DAVID
G. ANDERSON |
University
of Iowa College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA: |
4.0/4.0 |
| Graduation
Date: |
August 2010 |
| Focus
of Research: |
To characterize
and synthesize oxidative metabolites of dopamine potentially involved
in Parkinson’s disease (PD). Dopamine and certain dopamine
metabolites, such as the deaminated aldehyde 3,4- dihydroxyphenylacetaldehyde
(DOPAL), are known to be neurotoxic and believed to play a role
in disease pathogenesis. The research includes establishing conditions
suitable for synthesis of the quinine derivatives of DOPAL, characterizing
the reactivity of this compound toward relevant cellular and protein
nucleophiles, as well as structural determination of any resultant
adduct products. The information established by these projects
will allow the determination of the presence and/or importance
of DOPAL quinone in PD. |
| Title
of Dissertation: |
“Protein
Modification by Oxidized Derivatives of Dopamine and Dopamine
Metabolites in Regards to Parkinson’s Disease and Neurodegenerative
Disorders.” |
| Degrees
Received: |
B.S., Chemistry,
Exercise Science, Elmhurst College, June 2005 |
| Honors
Received: |
2005, Medicinal
and Natural Products Division Fellow, Rudolf J. Priepke Scholastic
Achievement Award in Chemistry, Elmhurst College Ranking Scholar;
2005-2000, Elmhurst College Presidential Scholarship, Dean’s
List; 2004, Lloyd J. Palmer Nalco Chemical Co. Endowed Scholarship |
| AFPE
Award: |
Ernest Mario
Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
CHARLENE A. BAKSH |
University
of Maryland at Baltimore School of Pharmacy |
| Major
|
Pharmacokinetics/Metabolism |
| GPA:
|
3.89/4.00 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To develop
a model which will be able to predict UCN-01 (7-Hydroxystaurosporine)
concentrations using a1-Acid Glycoprotein (AAG) levels, along
with other common covariates. |
| Title
of Dissertation: |
“Development
of a Pharmacokinetic Model to Predict 7- Hydroxystaurosporine
(UCN-01) Concentrations Using a1-Acid Glycoprotein to Optimize
Treatment Regimens and Minimize Toxicity.” |
| Degrees
Received: |
Pharm.D.,
University of Maryland at Baltimore, May 2004 |
| Honors
Received: |
2006, AFPE
Pre-Doctoral Fellowship; 1999, Outstanding Academic Achievement
as a Sophomore |
| AFPE
Award: |
21st Century
Club - Albert B. Fisher, Jr. Memorial - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
KATHERINE M. BLOCK |
University
of Arizona College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
4.0/4.0 |
| Graduation
Date: |
May 2009 |
| Focus
of Research: |
To design
and test a new class of anti-angiogenic compounds, epidithiodiketopiperazines
(ETPs), intended to block tumor-driven hypoxia signaling with
small molecules designed to inhibit key protein-protein interactions
occurring in the nucleus. Tumor cells are frequently deficient
in oxygen, a condition known as hypoxia. This hypoxia initiates
a signaling cascade through HIF-1a (hypoxia inducible factor),
a protein that induces the expression of a variety of genes involved
in angiogenesis. The research will determine the efficacy and
elucidate the mechanisms of action of a class of compounds designed
as transcriptional inhibitors of HIF-1a. The goal is to provide
new therapeutic agents offering significantly improved safety
profiles. |
| Title
of Dissertation: |
“Small
Molecule Inhibitors of Hypoxia-Induced Transcription.” |
| Degrees
Received: |
B.S., Chemistry,
University of Missouri at St. Louis, May 2001 |
| Honors
Received: |
2007-06,
AFPE Pre-Doctoral Fellowship, Achievement Rewards for College
Scientists (ARCS); 2005, Ruth Kirschtein National Research Service
Award; 2001, Alan F. Berndt Outstanding Senior Chemist Award,
American Chemical Society’s Award for Analytical Chemistry,
1st Place in seminar competition at American
Chemical Society’s Undergraduate Research Symposium; 2000,
William and Erma Cooke Chemistry Fellowship, Monsanto Aid to Education
Scholarship in Chemistry |
| AFPE
Award: |
Wyeth Pharmaceuticals
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
CELESTE M. BOLIN |
University
of Montana Skaggs School of Pharmacy |
| Major
|
Pharmacology/Toxicology |
| GPA:
|
3.79/4.00 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To assess
biomarkers and mediators of oxidative stress after neurotoxin
exposure or onset of neurodegenerative disease. The focus of research
is neurotoxicology with a focus oh how oxidative stress, mediated
by reactive oxygen species, damages neurons contributing to neuronal
deficits and neurodegenerative diseases. |
| Title
of Dissertation: |
“Evaluation
of Oxidized GTP and dGTP as Biomarkers and Mediators of Cellular
Dysfunction in Models of Neurotoxin Exposure.” |
| Degrees
Received: |
B.S., Chemistry,
Whitman College, May 2001 |
| Honors
Received: |
2007, P.E.O.
Scholar Award; 2006, AFPE Pre-Doctoral Fellowship; 2005-04, NSF-EPSCoR
Fellowship |
| AFPE
Award: |
Accreditation
Council for Pharmacy Education - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
LAURA N. BONIFACIO |
University
of North Carolina at Chapel Hill School of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
N/A |
| Graduation
Date: |
May 2010 |
| Focus
of Research: |
To elucidate
the etiology of schizophrenia by examining the role of miRNA mediated
regulation of mRNA. Specifically, we will show that regulation
of miRNA processing is altered in neuronal cells of schizophrenia
patients. An understanding of the specific alterations of miRNA
function in schizophrenia may lead to more rapid and accurate
diagnosis, a clearer understanding of disease etiology, and increased
knowledge of the
regulation of miRNA biogenesis. |
| Title
of Dissertation: |
“Regulation
of miRNA Biogenesis and its Role in the Pathophysiology of Schizophrenia.” |
| Degrees
Received: |
Pharm.D.,
University of North Carolina at Chapel Hill, December 2005 |
| Honors
Received: |
2006, Pharm.D.
with highest honors; 2006-04, Sibyl Vorheis Jennings Memorial
Scholarship; 2005, Fred Eschelman Scholarship, Jacobs Award in
Medicinal Chemistry; 2004, Jeffery M. Jordan Memorial Scholars |
| AFPE
Award: |
Fred Eschelman
Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
LISA A. BONNER |
Purdue University School of Pharmacy and Pharmaceutical Sciences |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.88/4.00 |
| Graduation
Date: |
August 2008 |
| Focus
of Research: |
To study
the design and synthesis of dopamine receptor agonists that are
conformationally rigid analogues of dopamine, mimicking its orientation
in the binding site of each of the five different dopamine receptors,
which then allows us to study the functional importance of each
unique receptor. Studying the action of dopamine in
such biological pathways as reward circuits, memory consolidation,
and locomotor control can offer insights into normal functions,
as well as diseases such as addiction, schizophrenia, and Parkinson’s
disease. |
| Title
of Dissertation: |
“Design
and Synthesis of Potential Dopamine D1 Selective Ligands—Molecular
Exploration of Hydrogen-Bonding Networks in D1 versus D2 Dopamine
Receptors.” |
| Degrees
Received: |
B.S., Biochemistry/Chemistry,
Loyola College in Maryland, May 2002 |
| Honors
Received: |
2006, Purdue
University Graduate Student Award for Outstanding Teaching; 2005,
Albert and Anna Kienly Award for Excellence in Teaching; 2003,
Ross Fellowship; 2001, Dean’s Academic Scholarship, Phi
Beta Kappa, Hauber Summer Research Fellowship; 1998, Presidential
Academic Scholarship |
| AFPE
Award: |
Merck Company
Foundation Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
MARK P. BORGMAN |
University
of Maryland, Baltimore School of Pharmacy |
| Major
|
Pharmaceutical
Sciences |
| GPA:
|
3.78/4.00 |
| Graduation
Date: |
August 2009 |
| Focus
of Research: |
To research
targeted delivery of bioactive and diagnostic radionuclides to
solid tumors using polymeric biomaterials. The ability to selectively
target therapeutic agents to tumor tissue using polymeric systems
reduces non-specific toxicity and is a strategy that holds promise
for creating new successful treatments of cancer. |
| Title
of Dissertation: |
“HPMA
Copolymer-Peptide Conjugates for Angiogenesis Targeted Delivery
of Diagnostic and Therapeutic Radionuclides.” |
| Degrees
Received: |
B.S., Medical
Technology, Michigan State University, May 2004 |
| Honors
Received: |
2006, AFPE
Graduate Student Recognition Award, AFPE Pre-Doctoral Fellowship;
2004, Academic Honors Michigan State University Medical Technology;
2004-03, Dean’s Honor Roll |
| AFPE
Award: |
Wyeth - AFPE
Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
KEITH D. CONNAGHAN-JONES |
University
of Colorado Health Sciences Center |
| Major
|
Pharmaceutical
Science |
| GPA:
|
3.7/4.0 |
| Graduation
Date: |
August 2008 |
| Focus
of Research: |
To use molecular
biophysics to understand the mechanisms of transcriptional regulation.
