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2006-07 AFPE Gateway Research Scholarship Winners

ELIZABETH A. FANG
Northeastern University School of Pharmacy
Faculty Sponsor: Robert Campbell, Ph.D.
Faculty Sponsor Title: Assistant Professor, Pharmaceutics/Pharmacy
Major: Pharm.D.
GPA: 3.99/4.00
Expected Graduation: May 2008
Focus of Research: To evaluate doxorubicin hydrochloride and its ability to inhibit the growth of two human colorectal cancer cell lines, CCL-222 and CCL-247, and to develop and characterize a novel doxorubicin hydrochloride suppository dosage form to be used for colorectal cancer treatment.
Title of Research: “Development and Characterization of a Novel Suppository Dosage Form Against Human Colorectal Carcinoma.”
Degrees Received: N/A
Honors Received: 2006, AFPE Gateway to Research Scholarship; 2006-05, Northeastern University President’s Award for Outstanding Scholarship; 2006-02, Carl S. Ell Scholar; 2005, Phi Kappa Phi Award for Scholastic Achievement, Tylenol Scholar; 2002, Eagle Foundation Salutatorian Award, Hampden Republican Association Scholarship, Fitz Randolph Scholar/Academic Order of Merit; 2001, Pennsylvania Governor’s School for Health Care
AFPE Award: Frederick W. Telling Endowed AFPE Gateway To Research Scholarship

TIFFANY J. GILLIES
South Dakota State University College of Pharmacy

Faculty Sponsor: Gareth Davies, Ph.D.
Faculty Sponsor Title: Assistant Professor, Pharmaceutical Sciences
Major: Pharm.D.
GPA: 3.98/4.00
Expected Graduation: May 2009
Focus of Research: To elucidate the regulatory role of specific transcription factors in human adipocytes with the long-term goal of determining their significance in HIV-1 positive patients and the pathogenesis. Lipidistrophy is a very serious complication associated with HIV-1 positive patients resulting in body morphology changes, cardiovascular disease and diabetes. Little is known regarding the pathogenesis of this disorder but it is believed to be due to defects in the pre-adipocyte differentiation process
Title of Research: “Molecular Pathogenesis of HIV Associated Lipidistrophy.”
Degrees Received: B.S., Psychology, Lake Superior State University, May 2004
Honors Received: 2006, AFPE Gateway to Research Scholarship; 2005, Dean’s List – SDSU; 2005-00, Dean’s List – LSSU; 2004, LSSU Student Respondent, LSSU Female Senior of the Year; 2003, Judge James Fenlon Award, ASAP Outstanding Student Leader, Alpha Chi National Honor Society; 2003-02, ASAP D5 Outstanding Student Leader; 2002, LSSU Female Sophomore of the Year; 2001, LSSU Female Freshman of the Year
AFPE Award: GlaxoSmithKline - AFPE Gateway To Research Scholarship

SAMREEN KHATRI
Butler University College of Pharmacy and Health Sciences
Faculty Sponsor: Sudip Das, Ph.D.
Faculty Sponsor Title: Associate Professor and Department Chair, Pharmaceutical Sciences
Major: Pharm.D.
GPA: 3.93/4.00
Expected Graduation: May 2008
Focus of Research: To develop polyamidoamine (PAMAM) dendrimer – methotrexate conjugates and study their in-vitro physicochemical properties and cellular uptake.
Title of Research: “Cellular Uptake of Methotrexate Encapsulated in Dendritic Nanodevices.”
Degrees Received: N/A
Honors Received: 2006, AFPE Gateway to Research Scholarship, Rho Chi Membership; 2005, Pfizer Summer Undergraduate Research Fellowship, The Honor Society of Phi Kappa Phi; 2005-02, Dean’s List; 2004, Blue Key Honor Fraternity; 2003, Alpha Lambda Delta Freshman Honor Society, Award for Excellence in General Chemistry
AFPE Award: Johnson & Johnson Pharmaceutical Research & Development – AFPE Gateway to Research Scholarship

GOWRI K. MURTHY
Creighton University School of Pharmacy and Health Professions
Faculty Sponsor: Alekha Dash, Ph.D.
Faculty Sponsor Title: Professor and Interim Chair, Pharmaceutics/Pharmacy
Major: Pharm.D.
GPA: 3.40/4.00
Expected Graduation: May 2008
Focus of Research: To prepare and characterize paclitaxel in situ gel delivery system for targeted delivery to cancerous cells in order to learn more about the cellular uptake of paclitaxel from this gel delivery system in two in vitro cell culture models (MDA-231 and MDA-453).
Title of Research: “A Novel Mucoadhesive Gel Delivery System for the Treatment of Breast Cancer.”
Degrees Received: B.S., Microbiology, University of Michigan, April 2003
Honors Received: 2006, AFPE Gateway to Research Scholarship; 2004, Creighton University Dean’s List
AFPE Award: AstraZeneca Pharmaceuticals - AFPE Gateway To Research Scholarship

