A., Chemistry/Biochemistry, La Salle University, May 2001
Honors Received: 2005-2004 AFPE Pre-Doctoral Fellowship, 2004-2002, Burroughs Wellcome Fellowship; 2002- 2001, Burroughs Wellcome Traineeship; 2001, Graduate Dean Fellow in Health Science, NSF Fellowship--Honorary Mention, La Salle Chemistry Best of Class; Magna Cum Laude
AFPE Award: GlaxoSmithKline - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

YVONNE Y. LAU
University of California San Francisco School of Pharmacy
Major Pharmacokinetics/Metabolism
GPA: 3.93/4.0
Graduation Date: Jun-06
Focus of Research: Focus is on hepatic transporters and how they may control the access of drug molecules to metabolizing enzymes: changes in transporter function can change hepatic metabolism without apparent affecting enzyme activity.
Title of Dissertation: “Examining the Regulation of Hepatic Drug Disposition, Metabolism by Organic Anion Transporting Polypeptide (OATP-C) and P-glycoprotein (P-gp) and Multi-Drug Associated Protein (MRP2)”
Degrees Received: B.S. Biomedical Engineering, Johns Hopkins University, May 2001
Honors Received: 2005, International Society for the Study of Xenobiotics, 2004-2003, AFPE Pre-Doctoral Fellow; 2002, American Association of Pharmaceutical Scientists; 2001, Tau Beta Pi, National Engineering Honor Society; 2000, Provost’s Undergraduate Research Awards, 2000-1997, Dean’s List, 1999, Alpha Eta Mu Beta, National Biomedical, Engineering Honor Society
AFPE Award: Novo-Nordisk - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

HEATHER M. LEITNER
University of Colorado at Denver and Health Sciences Center School of Pharmacy
Major Pharmacology/Toxicology
GPA: 3.79/4.0
Graduation Date: Dec-07
Focus of Research: Developing a fuller understanding of the mechanistic basis for the initiation and progression of severe toxicity related to highly active antiretroviral therapy (HAART), with a special emphasis on nucleotide reverse transcriptase inhibitors. The goal is understanding how the mechanisms for development of toxicity to HAART agents relates to relevant genetic polymorphisms within the human population
Title of Dissertation: “Mitochondrial Toxicity and Highly Active Antiretrovial Therapy (HAART).”
Degrees Received: M.S., Environmental Science and Engineering, Colorado School of Mines, August, 2002
B.S., EMS and Biology, Creighton University, August, 2000
Honors Received: 2004, Society of Toxicology; 1999-1995, Reinert Scholarship; 1998-1996, Westminster Fire and Rescue Scholarship; 1995, ASA Education Scholarship, Westminster Elks Outstanding Student Award, Dean Honor List
AFPE Award: IVAX Pharmaceuticals - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

THONG C. MA
The Ohio State University College of Pharmacy
Major Pharmacology/Toxicology
GPA: 3.84/4.0
Graduation Date: Jun-06
Focus of Research: The neurotoxicity of free 3-nitrotyrosine (free-3NT) and its role in Parkinson’s disease (PD) pathogenesis. Free-3NT is produced endogenously by oxidative chemistries, is elevated in Parkinson’s Disease, and causes PD-like neuron loss when injected into mouse brains. Determining the molecular mechanisms of this toxicity will increase understanding of the disease and possibly identify therapeutic targets
Title of Dissertation: “The Molecular Mechanisms of Free 3-nitrotyrosine Neurotoxicity.”
Degrees Received: B.S., Pharmacy, Ohio State University, December 2001, Summa Cum Laude
Honors Received: 2002, Marvin & Geraldine Faegles Memorial Award
AFPE Award: Sankyo Pharma - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

JOANNA L. MICHEL
University of Illinois at Chicago College of Pharmacy
Major Pharmacognosy
GPA: 4.87/4.0
Graduation Date: May-06
Focus of Research: A multi-disciplinary study of the biological activity of medicinal plants used by the Q’eqchi Maya of Quatamala for women’s health, with a particular focus on menopause.
Title of Dissertation: “ Q’eqchi Mayan Medicine for Women’s Health”
Degrees Received: Certification, Ecological Horticulture, University of California- Santa Cruz, October 1998
B.A., Spanish & Premedical Sciences, Tulane University, June 1994
Honors Received: 2004, AFPE Pre-Doctoral Fellowship; 2003, US Fulbright Scholarship, Myron Goldsmith Scholarship UIC, Charles Bondy Memorial Scholarship; 2002, AFPE Pre-Doctoral Fellowship; 1994, Premio Clavileno Excellence in Latin American Literature Studies; 1994-1990, Tulane University Academic Achievement and Need-based Tuition Scholarship
AFPE Award: National Association of Boards of Pharmacy - Doctoral Fellowship in Pharmaceutical Science