Using Progesterone Receptor (PR) as a model system, I am studying
the role that Na+ and K+ play in PRs ability to activate transcription.
A goal is to correlate PR promoter assembly and PR transcriptional
activity under varying salt conditions. This research will help
provide the knowledge to understand why transcriptional regulation
malfunctions in diseases such as cancer and to help develop new
therapies. |
| Title
of Dissertation: |
“Mechanisms
of Progesterone Receptor: Promoter Assembly.” |
| Degrees
Received: |
B.A., Chemistry,
Colorado College, May 2002 |
| Honors
Received: |
2006, Abstract
Selected for Platform Presentation – Gibbs Conference on
Biothermodynamics; 2005, 2nd Place in Poster Presentation Competition,
Colorado Protein Stability Conference; 2004, NIH Pre-Doctoral
Fellow, Outstanding Graduate Student Oral Presentation at Pharmaceutical
Sciences Departmental Retreat; 2001,
Crown Goodman Presidential Scholarship |
| AFPE
Award: |
Pfizer Inc.
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
KELLY L. DAMM |
University
of Michigan College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.98/4.00 |
| Graduation
Date: |
April 2008 |
| Focus
of Research: |
To evaluate
experimental structures of HIV-1p, NMR ensembles and collections
of x-ray structures, as a source of multiple conformations to
generate receptor-based MPS pharmacophore models. The use of MPS
allows us to sample a range of conformational space and replicate
the inherent flexibility of a protein. The pharmacophore models
will be analyzed to determine features that differentiate susceptible
and resistant strains of HIV-1p. The resulting models will be
screened against large commercially available databases to predict
novel leads for the development of a broad spectrum HIV-1p inhibitor
that can overcome resistance liabilities of existing treatments. |
| Title
of Dissertation: |
“Protein
Flexibility in Structure-Based Drug Design.” |
| Degrees
Received: |
M.S.E., Biomedical
Engineering, University of Michigan, April 2002
B.S.E., Material Science Engineering, University of Michigan,
April, 2002 |
| Honors
Received: |
2007, Rackham
Graduate School Pre-Doctoral Fellowship; 2006, CARAT Learning
Sciences Graduate Student Instructor Fellowship; 2005-04, Harold
and Vivian Shapiro Award, Pharmaceutical Sciences Training Program;
2002-97, Adolf Wurst Engineering Scholarship |
| AFPE
Award: |
Pfizer Inc.
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
NATHANAEL L. DIRKS |
University
of Tennessee College of Pharmacy |
| Major
|
Pharmaceutical
Science |
| GPA:
|
4.0/4.0 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To investigate
and compare the performance of population pharmacokinetic modeling
methods based on maximum likelihood and Bayesian theory in characterizing
nonlinear elimination pharmacokinetics. A comparative performance
study of estimation methods has not been done under the condition
of a POPPK model with nonlinear elimination. |
| Title
of Dissertation: |
“The
Comparative Performance of Population Pharmacokinetics Modeling
Methods Based on Maximum Likelihood and Bevesian Theory in Evaluating
Nonlinear Elimination Pharmacokinetics.” |
| Degrees
Received: |
Pharm.D.,
University of Tennessee College of Pharmacy, May 2005
B.A., Biology, University of Northern Iowa, May 2001 |
| Honors
Received: |
2006, GlaxoSmithKline-AFPE
Pre-Doctoral Fellowship, AFPE Pharmaceutical Sciences Graduate
Student Recognition Award; 2005, Valedictorian, University of
Tennessee College of Pharmacy, Lilly Achievement Award, Medicinal
Chemistry Award; 2004-03, Seldon D. Feurt Memorial Scholarship;
2002, Plough Scholarship, University of Northern Iowa Merchant
Scholarship; 2001, Seldon D. Feurt Scholar (PharmD/PhD Scholarship),
University of Northern Iowa Purple and Old Gold Award |
| AFPE
Award: |
American
Association of Pharmaceutical Scientists (AAPS) - AFPE Pre-Doctoral
Fellowship in the Pharmaceutical Sciences |
DIANE V. DOUGHTY |
University
of Maryland at Baltimore College of Pharmacy |
| Major
|
Pharmaceutical
Science |
| GPA:
|
4.0/4.0 |
| Graduation
Date: |
April 2009 |
| Focus
of Research: |
To determine
and implement parameters for automated nasal spray pump systems
from studies using patients of different ages. The parameters
will be used on the automated systems to determine in vitro measures
of nasal spray performance such as shot weight, droplet size,
and plume geometry. Given the FDA recommendation to use automated
nasal spray pumps t o decrease variability associated with manual
actuations, the determination of parameters for these automated
systems and their relevance to patient
actuation is needed. |
| Title
of Dissertation: |
“Investigation
of Hand Actuation Variability Among Patients of Different Ages
Using Nasal Spray Products and In Vitro Comparison of Nasal Spray
Properties When Units are Hand Actuated or Fired Using Automated
Actuation Systems.” |
| Degrees
Received: |
B.S., Biology,
Pennsylvania State University, December 2004 |
| Honors
Received: |
2007, Rho
Chi Honor Society Induction; 2006, AAPS Sponsored Travel Award;
2004, Theta Kappa Pi Service Award |
| AFPE
AWARD: |
Josiah Kirby
Lilly, Sr. Memorial - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
JAMES A. DOWELL |
University
of Wisconsin School of Pharmacy |
| Major
|
Pharmaceutical
Science |
| GPA:
|
3.85/4.00 |
| Graduation
Date: |
August 2008 |
| Focus
of Research: |
To use advanced
techniques in mass spectrometry to examine neuropeptide expression
changes caused by feeding in rats and to explore the role of neuropeptidergic
signaling in the regulation of reward driven feeding behavior
in rats. Basic research to increase knowledge of feed and its
addictive components has the potential to be relevant to the current
obesity epidemic. |
| Title
of Dissertation: |
“Neuropeptidomics
of Reward Driven Feeding in Rats.” |
| Degrees
Received: |
B.S., Chemistry,
University of Kansas, December 1998 |
| Honors
Received: |
2007-06,
AFPE Pre-Doctoral Fellowship; 2004-03, Mern Kier Fellowship |
| AFPE
Award: |
21st Century
Club – Abe Plough Memorial - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
DEREK A. DRECHSEL |
University
of Colorado at Denver and Health Sciences Center |
| Major
|
Pharmacology/Toxicology |
| GPA:
|
3.87/4.00 |
| Graduation
Date: |
June 2009 |
| Focus
of Research: |
Elucidating
mitochondrial mechanisms that contribute to oxidative stress in
the pathogenesis of Parkinson’s Disease (PD). Several environmental
agents implicated in the etiology of PD are classified as redox
cycling agents capable of generating reactive oxygen species (ROS).
Such redox cycling agents are found both in the environment and
endogenously and exposure is linked with an increased risk of
developing PD. This research focuses on determining novel mitochondrial
mechanisms by which redox cycling agents produce ROS in the brain
and how this process is mediated by genetic factors of PD. The
pathogenesis of PD and other neurodegenerative disorders is associated
with mitochondrial dysfunction and oxidative disease. |
| Title
of Dissertation: |
“Redox
Cycling Agents and Parkinson’s Disease.” |
| Degrees
Received: |
B.S., Biology
– Vertebrate Physiology, Pennsylvania State University,
December 2003 |
| Honors
Received: |
2006, AFPE
Pre-Doctoral Fellowship, Poster Award, International Neurotoxicology
Conference; 2003, Eberly College of Science Student Research Recognition;
2002, USCSA Academic All-American |
| AFPE
Award: |
Ortho-McNeil
Janssen Scientific Affairs - AFPE Pre-Doctoral Fellowship in the
Pharmaceutical Sciences |
MICHAEL E. DUNN |
University
of Rhode Island College of Pharmacy |
| Major:
|
Pharmacology/Toxicology |
| GPA:
|
3.7/4.0 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To study
clopidrogrol, an established and proven human cardiovascular xenobiotic,
and the potential for its therapeutic efficacy to be affected
by the consumption of alcohol, specifically on clopidogrel. The
proposed research will focus on the positive and/or negative pharmacological
and/or toxicological implications of the conversion of Plavix
to ethyl-Plavix as a result of alcohol consumption, in humans.