VIET V. NGUYEN
University of California at San Francisco School of Pharmacy
Faculty Sponsor: Deanna L. Kroetz, Ph.D.
Faculty Sponsor Title: Associate Professor and Vice Chair, Biopharmaceutical Sciences
Major: Pharm.D.
GPA: 3.21/4.00
Expected Graduation: June 2007
Focus of Research: To determine the relationship between the expression of multidrug resistance transporters and medically refractory epilepsy. Specifically, the research will assess whether multidrug resistance in epilepsy is related to differential expression of one or more of the ABC transporter proteins within epileptic foci. The focus of these studies will be on P-glycoprotein, multidrug resistance associated proteins 1 and 2 (MRP1 and MRP2), and mitoxantrone resistance protein (MXR). Drug resistance due to target selectivity will also be addressed.
Title of Research: “Multidrug Resistance Transporters and Anticonvulsant Resistance.”
Degrees Received: M.S., Cell and Neurobiology, University of Southern California, May 2004
B.A., Biological Sciences, University of Southern California, December 2001
B.A., Classics, University of Southern California, December 2001
Honors Received: 2006, AFPE Gateway to Research Scholarship; 2001, USC Alumni Association Scholarship; 2001-97, USC Deans Scholarship, USC Thematic Options Honors; 2000, USC APASA Woman of the Year Scholarship
AFPE Award: Pfizer Inc. - AFPE Gateway To Research Scholarship

NICOLE R. PINELLI
Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences
Faculty Sponsor: James S. Kalus, Pharm.D., BCPS
Faculty Sponsor Title: Assistant Professor, Pharmacy Practice
Major: Pharm.D.
GPA: 3.55/4.00
Expected Graduation: May 2007
Focus of Research: To understand the influence of the pharmacodynamic effects of the renin-angiotensin-aldosterone (RAA) system inhibitors on the pathophysiologic processes occurring in atrial fibrillation. Specifically, the research will evaluate the effect of RAA system inhibitors on physiologic markers of stroke risk and cardiac remodeling in patients with atrial fibrillation and will also evaluate the value of dual RAA system inhibitors in patients with atrial fibrillation.
Title of Research: “Neurohormonal Inhibition of Atrial Fibrillation.”
Degrees Received: N/A
Honors Received: 2006, AFPE Gateway to Research Scholarship, Michigan College of Pharmacy Scholarship Award, Michigan Pharmacists Association Patient Counseling Competition-Top 10 Finalist; 2004-00, Wayne State University Presidential Scholarship-128 Credits of Full Tuition and Fees; 2003, Gamma Sigma Alpha Honor Society-Chartering Member at WSU & Current President, National Dean’s List; 2003-01, Alpha Gamma Delta Scholarship Award; 2003-00, Wayne State University Honors Program; 2001, Wayne State University Top 10% of Chemistry Students Award
AFPE Award: Pfizer Inc. - AFPE Gateway To Research Scholarship

MIHAELA POPESCU
University of Illinois at Chicago College of Pharmacy
Faculty Sponsor: Hayat Onyuksel, Ph.D.
Faculty Sponsor Title: Professor and Associate Head, Biopharmaceutical Sciences
Major: Pharm.D.
GPA: 3.36/4.00
Expected Graduation: May 2009
Focus of Research: To study the delivery of insoluble drugs and peptides using phospholipids nanocarriers for the treatment of breast cancer, rheumatoid arthritis and Alzheimer’s disease.
Title of Research: “Potential Novel Nanomedicine for Alzheimer’s Disease.”
Degrees Received: Associate Degree, Pre-pharmacy, University of Illinois at Chicago, June 2005
Honors Received: 2006, AFPE Gateway to Research Scholarship, Osco Drug Scholarship
AFPE Award: American Association of Pharmaceutical Scientists - AFPE Gateway To Research Scholarship