MATTIA M. MIGLIORE
Northeastern University Bouve College of Health Sciences School of Pharmacy
Major: Pharmacology/Toxicology
GPA: 3.664
Graduation Date: Jun-07
Focus of Research: Designing an improved drug delivery system to facilitate the transport of a brain impermeable protein, Glial Derived Neurotrophic Factor (GDNF), across the blood brain barrier. GDNF, once across the blood brain barrier, has been shown to protect dopamine cells from being destroyed. Dopamine neurons are destroyed in Parkinson’s disease, and GDNF has the potential to become a valuable treatment for Parkinson’s disease.
Title of Dissertation: “Improving Brain Penetration of GDNF Utilizing Novel Drug Delivery Systems: An Alternative Treatment for Parkinson’s Disease”
Degrees Received: M.S., Pharmacology, Northeastern University, December 2002
B.S., Pharmacy, Massachusetts College of Pharmacy, May 1997
Honors Received: 1996, Rho Chi National Honor Society, Pharmacy Student of the year @ Boston Regional Medical Center
AFPE Award: Josiah Kirby Lilly, Sr. Memorial - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

DAVE A. MILLER
University of Texas at Austin College of Pharmacy
Major: Pharmaceutics
GPA: 4.0/4.0
Graduation Date: May-07
Focus of Research: Improving the wetting and dissolution of Biopharmaceutical Classification System Class (BSC) II drugs using a novel delivery system produced via fine particle engineering technologies and hot-melt extrusion.
Title of Dissertation: “Investigation of Physiochemical Properties of Solid Dispersions of Fine Drug Particles in a Stabilizing Polymeric Carrier for Use in Drug Delivery Applications.”
Degrees Received: B.S. Chemical Engineering, University of Texas at Austin, December 2002
Honors Received: 2004, Rho Chi Pharmacy Honor Society; 2002-2001, Chemical Engineering Departmental Scholarship, Honors Day Collegiate Scholar Award; 2000, National Society of Collegiate Scholars
AFPE Award: AstraZeneca - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

KIRK A. OVERHOFF
University of Texas at Austin College of Pharmacy
Major Pharmaceutics
GPA: 3.93/4.0
Graduation Date: May-06
Focus of Research: To increase the wetting and dissolution rate of poorly water-soluble drugs using novel particle engineering processes that can ultimately lead to increased bioavaibility of the drug.
Title of Dissertation: “Improvement of Active Bioavailability Using Ultra-Rapid Freezing.”
Degrees Received: B.S., Chemical Engineer, University of Texas at Austin, December 2001
Honors Received: 2004, AFPE Pre-Doctoral Fellowship, Rho Chi Pharmacy Honor Society
AFPE Award: Johnson & Johnson Pharmaceutical Research & Development - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

MARK E. PATTERSON
University of North Carolina School of Pharmacy
Major Pharmaceutical Sciences
GPA: 3.82/4.00
Graduation Date: May-06
Focus of Research: Examining whether copayment increases for ACE inhibitors, beta blockers, and diuretics result in decreased medication adherence and increased hospitalizations in commercially insured heart failure patients.
Title of Dissertation: “Effect of Copayments on Medication Persistence in a Commercially Insured Population with Heart Failure.”
Degrees Received: A.B., Neuroscience, Bowdoin College, May 1997
M.P.H., Chronic Disease Epidemiology,Yale University School of Public Health, May 2002
Honors Received: 2003– 2002, UNC Scholars for Tommorrow Fellow; 2001, GAO Exceptional Summer Student Award; 1997, magna cum laude, Bowdoin College, Neuroscience Departmental Honors, Bowdoin; 1996, NIH Exceptional Summer Student Award
AFPE Award: American Association of Pharmaceutical Scientists - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

BRIANNA L. PETERSON
University of Georgia College of Pharmacy
Major Pharmacology/Toxicology
GPA: 4.0/4.0
Graduation Date: May-07
Focus of Research: Determine the role calcium-independent phospholipase A2 plays in neuronal cell death induced by drugs of abuse. .
Title of Dissertation: “Calcium-Independent Phospholipase A2 Mediates Neuronal Cell Death During Oxidative Stress Induced by Drugs of Abuse.”
Degrees Received: M.S., Forensic Science, University of Illinois at Chicago, August 1999
B.S., Chemistry, University of Wisconsin- La Crosse, May 1997
Honors Received: 2005,Society of Toxicology In Vitro Section Award; 2003, University of Georgia University Wide Graduate Fellowship Scholarship; 1997, Allen Chemistry Graduate Incentive; 1996,Golden Key National Honor Society
AFPE Award: Janssen - AFPE Pre-Doctoral Fellowship in Pharmaceutical Science

CECILIA M. PLAZA
University of Arizona School of Pharmacy
Major: Social & Administrative Science
GPA: 3.92/4.0
Graduation