The goal is to show that alcohol alters the metabolism of clopidogrel
in a manner that lengthens the drugs therapeutic effect with the
potential for toxicity and excessive internal/external bleeding. |
| Title
of Dissertation: |
“The
In Vivo Pharmacological Implications of the Transesterification
of Plavix in the Presence of Ethyl Alcohol.” |
| Degrees
Received: |
M.S., Kinesiology,
University of Rhode Island, May 2006
B.S., Biology, University of Vermont, May 2003 |
| Honors
Received: |
2006, 3rd
Place Poster, Graduate Division; 2003, College Honors at the University
of Vermont; 2000, Dean’s List at the University of Vermont |
| AFPE
Award: |
sanofi–aventis
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
SARAH J. FARNSWORTH |
University
of Utah College of Pharmacy |
| Major
|
Neuroscience |
| GPA:
|
3.9/4.0 |
| Graduation
Date: |
May 2009 |
| Focus
of Research: |
To focus
on the differential effects of the psychostimulants methamphetamine
and methylphenidate on neurotransporter distribution and dopaminergic
neurotransmission, as well as the differences in intracellular
biochemical signaling pathways that mediate these events. The
purpose of the research is to elucidate the underlying differences
in intracellular signaling cascades that may account for the opposite
effects of the drugs
on neurotoxicity. |
| Title
of Dissertation: |
“Molecular
Mechanisms Underlying Psychostimulant-induced Vesicle Trafficking:
Implications for Neurotoxicity and Neurodegenerative Disorders.” |
| Degrees
Received: |
B.S., Psychology,
Weber State University, May 2004 |
| Honors
Received: |
2004, Graduated
Summa Cum Laude, Weber State University; 2003, Denkers Family
Undergraduate Research Fellow Award; 2000, F. Ann Millner Presidential
Scholarship Award, Utah State Board of Education Certificate of
Outstanding Academic Performance, President’s Education
Award, National Honor Society Academic Excellence Award |
| AFPE
Award: |
American
Association of Pharmaceutical Scientists (AAPS) - AFPE Pre-Doctoral
Fellowship in the Pharmaceutical Sciences |
DANIEL P. FLAHERTY |
University
of Nebraska Medical Center Collegeof Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
4.0/4.0 |
| Graduation
Date: |
June 2010 |
| Focus
of Research: |
To develop
novel disease modifying therapeutic agents for the treatment of
Alzheimer’s Disease through the synthesis and characterization
of novel compounds using in vitro and in vivo Alzheimer’s
disease models. Currently, the only treatments for Alzheimer’s
Disease are symptom modifying therapeutic agents. |
| Title
of Dissertation: |
“Styrylbenzenes
as Potential Therapeutics for Alzheimer’s Disease.” |
| Degrees
Received: |
B.A., Chemistry,
Central College, May 2005 |
| Honors
Received: |
2005, Graduated
Summa Cum Laude, Outstanding Senior Chemist, Top Male Athlete
GPA, Central College Baseball Ver Steeg Award |
| AFPE
Award: |
Josiah Kirby
Lilly, Sr. Memorial - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
KEVIN J. FREISE |
University
of Iowa College of Pharmacy |
| Major
|
Pharmaceutics |
| GPA: |
4.0/4.0 |
| Graduation
Date: |
August 2009 |
| Focus
of Research: |
To create
a mechanically based pharmacokinetic/pharmacodynamic mathematical
model of the relationship between erythropoietin and erythropoiesis
in critically ill neonatal infants in order to optimize treatment
of anemia with erythropoietin in these infants. The goal of the
research is to use PK/PD modeling and simulation to optimize drug
therapy and to improve the design and analysis of both preclinical
and clinical studies. |
| Title
of Dissertation: |
“Mechanically
Based Pharmacokinetic/Pharmacodynamic Analysis of Erythropoiesis
and Erythropoietic Compounds.” |
| Degrees
Received: |
M.S., Veterinary
Medical Science, University of Illinois at Urbana-Champaign, May
2004
B.S., Animal Science, University of Illinois at Urbana-Champaign,
December 2001 |
| Honors
Received: |
2005, Presidential
Graduate Fellow; 2002, Bronze Tablet Award; 2002-98 Edmund J.
James Scholar; 2001, Senior 100 Honorary; 2000, 1st Place Invitational
Research paper at Undergraduate Paper Competition for Midwest
American Society of Animal Sciences, J. Baldwin Turner Undergraduate
Research Grant |
| AFPE
Award: |
Johnson &
Johnson Pharmaceutical R & D - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
AMBER M. GOEDKEN |
University
of Iowa College of Pharmacy |
| Major
|
Social &
Administrative Sciences |
| GPA:
|
4.0/4.0 |
| Graduation
Date: |
May 2010 |
| Focus
of Research: |
To focus
on the impact of prescription drug benefit plan structures on
medication use and health outcomes, particularly in terms of how
cost-sharing affects the use of medications by elderly Medicare
beneficiaries. Given the enrollment of Medicare beneficiaries
in numerous prescription drug benefit plans, the goal of this
research is to understand the implications of the various prescription
drug benefit plan structures on medication use by Medicare beneficiaries. |
| Title
of Dissertation: |
“Effect
of Type and Amount of Cost-Sharing on Congestive Heart Failure
Prescriptions and Hospitalizations Among Medicare Beneficiaries
Enrolled in Nationwide Stand-Alone Prescription Drug Plans.” |
| Degrees
Received: |
Pharm.D.,
University of Iowa, May 2004 |
| Honors
Received: |
2007, Outstanding
Teaching Assistant Award, 3rd Place in Biological & Health
Science Division at the James F. Jakobsen Graduate Conference;
2005, AACP Wal-Mart Annual Conference Scholarship |
| AFPE
Award: |
PhRMA Foundation
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
DAVID J. GOOD |
University
of Michigan College of Pharmacy |
| Major: |
Pharmaceutics |
| GPA: |
4.06/4.30 |
| Graduation
Date: |
March 2010 |
| Focus
of Research: |
To determine
the mechanisms by which moisture can generate pharmaceutical cocrystals
when solid particles of cocrystal reactants are exposed to moisture
rich conditions. This project involves understanding the thermodynamic
and kinetic principles associated with the phase transformations
as solid blends evolve into solutions which lead to crystallization
or dissolution of cocrystals. This understanding is critical to
formulating stable solid dosage forms of cocrystals. Cocrystals
are increasingly interesting for development of solubility, stability,
or other physical chemical crystal properties not adequately addressed
by salt formation or other methods. |
| Title
of Dissertation: |
“Determination
of the Kinetics, Thermodynamics, and Mechanisms of Moisture Induced
Phase Transformations relating to the Formation and Stability
of Pharmaceutical Cocrystals.” |
| Degrees
Received: |
M.S., Pharmaceutical
Chemistry, Lehigh University, January 2004
B.S., Chemistry, Allegheny College, May 2001 |
| Honors
Received: |
2003, ICI
Innovation Award; 2001, Graduated Cum Laude, Honors in Chemistry;
1999-97, Alden Scholar |
| AFPE
Award: |
Pfizer Inc.
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
PETE P. GUERRIERI |
Purdue
University School of Pharmacy |
| Major
|
Pharmaceutics |
| GPA:
|
3.7/4.0 |
| Graduation
Date: |
June 2009 |
| Focus
of Research: |
To investigate
the underlying mechanism governing moisture uptake in pharmaceutical
salts and concomitantly investigate the physico-chemical state
of water at the surface including in the presence of excipients.
The goals are to obtain a more comprehensive definition of the
term hygroscopicity, to better understand the specific phenomena
responsible for chemical and physical instability and to apply
the knowledge gained to predict the interaction of pharmaceutical
salts with various types of excipients and how this interaction
impacts chemical stability. Various surface analytical techniques
will be explored in relation to these goals. |
| Title
of Dissertation: |
“Investigation
of the Fundamental Basis of Hygroscopicity in Pharmaceutical Salts
and the Consequent Impact on Physical and Chemical Stability.” |
| Degrees
Received: |
B.Sc., Chemical
Engineering, Minor in Chemistry, Widener University, May 2003 |
| Honors
Received: |
2003, Graduated
Magna Cum Laude, American Chemical Society Award for Chemical
Engineering; 2003-99, Dean’s List; 2002, Induction into
Tau Beta Pi and Sigma Pi Honor Societies |
| AFPE
Award: |
21st Century
Club - Richard E. Faust Citation - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
IGOR GUREVICH |
University
of Connecticut Storrs School of Pharmacy |
| Major
|
Pharmacology/Toxicology |
| GPA:
|
3.74/4.00 |
| Graduation
Date: |
May 2009 |
| Focus
of Research: |
To focus
on mechanisms of interaction between retinoid receptors and a
novel coregulator recently isolated by our laboratory, and mechanisms
by which this coregulator mediates transcriptional repression.