JUSTIN A. PRESTRIDGE
University of Louisiana-Monroe College of Pharmacy
Faculty Sponsor: Khalid El Sayed, Ph.D.
Faculty Sponsor Title: Assistant Professor, Medicinal/Pharmaceutical, Chemistry/Pharmacognosy
Major: Pharm.D.
GPA: 3.44/4.00
Expected Graduation: May 2008
Focus of Research: To isolate adequate amounts of the cembranoid 2, 7, 11-cembratriene- 4, 6- diol which has documented anticancer activity from fresh raw tobacco and to execute biocatalytic and semi-synthetic modifications in an attempt to enhance the previously documented anticancer activity. The antiangiogenic activity will be tested with chick embryo assays in our lab, while antiproliferative activity will be evaluated in our sister lab.
Title of Research: “Biocatalytic and Semisynthetic Studies of the Anticancer Tobacco Cembranoid 2, 7, 11-Cembratriene- 4, 6- Diol.”
Degrees Received: N/A
Honors Received: 2006, AFPE Gateway to Research Scholarship; 2003, CRC Press Freshman Chemistry Achievement Award
AFPE Award: Novartis Pharmaceuticals - AFPE Gateway To Research Scholarship

DANIEL P. ROMARY
Purdue University School of Pharmacy and Pharmaceutical Sciences
Faculty Sponsor: Lynne S. Taylor, Ph.D.
Faculty Sponsor Title: Assistant Professor, Industrial and Physical Pharmacy
Major: Pharm.D., BS Pharmaceutical Sciences
GPA: 3.79/4.00
Expected Graduation: May 2009
Focus of Research: To identify the physicochemical properties of crystalline active pharmaceutical ingredients (APIs) and the polymer that may lead to such a transformation and identify the mechanism of transformation. Many pharmaceutical polymers are very hygroscopic and can absorb large quantities of moisture from the atmosphere. We have observed that at high relative humidity, crystalline active pharmaceutical ingredients (APIs) dispersed in a polymeric matrix may undergo a spontaneous phase transformation leading to a loss of crystallinity.
Title of Research: “Spontaneous Crystallinity Loss of Drugs in Polymer Matrices in the Presence of Water.”
Degrees Received: N/A
Honors Received: 2006, AFPE Gateway to Research Scholarship, Charles V. and Madonna Flemming Scholarship, Angelo and Jeannine Carnaghi Scholarship; 2005, Beta Sigma Psi Dr Jerome W Blank Award, Beta Sigma Psi Academic Success Award, Dean’s Undergraduate Research Fellowship, Helen Carney Trust Scholarship; 2005-03, Dean’s List; 2004, School of Pharmacy Excellence 4.0 GPA; 2003, Purdue Academic Success Award
AFPE Award: American Association of Pharmaceutical Scientists - AFPE Gateway To Research Scholarship

BARBARA L. ROPER
University of Utah College of Pharmacy
Faculty Sponsor: Diana Brixner, Ph.D., RPh
Faculty Sponsor Title: Associate Professor and Chair, Department of Pharmacotherapy
Executive Director, Pharmacotherapy Outcomes Research Center
Major: Pharm.D.
GPA: 3.39/4.00
Expected Graduation: May 2009
Focus of Research: To complete a single-institution, retrospective, cohort study comparing patient characteristics, patterns of care, incidence and costs of hospitalizations for Neutropenia Related Complications (NRC) among patients who received myelosuppressive chemotherapy in 2003-2005.
Title of Research: “Characterization of Growth Factor Use in a University Hospital Setting.”
Degrees Received: A.S., Chemistry, Salt Lake Community College, May 2004
A.S., General Studies, Salt Lake Community College, May 2004
B.A., Economics, University of Utah, December 1989
Honors Received: 2006, AFPE Gateway to Research Scholarship; 2003, Phi Theta Kappa Honor Society, Organic Chemistry Student of the Year, American Chemistry Society Student Affiliate; 2002, General Chemistry Student of the Year, American Chemical Society Student Affiliate; 1983, Outstanding Service, Lambda Delta Sigma
AFPE Award: American Society of Health-System Pharmacists - AFPE Gateway To Research Scholarship

JASON E. SCOTT
Southern Illinois University Edwardsville School of Pharmacy
Faculty Sponsor: Ronald Worthington, Ph.D.
Faculty Sponsor Title: Assistant Professor, Biological Sciences
Major: Pharm.D.
GPA: 3.52/4.00
Expected Graduation: May 2009
Focus of Research: To analyze genetic variation in relation to drug responses with a focus on variations in patients resistant to clopidogrel.
Title of Research: “Pharmacogenetic Analysis of Drug Target Polymorphisms in Patients Resistant to Clopidogrel.”
Degrees Received: B.A., Biology, Blackburn College, May 2005
B.A., Chemistry, Blackburn College, May 2005
Honors Received: 2006, AFPE Gateway to Research Scholarship; 2005, Chemistry Department Award, Student worker Award; 2004 Alpha Chi; 2000, Presidential Scholarship - Blackburn College; 1999-98, Scholar Athlete; 1998, Math Award; 1997, 4-H Humanitarian Award
AFPE Award: ASHP Foundation - AFPE Gateway To Research Scholarship

CARISA N. SHAW
Campbell University School of Pharmacy
Faculty Sponsor: Thomas Abraham, Ph.D.
Faculty Sponsor Title: Assistant Professor, Pharmacology/Toxicology
Major: Pharm.D.
GPA: 3.40/4.00
Expected Graduation: May 2009
Focus of Research: To investigate the expression of CaMKII in mediating VSM cell migration in plaque regions from aorta of ApoE knockout mice.
Title of Research: “CaMKII Expression in Atherosclerotic Plaques.”
Degrees Received: B.S., Biology, Campbell University, May 2001
Honors Received: 2006 AFPE Gateway to Research Scholarship
AFPE Award: Ortho-McNeil Janssen Scientific Affairs - AFPE Gateway To Research Fellowship

MARY J. STUNSON
Southern Illinois University Edwardsville School of Pharmacy
Faculty Sponsor: Guim Kwon, Ph.D.
Faculty Sponsor Title: Assistant Professor, Pharmacology/Toxicology
Major: Pharm.D.
GPA: 4.00/4.00
Expected Graduation: May 2009
Focus of Research: To study the role of Adipocyte differentiation-related protein (ADRP) in the B-cell lipotoxicity by knocking out the ADRP gene using small interfering RNA (siRNA). Adipocyte differentiation-related protein (ADRP) is a predominant lipid vesicle associated protein found in the B-cell. ADRP is hypothesized to provide a protective mechanism from the B-cell lipotoxicity by containing lipid molecules within the lipid vesicles.
Title of Research: “Role of ADRP in the Beta-Cell Lipotoxicity Associated with Obesity Mediated Type 2 Diabetes.”
Degrees Received: N/A
Honors Received: 2006, AFPE Gateway to Research Scholarship; 2006-05, SIUE Dean’s List; 2004, National Society of Collegiate Scholars; 2003, University of Evansville’s Honors Program
AFPE Award: American Association of Pharmaceutical Scientists - AFPE Gateway To Research Scholarship

CHRISTOPHER D. TURPIN
University of Oklahoma College of Pharmacy
Faculty Sponsor: Randle M. Gallucci, Ph.D.
Faculty Sponsor Title: Assistant Professor, Pharmaceutical Sciences
Major: Pharm.D.
GPA: 3.30/4.00
Expected Graduation: June 2007
Focus of Research: To evaluate the role of IL-6 in diabetic pathogenesis in the skin and liver by testing the hypothesis that IL-6R function may be altered by hyperglycemic environments, thus leading to pathology associated with improper IL-6 signal transduction.
Title of Research:

“The Effects of Hyperglycemia on IL-6R Signaling and Gene Expression.”

Degrees Received: Associate Degree, Pre-Pharmacy, Oklahoma City Community College, May 2003
Honors Received: 2006 AFPE Gateway to Research Scholarship
AFPE Award: United States Pharmacopeia (USP) – AFPE Gateway To Research Scholarship

SIDNEY A. VEACH
University of Arkansas for Medical Sciences College of Pharmacy
Faculty Sponsor: Amy M. Franks, Pharm.D.
Faculty Sponsor Title: Assistant Professor, Pharmacy Practice
Major: Pharm.D.
GPA: 4.00/4.00
Expected Graduation: May 2008
Focus of Research: To directly evaluate the potentially antiatherogenic effects of rosiglitazone and pioglitazone in type 2 diabetes patients by administrating either rosiglitazone or pioglitazone daily to up to 30 type-2 diabetes patients for 3 months. The study will seek to determine if treatment with rosiglitazone or pioglitazone affects platelet function as assessed by spontaneous and agonist-induced platelet aggregation. In addition, the study will seek to determine if selected hemostatic parameters and adipocytokines (fibrinogen, PAI-1, CRP, adiponectin, and leptin) are altered in response to treatment with rosiglitazone or pioglitazone.
Title of Research: “Effects of Short-Term Thiazolidinedione Treatment on Vascular Risk Makers in Type-2 Diabetes Patients.”
Degrees Received: B.A., Biology, Hendrix College, May 2004
Honors Received: 2006, AFPE Gateway to Research Scholarship, Pharmacy Practice Research Fellowship; 2005, Pharmacy Practice Research Fellowship
AFPE Award: Wyeth- AFPE Gateway To Research Scholarship

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