The novelty of this coregulator stems from its action as a corepressor
of retinoic acid receptors (RAR) and peroxisome proliferator activated
receptors (PPAR) in the presence of ligands. |
| Title
of Dissertation: |
“Mechanisms
of Corepressor Recruitment by Nuclear Retinoid Receptors.” |
| Degrees
Received: |
B.S., Food
Science, University of Massachusetts Amherst, May 2000 |
| Honors
Received: |
2007-06,
Johnson & Johnson Pharmaceutical R & D AFPE Pre-Doctoral
Fellowship, Boehringer Ingelheim Pharmaceuticals, Inc. Pre-Doctoral
Fellowship in Pharmaceutical Sciences |
| AFPE
Award: |
American
Pharmacists Association - AFPE Pre-Doctoral Fellowship in the
Pharmaceutical Sciences |
SHUMET A. HAILU |
University
of Connecticut Storrs School of Pharmacy |
| Major
|
Pharmaceutics |
| GPA:
|
3.91/4.00 |
| Graduation
Date: |
May 2009 |
| Focus
of Research: |
To focus
on better understanding of the factors and mechanisms involved
in stabilization and/or destabilization of amorphous drugs prepared
with silicates, so as to improve chemical stability by proper
selection of silicates with the required properties and/or optimization
of formulation parameters. Recently, several silicates have been
investigated for preparation of physically stable amorphous drugs
with successful results. This study addresses the chemical stability
problem by seeking to achieve formulation development of both
chemically and physically stable drugs amorphized with silicates. |
| Title
of Dissertation: |
“Chemical
Stability of Pharmaceuticals Amorphized with Silicates.” |
| Degrees
Received: |
M.S., Pharmaceutics,
Addis Ababa University, Ethiopia, July 2002
B.S., Pharmacy, Addis Ababa University, Ethiopia, July 1998 |
| Honors
Received: |
2006, USP
Fellowship; 2004, University of Connecticut Graduate School Multicultural
Fellowship; 2001, German Academic Exchange Program Research Fellowship |
| AFPE
Award: |
Johnson &
Johnson Pharmaceutical R & D - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
NICHOLAS L. HAMMOND |
University
of Mississippi School of Pharmacy |
| Major:
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.8/4.0 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To focus
on the development of new small molecule pharmaceutical agents
for use in the treatment of cancer and malaria. These small molecules
have been developed using both computer simulations of the Bcl-2
protein and structure based design from previously published work.
The research involves developing a new class of more selective,
more effective, and less toxic agents for the treatment of cancer
as well as developing novel antimalarial agents. |
| Title
of Dissertation: |
“Design
and Synthesis of Inhibitors for the Bcl-2 Family Proteins for
the Treatment of Cancer and Malaria.” |
| Degrees
Received: |
B.S., Biology/Chemistry,
Butler University, May 2000 |
| Honors
Received: |
2007, NCIIA
BMEidea Prototype Stipend, MTA SBIR Phase 0; 2006, Noetic New
Company Award, 1st Place in the Invent Your Future Business Plan
Competition, 3rd Place in the Gillespie Business Plan Competition,
3rd Place in the FedEx Business Plan Competition; 2006-04, NSF
IGERT Trainee; 2004, ACS Outstanding Graduate Student |
| AFPE
AWARD: |
GlaxoSmithKline
Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
WENDY J. HARTSOCK |
University
of Kansas School of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.66/4.00 |
| Graduation
Date: |
January 2010 |
| Focus
of Research: |
To focus
on the elucidation of peptidic ligand binding sites in the delta
opioid receptor. Techniques employed in studying these interactions
include MALDI mass spectrometric peptide mapping of affinity labeled
receptors and Western analysis of protein-peptide complexes. The
research involves determination of receptor-ligand interactions
at the molecular level using state-of-the-art analytical techniques.
Structural studies of membrane bound proteins are gaining importance
as these proteins represent a major class of drug targets and
such studies will facilitate the development of novel peptide-based
therapeutics. |
| Title
of Dissertation: |
“Probing
Receptor-Peptide Interactions of the Delta Opioid Receptor Employing
Dual Labeled Peptide Ligands.” |
| Degrees
Received: |
M.S., Pharmaceutical
Sciences, University of Arizona, August 2005
B.S., Chemistry & Zoology, Northern Arizona University, August
2001 |
| Honors
Received: |
2007, Inducted
into American Peptide Society; 2004, NIH Biological Chemistry
Training Grant; 2001, Phi Lambda Upsilon Honorary Nominee, American
Institute of Chemistry Award |
| AFPE
Award: |
National
Association of Boards of Pharmacy (NABP) - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
KIRK E. HEVENER |
University
of Tennessee Health Science Center |
| Major: |
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.83/4.00 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To focus
on the structure-based design of novel antimicrobial agents; specifically
inhibitors of the bacterial enzyme dihydropteroate synthase (DHPS)
which is a key target in the bacterial folate biosynthesis pathway
and is not found in mammals. The research will use enzyme crystal
structures in a series of computer-aided drug design techniques,
including molecular simulations and virtual screenings, to identify
novel lead compounds which will be synthesized and tested for
activity. This research will focus on the integration of computer-based
methods in structure-guided design and the emerging field of fragment-based
design. |
| Title
of Dissertation: |
“The
Structure-Based Design of Novel Antibacterial Agents.” |
| Degrees
Received: |
B.S., Chemistry,
Tennessee State University, December 2005
Pharm.D., University of Tennessee, May 2005 |
| Honors
Received: |
2006, AFPE
Pre-Doctoral Fellowship, UT HSC Student Service Award; 2005, UT
ASP Outstanding Community Service Award, Who’s Who Among
Students in American Colleges and Universities; 2004, Imhotep
Leadership Society Inductee, Phi Delta Chi Whigham Award; 2003,
Phi Delta Chi Emerging Leader Award, UT ASP Top 10 ASP Member
Award; 2001, Andrew D. Holt Alumni Scholarship Recipient |
| AFPE
Award: |
Daiichi-Sankyo
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
RYOKO HIRAKAWA |
University
of the Pacific Thomas J. Long School of Pharmacy and Health
Sciences |
| Major:
|
Pharmacology/Toxicology |
| GPA:
|
3.82/4.00 |
| Graduation
Date: |
January 2008 |
| Focus
of Research: |
A neuropharmacological
investigation of the possible mechanisms underlying the adverse
CNS effects associated with the use of fluoroquinolone antimicrobial
agents and non-steroidal-anti-inflammatory drugs (NSAIDS). Electrophysiological
recording techniques will be used to determine their actions at
several major receptors and ion channels in the CNS. Ciprofloxacin
(fluoroquinolone) is a first line treatment against anthrax poisoning
and efforts to establish the actions of this drug and NSAIDS will
facilitate treatment. |
| Title
of Dissertation: |
“Electrophysiological
Studies of the Interaction between Fluroquinolone Antibacterials
and NSAIDs at Nerve Cell Receptors and Ion Channels.” |
| Degrees
Received: |
M.S., Biological
Sciences (Physiology), San Jose State University, May 2004
B.S., Biology, Notre Dame de Namur University, May 2001 |
| Honors
Received: |
2007, Travel
Fellowship - IBRO World Congress of Neuroscience, Joined Japanese
Neuroscience Society; 2006, John Shinkai Endowed Graduate Student
Scholarship; 2001, Graduated Cum Laude; 2001-97, Dean’s
List |
| AFPE
Award: |
Josiah Kirby
Lilly, Sr. Memorial - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
JILLIAN H. HURST |
University
of Georgia College of Pharmacy |
| Major
|
Pharmacology/Toxicology |
| GPA:
|
3.9/4.0 |
| Graduation
Date: |
May 2009 |
| Focus
of Research: |
To delineate
the roles of Regulator of G-protein Signaling (RGS) proteins acting
downstream of the D2 dopamine receptor which is involved in multiple
disorders including Parkinson’s disease, schizophrenia and
addiction. The goal is to define the activity and specificity
of downstream effectors of G-protein coupled receptor cellular
signaling pathways. Therapeutic targeting of pathway-specific
signaling molecules will decrease side-effects and enhance the
potency of treatments. |
| Title
of Dissertation: |
"Regulator
of G-protein Signaling (RGS) 9-2 modulation of D2 Dopamine Receptor
Signaling.” |
| Degrees
Received: |
B.S., Chemistry,
Mary Washington College, May 2004 |
| Honors
Received: |
2007, Department
Graduate Student of the Year, Member - Blue Key Honor Society;
2006, AFPE Pre-Doctoral Fellowship; 2005, University-wide Outstanding
Teaching Assistant; 2004, Graduated Cum Laude; 2003, Member -
Chi Beta Phi Science Honor Society; 2000, Mary Washington College
Alumni Scholar |
| AFPE
Award: |
AstraZeneca
Pharmaceuticals - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
NAISSAN HUSSAINZADA |
University
of Maryland at Baltimore College of Pharmacy |
| Major
|
Pharmaceutics |
| GPA:
|
3.8/4.0 |
| Graduation
Date: |
June 2008 |
| Focus
of Research: |
To elucidate
structure/function relationships for human Apical Na+ -dependent
Bile Acid Transporter (hASBT) via mutagenesis and electrophysiology
to determine substrate binding sites and permeation pathways with
eventual development of an ordered binding model. The apical sodium
dependent bile acid transporter is a physiologically important
and clinically relevant transport system. The goal is to use mutagenesis
protocols and electrophysiology to develop a molecular model of
AFT function, thereby enabling rational drug design targeting
of this important carrier. |
| Title
of Dissertation: |
“Optimizing
Drug Delivery to the Intestinal Bile Acid Transporter: Novel Insights
using Structure/Function Studies and Electrophysiology.” |
| Degrees
Received: |
B.A., Biology,
St. Mary’s University of Maryland, June 2001 |
| Honors
Received: |
2006-04,
Dean’s List; 2003, Shire Labs Innovative Young Scientists
Award; 1998-97, Dean’s List; 1997 |
| AFPE
Award: |
United States
Pharmacopeia (USP) - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
PATRICE L. JACKSON |
Howard
University School of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.96/4.00 |
| Graduation
Date: |
August 2008 |
| Focus
of Research: |
To design,
synthesize, and study biologically a novel series of benzene sulfonamide
enaminone derivatives as potential anticonvulsant agents for the
advancement of treatment for epilepsy. Using active enaminone
analogs as potential probes for defining the mechanism of action
of these derivatives will assist in designing more effective anticonvulsant
agents. |
| Title
of Dissertation: |
“Effect
of Isoflavones on Oral Cancer Cell Lines, Premalignant Lesions,
and Adjacent Normal Oral Mucosa: A Mechanistic Study.” |
| Degrees
Received: |
M.Sc., Chemistry,
Tennessee State University, May 2003,
B.S., Chemistry, LeMoyne-Owen College, May 2000 |
| Honors
Received: |
2007, E.A.
Bouchet Graduate Honor Society; 2007-06, AFPE Pre-Doctoral Fellowship;
2006-03, Chauncey Copper Scholarship; 2000, Memphis Chemical Association
Scholarship; 1999, National Dean’s List, US Achievement
Academy Scholar; 1999-98, Dean’s List |
| AFPE
Award: |
Ortho-McNeil
Janssen Scientific Affairs - AFPE Pre-Doctoral Fellowship in the
Pharmaceutical Sciences |
ELIZABETH B. JAMES |
University
of Washington School of Pharmacy |
| Major
|
Pharmaceutical
Science |
| GPA:
|
3.76/4.00 |
| Graduation
Date: |
December
2008 |
| Focus
of Research: |
The history
and impact of the Washington State Preferred Drug List and Therapeutic
Interchange Program as it pertains to the cost and outcomes of
the Uniform Medical population of 170,000 enrollees. Many investigators
have studied the effects of tiered co-pay structures and varying
cost-sharing algorithms as well as restricted formularies in US
health plans. However, no studies have assessed the use of therapeutic
interchange programs (TIPS) for non-Medicaid health plans. This
research will assess the use of Washington State Preferred Drug
List and Therapeutic Interchange Program. |
| Title
of Dissertation: |
“Washington
State Prescription Medication Control Policy Initiatives: History,
Incentives, and Impact.” |
| Degrees
Received: |
Pharm.D.,
University of Texas at Austin, May 2004, Honors
B.S., Biomedical Science, Texas A&M University, August 1998 |
| Honors
Received: |
2007, Magnuson
Scholar; 2004, Facts and Comparisons: Excellence in Clinical Communication
Award, Pharmacy Administration Outstanding Student Award, William
Arlyn and Mary Carol Kloesel Endowed Presidential Scholarship,
North American Intra-fraternal Foundation Lloyd G. Balfour Fellowship;
2003, James T. Doluisio Endowed Presidential Scholarship; 2003-02,
UT College of Pharmacy Patient Counseling Competition winner;
2002, UT College of Pharmacy Honors Program; 1998, Graduated Cum
Laude, Texas A&M University |
| AFPE
Award: |
American
Society of Health-System Pharmacists - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
STEVEN A. KAWAMOTO |
University
of Michigan College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.9/4.0 |
| Graduation
Date: |
June 2009 |
| Focus
of Research: |
The evaluation
of Survivin’s role in the inhibition of apoptosis, development
of in vitro biological screening assays, and synthesis and evaluation
of peptide-based libraries. Survivin protein is selectively over-expressed
in almost all forms of cancer and has been shown to confer resistance
to chemotherapy and radiation therapy. The elucidation of the
precise mechanism by which Survivin inhibits apoptosis may be
useful in the design of novel anti-cancer agents designed to target
Survivin. |
| Title
of Dissertation: |
“Structure
Based Design, Synthesis and Characterization of Small Molecule
Peptide and Non-Peptide Derived Antagonists of Survivin.” |
| Degrees
Received: |
B.S., Chemistry,
Ohio State University, June 2004 |
| Honors
Received: |
2004, University
Regent’s Fellowship, Department of Homeland Security Fellowship,
Sigma Xi Grant in Aid of Research; 2004-03, University Arts and
Sciences Honors Research Scholarship; 2003, MacNevin Memorial
Scholarship, Pressey Honors Research Scholarship; 2002, National
Science Foundation REU Grant |
| AFPE
Award: |
Josiah Kirby
Lilly Sr. Memorial - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
TZIPPORAH M. KERTESZ |
University
of Connecticut School of Pharmacy |
| Major: |
Pharmacology/Toxicology |
| GPA: |
4.0/4.0 |
| Graduation
Date: |
May 2009 |
| Focus
of Research: |
To use the
new high-through put method of metabonomics to identify the complex
causes of Multiple Sclerosis (MS) induction and progression. The
cerebrospinal fluid from the rat model of Myelin Oligodendrocyte
Induced Experimental Autoimmune Encephalomyelitis will be analyzed
to identify biomarkers of disease induction and progression. Samples
from people suffering from MS will be compared to correlate the
animal model to the human disease. The identity of these biomarkers
will be used to explore the metabolic pathways altered in MS to
provide further understanding of the mechanism of the disease
as well as targets for therapeutics. |
| Title
of Dissertation: |
“A
Metabonomic Analysis of Multiple Sclerosis: The Role of Polyamines
in Multiple Sclerosis.” |
| Degrees
Received: |
B.S., Biochemistry,
Worcester Polytechnic Institute, May 2004 |
| Honors
Received: |
2004, President’s
MQP Award, Salisbury Prize; 2004-00, Dean’s List; 2001-00,
Charles O. Thompson Scholar |
| AFPE
Award: |
Merck Company
Foundation Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
ANDREA L. KJOS |
University
of Minnesota College of Pharmacy |
| Major: |
Social &
Administrative Sciences |
| GPA: |
3.86/4.00 |
| Graduation
Date: |
May 2009 |
| Focus
of Research: |
To describe
how patients use both professional and lay social networks as
well as traditional and technologybased sources to obtain medication
information. The research will include a critical examination
of the various communicative processes in order to determine the
occurrence of passive and active information seeking behavior
among patients. The research will contribute to understanding
of consumer health information-seeking behavior, patient participatory
behavior, patient decision-making, and patient-provider communication. |
| Title
of Dissertation: |
“Medication
Information Seeking Behavior: The Role of Social Networks and
Communicative Processes.” |
| Degrees
Received: |
Pharm.D.,
Drake University, May 2005 |
| Honors
Received: |
2004-1999,
Presidential Scholarship; 2003, CVS Scholarship; 2003-99, Dean’s
List; 2002, Walgreens Scholarship; 2001; 1999, Harold Salisbury
Scholarship; 1998, Gold Award – Girl Scouts of America |
| AFPE
Award: |
Ernest Mario
Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
MICHAEL KOCH |
University
of Utah College of Pharmacy |
| Major
|
Pharmacology/Toxicology |
| GPA:
|
3.92/4.0 |
| Graduation
Date: |
December
2008 |
| Focus
of Research: |
To elucidate
the mode of action of exocarpic acid, a naturally occurring plant-derived
polyactylenic fatty acid, against Mycobacterium tuberculosis and
its future use as a pharmacophore for the treatment of diseases
caused by mycobacteria. |
| Title
of Dissertation: |
“Mode
of Action of Exocarpic Acid Against Mycobacterium Tuberculosis.” |
| Degrees
Received: |
MSPH, Public
Health, University of Utah, December 2003
M.S., Biology, University of Michigan, December 1997
B.S., Microbiology, Weber State University, June 1994 |
| Honors
Received: |
1994, School
of Science Valedictorian; 1993, Outstanding Foreign Student Award
& Scholarship, Dean’s List; 1991-90, Dean’s List;
1990, Department Service Award |
| AFPE
Award: |
Teva Pharmaceuticals
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
PHILLIP G. KOPF |
University
of New Mexico College of Pharmacy |
| Major
|
Pharmacology/Toxicology |
| GPA:
|
3.99/4.00 |
| Graduation
Date: |
August 2007
|
| Focus
of Research: |
To examine
the underlying mechanism of the relationship between TCDD exposure
and cardiovascular disease. Human epidemiology studies have correlated
TCDD exposure with cardiovascular disease. This study is unique
in that the exposure regimen is a chronic exposure to lower doses
of TCDD. |
| Title
of Dissertation: |
“The
Effect of Sub-Chronic, Low Level 2,3,7,8 Tetrachlorodibenzo-p-dioxin
(TCDD) on the Development of Cardiovascular Disease.” |
| Degrees
Received: |
B.S., Biology,
Truman State University, May 2001 |
| Honors
Received: |
2006, AFPE
Pre-Doctoral Fellowship; 2005, WERC Fellowship, Joined Society
of Toxicology; 2004, Evans Charitable Trust Scholarship; 2003,
BSGP Pathology Scholar; 1997, Gold Medal in National Russian Essay
Contest; 1996, Silver Medal in National Russian Essay Contest |
| AFPE
Award: |
Procter &
Gamble - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
HILLIARD KUTSCHER |
Rutgers
University Ernest Mario School of Pharmacy |
| Major
|
Pharmaceutical
Science |
| GPA:
|
3.72/4.00 |
| Graduation
Date: |
December
2008 |
| Focus
of Research: |
To develop
a biodegradable nanoparticle aggregate drug delivery system for
intravenous injection which passively targets the lung and actively
targets tumors. This project focuses on creating a nanoparticle
of a biodegradable material as well as a method for aggregating
of these particles in order to make a particle that targets the
lung. Particle biodistribution will be studied using in vivo imaging,
plasma concentrations of an anticancer agent will be determined
by LC/MS MS, and tumor reduction markers will be assessed as the
primary output parameters. In addition, histology samples will
be used to evaluate any adverse inflammation due to the particles.
The structure of the drug delivery system will be engineered to
provide optimized drug release and elimination rates from the
body. |
| Title
of Dissertation: |
“Novel
Tumor-Targeted Nanoparticle Aggregates for the Treatment of Lung
Cancer.” |
| Degrees
Received: |
B.S., Chemical
Engineering, Clarkson University, May 2001 |
| Honors
Received: |
2006-05,
AFPE Pre-Doctoral Fellowship; 2001-97, Presidential Scholar/Scholarship,
Dean’s List; 1997, Eagle Scout |
| AFPE
Award: |
21st Century
Club - Robert Lincoln McNeil Memorial - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
DAVID S. LEE |
Virginia
Commonwealth University School of Pharmacy |
| Major: |
Pharmacokinetics/Metabolism |
| GPA: |
3.78/4.00 |
| Graduation
Date: |
May 2009 |
| Focus
of Research: |
To explore
the pharmacokinetics and pharmacodynamic variability of the cholinesterase
inhibitor, physostigmine, in young and elderly adults and across
several animal species to better understand dosing of cholinesterase
inhibitors for the treatment of Alzheimer’s disease. Increased
understanding of the pharmacokinetic and pharmacodynamic differences
in elderly adults can help improve the clinical outcome of many
pharmaceutical interventions used with older adults. |
| Title
of Dissertation: |
“In-vitro
Pharmacokinetic and Pharmacodynamics Modeling of Physostigmine
in Healthy Young and Elderly Adults.” |
| Degrees
Received: |
B.S., Chemistry,
Georgia Institute of Technology, December 1999 |
| Honors
Received: |
2006, Thacker
Award; 2005-02, School of Pharmacy Dean’s List; 2003, Rho
Chi Induction, “Best Poster Award” |
| AFPE
Award: |
American
Society of Health-System Pharmacists Foundation - AFPE Pre-Doctoral
Fellowship in the Pharmaceutical Sciences |
ANN-MARIE G. MATEI |
St.
John’s University School of Pharmacy |
| Major
|
Pharmacology/Toxicology |
| GPA:
|
3.83/4.00 |
| Graduation
Date: |
June 2008 |
| Focus
of Research: |
There are
few in vitro studies that examine the cytotoxic effects of ziram,
a dithiocarbamate, on different cell systems and no studies that
examine its effects on astrocytes. Dithiocarbamates are compounds
widely used as pesticides, as accelerating agents, and in AIDS
therapy. Acute toxicity studies will be carried out on Ziram including
quantitative estimation of acute toxicity, identification of targets
for toxicity, establishment of the reversibility of the toxic
response, and guidelines of dose ranges for other studies. Immunofluorescence
and scanning electron microscopy will be performed to study cytoskeletal
structures along with several biochemical assays including western
blotting, oxidative stress, and lipid peroxidation. |
| Title
of Dissertation: |
“The
Toxicological Effects of the Dithiocarbamate Compound Ziram on
Rat Hippocampal Astrocytes.” |
| Degrees
Received: |
M.S., Toxicology,
St. John’s University, May 2003
B.S., Pharmacy, St. John’s University, May 1996 |
| Honors
Received: |
2003, Rho
Chi Honor Society; 1995, Dean’s List; 1992-91, Excellence
Scholarship |
| AFPE
Award: |
21st Century
Club - Robert Wood Johnson Memorial - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
BETH M. MILLS |
University
of Iowa College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
4.0/4.0 |
| Graduation
Date: |
December
2008 |
| Focus
of Research: |
To study
interactions between cationic antimicrobial peptides, which have
been found to be instrumental in the clearance of infections,
and polyanion-based therapeutics and glycosaminoglycans. We believe
that specific endogenous glycosaminoglycans and exogenous sulfated
polysaccharide therapeutics are direct and indirect effectors
of specific cationic antimicrobial peptides. Evaluating glycosaminoglycans
and polyanion-based therapeutics for the inhibition of antimicrobial
activity and for the binding affinity for cationic antimicrobial
peptides will help us understand the role that glycosaminoglycans
and polyanionic therapeutics play in modulating the activity of
these important immune system components. |
| Title
of Dissertation: |
“Modulation
of Human Antimicrobial Peptides by Endogenous Glycosaminoglycans
and Saccharidebased Therapeutics.” |
| Degrees
Received: |
B.S., Microbiology
& Biochemistry, Iowa State University, May 2004 |
| Honors
Received: |
2006, AFPE
Pre-Doctoral Fellowship, CBB Pre-Doctoral Fellowship, NMCS Meeting
Travel Grant; 2004, University of Iowa MNPC Fellowship, BBMB Department
Senior Award, Phi Beta Kappa Honor Scoiety Membership; 2002, Shillinglaw
Memorial Scholarship; 2001, Golden Key National Honors Society
Membership, Phi Kappa Phi Honor Society Membership; 1999, State
of Iowa Scholar |
| AFPE
Award: |
Novo-Nordisk
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
SARAH J. NEHM |
University
of Michigan College of Pharmacy |
| Major
|
Pharmaceutics |
| GPA: |
3.73/4.00 |
| Graduation
Date: |
April 2008
|
| Focus
of Research: |
To study
the mechanisms of cocrystallization in the solution-state and
the properties of co-crystals with the goal of developing a rationally-based,
non-empirical method to effectively screen for co-crystals. Co-crystals
are being studied to understand their ability to control the pharmaceutical
properties of a drug via dissolution, solubility, and stability.
A rational method to screen for co-crystals will allow for more
effective processes. |
| Title
of Dissertation: |
“Thermodynamic
and Kinetic Parameters That Explain the Crystallization of Pharmaceutical
Complexes.” |
| Degrees
Received: |
M.S., Pharmaceutical
Sciences, University of Michigan, October 2006
B.S., Pharmaceutical Sciences, Drake University, May 2003 |
| Honors
Received: |
2007-2006,
AFPE Fellow; 2007-2003, Rackham Regents Fellow; 2006-2004, Pharmacological
Sciences Training Program – NIH Pre-Doctoral Training Fellow;
2003, Graduated Magna Cum Laude; 2003-1999, Dean’s and President’s
List |
| AFPE
Award: |
Generic Pharmaceutical
Association (GPhA) - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
SUZANNE T. PHILLIPS |
Virginia
Commonwealth University School of Pharmacy |
| Major
|
Social &
Administrative Sciences |
| GPA:
|
3.78/4.00 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To quantify
a monetary value with antimicrobial resistance in infectious diseases.
Infectious disease experts acknowledge that resistance is a serious
concern, but currently cannot state its importance from an economic
perspective. Knowing the economic impact of antimicrobial resistance
will help hospitals and third party payors better manage the usage
of antimicrobials. |
| Title
of Dissertation: |
“The
Cost of Antimicrobial Resistance in Staphylococcus Aureus Bacteremia.” |
| Degrees
Received: |
B.A., Chemistry,
Washington and Lee University, December 2001 |
| Honors
Received: |
2007, Dean
Victor Yanchick Award; 2006, AFPE Award; 2005-03, Dean’s
List |
| AFPE
Award: |
Consumer
Healthcare Products Association (CHPA) - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
GARRETT R. RETTIG |
University
of Iowa College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.65/4.00 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To incorporate
a nuclear localizing peptide into a non-viral gene delivery vector
and to improve gene transfer efficiency. The research will be
conducted in cell culture and whole-animal assays. The peptide
will be incorporated into pDNA vector in a novel, potentially
universally applicable manner via photo-chemistry. |
| Title
of Dissertation: |
“Non-viral
Gene Delivery Enhanced by a Nuclear Localizing Peptide.” |
| Degrees
Received: |
B.A., Biology,
Wartburg College, May 2003 |
| Honors
Received: |
2007, American
Society Gene Therapy Travel Award; 2006-05, AFPE Pre-Doctoral
Fellowship; 2006, National Medicinal Chemistry Symposium Travel
Award; 2006-04, University of Iowa Pharmacological Sciences Trainee
Award; 2003, University of Iowa Medicinal & Natural Products
Chemistry Award |
| AFPE
Award: |
Johnson &
Johnson Pharmaceutical R&D - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
WENDY L. RICH |
Ohio
State University College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA: |
3.97/4.00 |
| Graduation
Date: |
June 2008 |
| Focus
of Research: |
The regulation
and inhibition of steroid sulfatase (STS), a key enzyme up-regulated
in breast cancer cells. The research will also study the interactions
between STS and other enzymes (aromatase and cyclooxygenase-2)
important in estrogen biosynthesis with the intent of synthesizing
dual-action inhibitors. Blocking multiple targets within the estrogen
synthetic pathway should lead to increased pharmacological effect
and decrease opportunities for “back-up” pathway compensation. |
| Title
of Dissertation: |
“Development
and Biological Evaluation of Estrogen Biosynthesis Enzyme Inhibitors
for Endocrine Therapy of Hormone-Dependent Breast Cancer.” |
| Degrees
Received: |
M.S., Medicinal
Chemistry, Ohio State University, December 2006
B.S., Chemistry, Georgia Institute of Technology, May 2003 |
| Honors
Received: |
2007-2006,
Chih-Ming and Jane Chen Graduate Fellowship in Medicinal Chemistry
and Pharmacognosy, Ohio State Preparing Future Faculty Fellow;
2007-2003, NIH Chemistry-Biology Interface Training Program; 2004-
2003, Ohio State University Fellowship |
| AFPE
Award: |
Procter &
Gamble - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
BRENT L. ROLLINS |
University
of Georgia College of Pharmacy |
| Major
|
Social &
Administrative Sciences |
| GPA: |
3.91/4.00 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To 1). analyze
the amount of time pharmacists spend with patients and the effects
of time spent on patient satisfaction and 2). which factors in
a pharmacy (ex: R.Ph hours, tech tours, computer system, presence
or absence of drive-thru, etc.) most impacts the amount of time
pharmacists are able to spend with patients. This research will
identify the best set of factors in community pharmacy that lead
to pharmacists having the most time with their patients. This
knowledge will be useful in the provision of medication therapy
management services by community pharmacists. |
| Title
of Dissertation: |
“Pharmacists
and Time with Their Patients: Does it Matter?” |
| Degrees
Received: |
B.S.Pharm.,
Pharmacy, Ohio Northern University, May 2004 |
| Honors
Received: |
2007-2006,
AFPE Pre-Doctoral Fellowship; 2004, Graduating Student Faculty
Recognition Award; 2003, Louis D. Vottero Pharmacy Practice Research
Award; 1999, Point Pleasant High School Valedictorian |
| AFPE
Award: |
National
Community Pharmacists Association - AFPE Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
MATTHEW D. SCHMIDT |
University
of Iowa College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.65/4.00 |
| Graduation
Date: |
August 2009 |
| Focus
of Research: |
To incorporate
various aspects of natural product isolation, medicinal chemistry,
organic synthesis, and pharmacology to explore central nervous
system (CNS) active agents. Much of the research will center on
the development of novel analgesics, antidepressants, and drug
abuse therapeutics. Part of the research centers around developing
new compounds with altered levels of tolerance and dependence
that could be potential treatments for drug abuse. |
| Title
of Dissertation: |
“Isolation,
Synthesis and Pharmacological Evaluation of Novel Nicotinic Acetylcholine
Receptor Ligands Based on Gedunin, a Limonoid Found in Azadirachta
Indica.” |
| Degrees
Received: |
B.S., Chemistry;
B.S., Biology; B.S., Pre-Pharmacy, May 2004 |
| Honors
Received: |
2007, National
Scholars Honor Society Inductee; 2007-06, AFPE Pre-Doctoral Fellowship;
2006, NIH Biotechnology Training Grant; 2006-05, Chancellor’s
List; 2005, Center for Biocatalysis and Bioprocessing Pre- Doctoral
Fellowship; 2004, National Dean’s List; 2003, University
Leadership Award; 2002, Pucci Family Biology Scholarship; 2001,
3rd Place at Student Research Symposium |
| AFPE
Award: |
United States
Pharmacopeia (USP) - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
RYAN A. SCHNEIDER |
Ohio
State University College of Pharmacy |
| Major
|
Pharmacology/Toxicology |
| GPA:
|
3.95/4.00 |
| Graduation
Date: |
June 2009 |
| Focus
of Research: |
To create
pharmacological agents called synthetic disintegrins which target
integrin receptors on endothelial cells. These agents could potentially
be used to manipulate and/or disrupt tumor vasculature, and improve
the drug delivery of traditional chemotherapeutic agents. This
project will attempt to target the unregulated integrin receptors
on tumor vasculature, with pharmacological agents. |
| Title
of Dissertation: |
“The
Role of Synthetic Disintegrins in Modulating Tumor Vasculature.” |
| Degrees
Received: |
Pharm.D.,
Ohio Northern University, May 2005 |
| Honors
Received: |
2007, Patil
Fellowship in Pharmacology; 2005, Graduated with High Distinction,
Phi Lambda Sigma – GlaxoSmithKline-AFPE First Year Graduate
Fellowship, Mylan Excellence in Pharmacy Award; 2004, Charles
Oren Lee Prize in Pharmacy Award; 2003, Merck Fellowship for Undergraduate
Research, AFPE Gateway to Research Scholarship, Ohio Pharmacists
Association Leadership Award |
| AFPE
Award: |
GlaxoSmithKline
Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
ANNA L. SCOTT |
University
of Southern California School of Pharmacy |
| Major: |
Pharmacology/Toxicology |
| GPA: |
3.9/4.0 |
| Expected
Graduation: |
May 2009 |
| Focus
of Research: |
To understand
how monoamine oxidase (MAO) and the neurotransmitters regulated
by MAO influence neural stem cells in order to study growth, proliferation,
development and other characteristics of neuronal development.
Stem cells may prove a valuable therapeutic option for neurodegenerative
disease and mental illness in the future, but there is the need
for more understanding of how levels of neurotransmitters in the
brain influence early neuronal development and this research will
contribute to increased knowledge of this process. |
| Title
of Dissertation: |
“Monoamine
Oxidase Regulation of Neural Stem Cells and Brain Development.” |
| Degrees
Received: |
B.S., Biology,
Westmont College, August 2004 |
| Honors
Received: |
2007-05,
Dean’s Fellowship; 2003-01, Presidential Scholarship |
| AFPE
Award: |
Pfizer Inc.
Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
JULIE SCOTT |
University
of Oklahoma Health Sciences Center College of Pharmacy |
| Major
|
Pharmaceutical
Science |
| GPA:
|
3.9/4.0 |
| Graduation
Date: |
August 2008 |
| Focus
of Research: |
To analyze
the recombination protein, RecA, and its role in the induction
and regulation of mismatch repairconverting bacteriophages in
group A streptococci as well as subsequent effects on host phenotype.
This research will contribute to a better understanding of how
resistance occurs by studying the novel mechanism by which group
A streptococci gains antibiotic resistance. |
| Title
of Dissertation: |
“Contribution
of Mismatch Repair (MMR) Converting Prophages to the Host Phenotype
In Group A Streptococci.” |
| Degrees
Received: |
M.S., Cell
Biology, University of Oklahoma, May 2006
B.S., Biochemistry/Molecular & Cellular Biology, University
of Arizona, August 2003 |
| Honors
Received: |
2003, Honors
College Academic Award of Excellence |
| AFPE
Award: |
CVS Caremark
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
SARAH B. SHUGARTS |
University
of California at San Francisco School of Pharmacy |
| Major
|
Pharmacokinetics/Metabolism |
| GPA:
|
3.6/4.0 |
| Graduation
Date: |
June 2009 |
| Focus
of Research: |
To focus
on the efflux transport mediated by the Organic Anion Transporting
Polypeptide (OATP) family of proteins expressed on the hepatic
basolateral membrane and how this efflux affects drug disposition.
This research relates directly to current and future drug development
trends in trying to predict factors that affect drug distribution,
metabolism, and excretion as well as factors that lead to drug-drug
interactions. |
| Title
of Dissertation: |
“Characterizing
the Importance of Hepatic Basolateral Efflux Mediated by the Organic
Anion Transporting Polypeptides (OATPs).” |
| Degrees
Received: |
BS, Chemistry,
Shippensburg University, May 1999 |
| Honors
Received: |
1999, Graduated
Cum Laude, I.M. Kolthoff Award for Analytical Chemistry; 1999-1995,
Shippensburg University Foundation Scholar; 1998, Undergraduate
Award in Analytical Chemistry |
| AFPE
Award: |
Healthcare
Distribution Management Association (HDMA) - AFPE Pre-Doctoral
Fellowship in the Pharmaceutical Sciences |
BASIL A. SMITH |
Florida
A&M University College of Pharmacy and Pharmaceutical Sciences |
| Major: |
Pharmacology/Toxicology |
| GPA: |
3.89/4.00 |
| Expected
Graduation: |
August 2008 |
| Focus
of Research: |
To determine
if NFkB regulates an alternate pathway of cell death involving
the lysosomal proteases cathepsins B and D, during oxidative stress-induced
apoptosis in SHSY5Y cells. The effort to elucidate alternative
pathways of cell death following oxidative stress may produce
therapeutic targets to prevent or retard neurodegeneration following
a stroke or as observed in Alzheimer’s and Parkinson’s
Disease. |
| Title
of Dissertation: |
“Alterations
in the Lysosomal Proteases (cathepsins B & D) and NFkB During
Oxidative Stress-induced Neuronal Death.” |
| Degrees
Received: |
B.S., Biology,
York College, N.Y., May 2000
Associates Degree, Pharmacy, University of Guyana, September 1984
Associates Degree, Nursing, Georgetown Hospital School of Nursing,
Guyana, September 1980 |
| Honors
Received: |
2000, Certificate
of Academic Honors in Biology; 2000-1997, National Dean’s
List; 1998, Who’s Who Among Students in American Colleges
and Universities |
| AFPE
Award: |
American
Association of Colleges of Pharmacy - Pre-Doctoral Fellowship
in the Pharmaceutical Sciences |
LESLIE B. STUART, Jr. |
University
of Tennessee Health Science Center College of Pharmacy |
| Major
|
Pharmaceutical
Science |
| GPA:
|
3.73/4.00 |
| Graduation
Date: |
December/May
2007/2008 |
| Focus
of Research: |
The first
stage of the research project is to characterize the NF-kB mediated
response of alveolar epithelial type II (AEII) cells to TNF-a
and modulation of this response by the novel compound KM-233.
The second stage of research will be the selection of KM-233 analogs
with comparable in vitro activity and structural modifications
to confer increased metabolic stability. Compounds with anti-inflammatory
effects resulting in reduced leukocyte recruitment and/or activation
have potential benefits for acute and chronic inflammatory conditions
associated with overzealous leukocyte response. |
| Title
of Dissertation: |
“Target
Identification and Anti-Inflammatory Effects of Novel Compounds
on Alveolar Epithelial Type II Cells: Effect of Structural Modification
on Target, Activity, and Metabolic Stability.” |
| Degrees
Received: |
Pharm.D.,
University of Tennessee, May 2005
B.S., Biology, University of Tennessee, August 1996 |
| Honors
Received: |
2006, Inducted
in Rho Chi Pharmacy Fraternity; 2004-2001, Seldon D. Feurt Memorial
Fund Scholar |
| AFPE
Award: |
Ernest Mario
Endowed - Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
KEVIN J. TIDGEWELL |
University
of Iowa College of Pharmacy |
| Major
|
Medicinal/Pharmaceutical
Chemistry |
| GPA:
|
3.82/4.00 |
| Graduation
Date: |
August 2008 |
| Focus
of Research: |
To study
the structure-activity relationships of agents that bind with
drug receptors (e.g. dopamine transporter, opioid receptors, specifically
with drugs of abuse, in order to advance the development of novel
analgesics with decreased potential for tolerance and dependence
as well as to advance the development of novel drug abuse therapeutics.
The research will include pharmacological investigations of mechanisms
and anti-nociception of pain, both chronic and acute. |
| Title
of Dissertation: |
“Design,
Synthesis and Evaluation of Novel Mu Opioid Ligands Based on the
Neoclerodane Diterpene Salvinorin A.” |
| Degrees
Received: |
B.S., Chemistry,
Minor in Mathematics, Mercyhurst College, May 2003 |
| Honors
Received: |
2006-2005,
AFPE Pre-Doctoral Fellowship; 2006, National Medicinal Chemistry
Symposium Travel Award; 2005, INRC Travel Award, Pharmacy Graduate
Program Excellence Award; 2004, Pharmacological Sciences Training
Grant, ACS Medicinal Chemistry Travel Grant; 2003, MNPC Fellowship,
Mercyhurst College President’s Award; 2003-1999, Dean’s
List |
| AFPE
Award: |
IMS Health
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
DEEPALI VARTAK |
University
of Illinois at Chicago College of Pharmacy |
| Major:
|
Pharmaceutical
Sciences |
| GPA:
|
4.0/4.0 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To test the
hypothesis that co-overexpression of integrins and matrix metalloproteases
(MMPs) by angiogenic endothelial cells and certain cancer cells
can be utilized for dual specific targeting of solid tumors. A
peptide prodrug that can bind to integrins and be cleaved by MMPs
to deliver multiple therapeutic agents selectively to the tumor
tissue is being evaluated. The delivery of drugs selectively to
the organ, tissue, and cells of the disease while avoiding side
effects t o their healthy counterparts is the goal. This research
examines whether combining multiple targeting strategies will
increase the efficiency and efficacy of the drug delivery system. |
| Title
of Dissertation: |
“Dual
Specific Targeting of Solid Tumors.” |
| Degrees
Received: |
M.S., Pharmaceutics,
Duquesne University, May 2001
M.S., Pharmaceutical Science, Medicinal & Natural Products,
University of Mumbai, India, December 1997
B. Pharmaceutical Science, Pharmaceutical Sciences, University
of Mumbai, India, December 1995 |
| Honors
Received: |
2007, 1st
Place in Sigma Xi Graduate Student Research Forum, Paul Sang Award
in College of Pharmacy, AFPE Pharmaceutical Sciences Graduate
Student Recognition Award; 2006, GlaxoSmithKline-AFPE Pre- Doctoral
Fellowship, Van Doren Scholar Award, University Fellowship; 2005,
AAPS-PDD Section Travel Award for Poster Presentation at the 2005
AAPS annual meeting in Nashville, TN |
| AFPE
Award: |
National
Association of Chain Drug Stores Foundation - AFPE Pre-Doctoral
Fellowship in the Pharmaceutical Sciences |
AMY E. WALTHOUR |
University
of Georgia College of Pharmacy |
| Major
|
Social &
Administrative Sciences |
| GPA:
|
4.0/4.0 |
| Graduation
Date: |
August 2009 |
| Focus
of Research: |
To focus
on health economics, pharmacoeconomics and outcomes research associated
with pharmacological interventions for chronic and debilitating
diseases such as mental illness. This research will evaluate the
effectiveness of initiatives and policies designed to control
pharmaceutical costs at the patient-level and at the economic-level. |
| Title
of Dissertation: |
“Outcomes
Associated with State-Level Health Policy Changes for the Atypical
Antipsychotics Class Drugs within the Georgia Medicaid Population.” |
| Degrees
Received: |
B.S., Biology,
Kennesaw State University, May 2002
A.S., Chemistry, Chattanooga State Technical College, August 2000 |
| Honors
Received: |
2007, AFPE
Pre-Doctoral Fellowship; 2006, Rho Chi Inductee; 2002, Outstanding
Biology Major, Outstanding Senior in Biology, Outstanding Oral
Presentation; 2001, President’s Award – ASM; 2000,
Chemistry Merit Award, Student Excellence Award |
| AFPE
Award: |
Pfizer Inc.
Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
KUANGSHI WU |
University
of Utah College of Pharmacy |
| Major
|
Pharmaceutics |
| GPA:
|
3.91/4.00 |
| Graduation
Date: |
June 2010 |
| Focus
of Research: |
To develop
hybrid hydrogel carriers for protein drugs that can self-assemble
and control drug release after subcutaneous administration. Protein
domains will be grafted onto the polymeric backbones to construct
stimuli-sensitive hybrid hydrogels via coiled-coil formulation,
which work as drug depot to protect enzyme sensitive drugs and
adjust their release upon physiological changes. This research
will construct a series of “smart” hybrid material
that can protect drugs from degradation and control their release
from the depot. |
| Title
of Dissertation: |
“Hybrid
Hydrogels Self-assembled from HPMA Copolymers Containing Coiled-Coil
Grafts.” |
| Degrees
Received: |
M.S., Pharmaceutics,
Peking University Health Science Center, July 2003
B.S., Pharmacy, Peking University Health Science Center, July
2000 |
| Honors
Received: |
2002, Student
of Excellence – Highest Honor; 2000, Excellent Undergraduate
Thesis |
| AFPE
Award: |
Merck Company
Foundation Endowed - AFPE Pre-Doctoral Fellowship in the Pharmaceutical
Sciences |
JOHN S. YANUSAS |
University
of Rhode Island College of Pharmacy |
| Major
|
Pharmaceutics |
| GPA:
|
3.8/4.0 |
| Graduation
Date: |
May 2008 |
| Focus
of Research: |
To develop
an understanding of peptide biopharmaceutical kinetics and mechanisms
of transport of the biopharmaceutical drugs through the para cellular
tight junction complex in nasal and pulmonary drug delivery. Of
particular interest is the use and modification of natural polymers
as enhancers and muco adhesives as they apply to nasal delivery
technology. A nasal in-vitro cell culture model will be used to
monitor and measure the effects when polysaccrides of various
charge, chain length, and structure are incorporated into the
formulation. It is hypothesized that use of natural polymers (polysaccrides)
in pharmaceutical formulations will improve bioavailability by
increasing residency in the mucus layer and increasing paracellular
transport through the tight junction complex. Improvements in
bioavailability for peptide and protein formulations delivered
nasally can reduce or eliminate the administration of the active
pharmaceutical drugs delivered parenterally. This research will
increase understanding of the kinetics and dynamics of peptide
macromolecule nasal drug delivery. |
| Title
of Dissertation: |
“Modulation
of the Nasal Tight Junction Complex Using a Novel Natural Polymer
with other Permeation Enhancers & Mucoadhesives.” |
| Degrees
Received: |
MBA, Business,
University of Rhode Island, December 2003
B.S., Chemistry/Chemical Engineering, University of Connecticut,
December 1986 |
| Honors
Received: |
2007-2006,
AFPE Pre-Doctoral Fellowship; 2004, Beta Gamma Sigma |
| AFPE
Award: |
Teva Pharmaceuticals
- AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences |
