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2007-08 AFPE Gateway Research Scholarship Winners

SANIYA AGGARWAL
Temple University School of Pharmacy
Faculty Sponsor: Scott M. Rawls, Ph.D.
Faculty Sponsor Title: Assistant Professor, Pharmacology
Major: Pharm.D.
GPA: 3.86/4.00
Expected Graduation: May 2010

Focus of Research:

To determine if agmatine enhances the analgesic effect of cannabinoid administration and if it also eliminates addictive qualities and withdrawal effects of cannabinoid. The most clinically relevant focus of this research project is to determine if agmatine prevents the development of tolerance to the analgesic effects of repeated annabinoid administration. If is determined that agmatine administration alters the pharmacologic effects of marijuana and cannabinoid agonists, then the endogenous agmatine system will be identified as a key drug target for treating tolerance and addiction.
Title of Research: “Agmatine Regulation of Cannabinoid Analgesia.”
Degrees Received: Pre-Pharmacy, Temple University, May 2006
Honors Received: 2006-2004, Dean’s List; 2006, Honors Completion Award; 2004, Edward Seidel Math Award, Bordentown Regional Teacher Assistant Award, Deborah Heart & Lung Healthcare Scholarship
AFPE Award: American Association of Pharmaceutical Scientists - AFPE Gateway To Research Scholarship

DIANA X. CAO
University of Southern California School of Pharmacy

Faculty Sponsor: Wei-Chiang Shen, Ph.D.
Faculty Sponsor Title: Professor, Pharmaceutical Sciences
Major: Pharm.D.
GPA: 4.0/4.0
Expected Graduation: May 2009
Focus of Research: To elucidate the signal transduction pathway that eventually leads to the transcription of pro-apoptotic factors. Insight into this pathway may contribute to the development of novel therapeutic approaches to improve the outcome of cancer therapy.
Title of Research: “A Novel Pro-Apoptotic Pathway Modulated by ATM and SUMOylation.”
Degrees Received: B.S., Biochemistry and Molecular & Cellular Biology, University of California at Davis, December 2005
Honors Received: 2007, Rho Chi Book Award; 2006, Alvah Hall Endowment Scholarship, Paul Davis Endowed Scholarship, Graduation with Departmental Citation; 2003, James and Leta Fulmor Scholarship, M.L. Bailey Memorial Scholarship
AFPE Award: AstraZeneca Pharmaceuticals - AFPE Gateway To Research Scholarship

JUSTIN M. JULIUS
Duquesne University Mylan School of Pharmacy
Faculty Sponsor: Paula A. Witt-Enderby, Ph.D.
Faculty Sponsor Title: Associate Professor, Pharmacology/Toxicology
Major: Pharm.D.
GPA: 3.85/4.00
Expected Graduation: May 2009
Focus of Research: To further define the binding pockets of the human MT1 and MT2 melatonin receptors using novel melatonin receptor ligands to develop novel and subtype-selective ligands to further define the role of melatonin within the body, beyond current understanding of its use as a sleep aid.
Title of Research: “Pharmacological Evaluation of 13a, 14 dihydro-6H-pyrazino (1,2-a;4,5-a) diindole Analogs as Melatonin Receptor Ligands Using Competition Binding Analysis and Recombinant Cell Lines Expressing the Human MT1 and MT2 Melatonin Receptors.”
Degrees Received: N/A
Honors Received: 2007-2003, Dean’s List

AFPE Award: American Association of Colleges of Pharmacy - AFPE Gateway to Research Scholarship

BRYAN R. KUDLAWIEC
Duquesne University Mylan School of Pharmacy
Faculty Sponsor: Aleem Gangjee, Ph.D.
Faculty Sponsor Title: Professor, Medicinal Chemistry
Major: Pharm.D.
GPA: 3.98/4.00
Expected Graduation: May 2010
Focus of Research: To develop and research compounds possessing anti-tumor activity that target many sites of cancer cells and produce cancer cell death. One goal is to research compounds that possess multiple binding sites to induce cell death through many cyto-toxic mechanisms. Another goal is to research compounds that create cell death specific to only cancer cells while harming very little normal cells in the human body.
Title of Research: “Synthesis of Tyrosine Kinase Inhibitors as Anti-Tumor Agents.”
Degrees Received: N/A
Honors Received: 2007-05, Dean’s List; 2005, Directors Circle, Phi Eta Sigma - Freshmen Honor Society; 2004, Duquesne Merit Scholarship
AFPE Award: Johnson & Johnson Pharmaceutical R&D - AFPE Gateway To Research Scholarship

PHUONG L. H. NGUYEN
Southern Illinois University at Edwardsville School of Pharmacy
Faculty Sponsor: Guim Kwon, Ph.D.
Faculty Sponsor Title: Assistant Professor, Pharmaceutical Sciences
Major: Pharm.D.
GPA: 3.82/.4.00
Expected Graduation: May 2010
Focus of Research: To elucidate molecular mechanisms involved in the reduction of pancreatic beta-cell mass associated with obesity-mediated Type 2 diabetes and to test the hypothesis that elevated glucose concentrations cause MTOR-mediated hyperplasia that leads to beta-cell death due to the cell cycle or mitochondrial defect. The goal is to contribute to the development of anti-diabetic agents that prevent the onset of Type 2 diabetes by preserving pancreatic beta-cell mass.
Title of Research: “Mechanisms Involved in Glucotoxicity-Mediated Beta-Cell Failure During the Pathogenesis of Obesity-Mediated Type 2 Diabetes.”
Degrees Received: B.A., Chemistry, Saint Louis University
Honors Received: 2007, 2004-03, Dean’s List; 2002, Phi Theta Kappa
AFPE Award: Pfizer Inc. - AFPE Gateway To Research Scholarship

NEENA S. PHADKE
Purdue University School of Pharmacy and Pharmaceutical Sciences
Faculty Sponsor: James E. Tisdale, Pharm.D.
Faculty Sponsor Title: Professor, Pharmacy Practice
Major: Pharm.D.
GPA: 3.95/4.00
Expected Graduation: May 2010
Focus of Research: To determine the efficacy and safety of amiodarone for prevention of atrial fibrillation (AF) after noncardiac thoracic surgery (NCTS), to determine the influence of atrial fibrillation prevention on duration of hospital stay, and to determine predictors and mechanisms of post-NCTS atrial fibrillation. This clinical study is enrolling 240 patients undergoing NCTS.
Title of Research: “Prevention and Mechanisms of Atrial Fibrillation Following Noncardiac Thoracic Surgery.”
Degrees Received: N/A
Honors Received: 2007-04, Dean’s List; 2007, Mortar Board Senior Honor Society, Order of Omega Greek Leadership Honor Society; 2006, Rho Chi Honor Certificate; 2004, National Merit Scholar
AFPE Award: Pfizer Inc. - AFPE Gateway To Research Scholarship

CONNIE M. REMSBERG
Washington State University College of Pharmacy
Faculty Sponsor: Neal M. Davies, Ph.D.
Faculty Sponsor Title: Associate Professor, Medicinal/Pharmaceutical Chemistry
Major: Pharm.D.
GPA: 4.0/4.0
Expected Graduation: May 2010
Focus of Research: To focus on several hydrophobic xenobiotics: paclitaxel, pterostilbene, and phloretin. The in vitro efficacy of pterostilbene and phloretin will be examined in combination with paclitaxel in a spectrum of breast cancers. The pharmacokinetics, tissue distribution, and tolerable dose of polymeric micelle formulations of paclitaxel, pterostilbene, and phloretin will also be determined. Finally, pterostilbene and phloretin will be examined in combination with paclitaxel and alone in mouse xenografts. This research reflects the increased emphasis on research of xenobiotics found in natural products as they may provide antioxidant, anti-cancer, anti-inflammatory, and other health benefits.
Title of Research: “Pharmaceutical Engineering of Nanocarriers for Delivery of Hydrophobic Xenobiotics.”
Degrees Received: B.S., Biology, University of Idaho, May 2006
Honors Received: 2006, Sigma Xi Undergraduate Scholar Award; 2006-05, Undergraduate Student Poster Presentation Winner; 2005, Dr. Paul Ellis Memorial Scholarship; 2005,03, Charlie Langer and Ella Boyle Stanley Scholarship
AFPE Award: Ortho-McNeil Janssen Scientific Affairs - AFPE Gateway To Research Scholarship

JESSE R. RICKELMAN
University of Illinois at Chicago College of Pharmacy
Faculty Sponsor: Richard A. Gemeinhart, Ph.D.
Faculty Sponsor Title: Assistant Professor, Biopharmaceutical Sciences
Major: Pharm.D.
GPA: 3.72/4.00
Expected Graduation: May 2008
Focus of Research: To determine optimal characteristics of hydrogels as effective drug delivery devices with limited side effects by focusing on the release of chemotherapeutic drugs from a polymeric device. The activation of the chemotherapeutic drugs will be mediated by matrix metalloproteases that are released from tumors. The specific goal of the research is to optimize the matrix metalloprotease sensitivity of the hydrogel therapeutics and to optimize the hydrogel parameters within the hydrogel therapeutics. The utilization of hyrogels as drug delivery devices may be a significant innovation in providing localized drug therapy.
Title of Research: “Drug Activation from Hydrogel Therapeutics.”
Degrees Received: N/A
Honors Received: N/A
AFPE Award: Frederick W. Telling Endowed - AFPE Gateway To Research Scholarship

NICOLE SALATA
University of Illinois at Chicago College of Pharmacy
Faculty Sponsor: Hayat Onyuksel, Ph.D.
Faculty Sponsor Title: Professor, Pharmaceutics and Bioengineering
Major: Pharm.D.
GPA: 3.38/4.00
Expected Graduation: May 2010
Focus of Research: To further investigate a previously developed nanomedicine for Alzheimer’s Disease in three ways by first, determining if intranasal delivery is feasible in transgenic mice; second, by determining the appropriate in vivo therapeutic dose in transgenic mice using intranasal delivery; and third, by determining the in vivo safety and efficacy of the nanomedicine in transgenic mice specific to Alzheimer’s Disease, using intranasal delivery.
Title of Research: “In Vivo Efficacy of Novel Bifunctional Nanomedicine for Alzheimer’s Disease in Transgenic Mice Model.”
Degrees Received: B.A., Spanish, University of Illinois at Urbana-Champaign, May 2005
Honors Received: 2004-03, Dean’s List; 2003,01, General Assembly Scholarship; 2001, Illinois State Scholar
AFPE Award: sanofi-aventis - AFPE Gateway To Research Scholarship

THOMAS SHUM
Purdue University School of Pharmacy and Pharmaceutical Sciences
Faculty Sponsor: Arun K. Ghosh, Ph.D.
Faculty Sponsor Title: Professor, Medicinal Chemistry
Major: B.S., Pharmaceutical Sciences
GPA: 3.83/4.00
Expected Graduation: May 2009
Focus of Research: To create an inhibitor for the neuraminidase enzyme in the HPAI A(HN51) influenza virus using a structure-based organic synthesis. The research will involve collaborating with other researchers to obtain protein crystal structure analysis of the binding affinity between synthesized molecules and the target enzyme.
Title of Research: “Design and Synthesis of Neuraminidase Inhibitors Targeting the H5N1 Avian Influenza Strain.”
Degrees Received: N/A
Honors Received: 2007, Eli Lilly Merit Scholarship; 2006-05, Dean’s List
AFPE Award: American Association of Pharmaceutical Scientists - AFPE Gateway To Research Scholarship

CHARLES S. VENUTO
State University of New York at Buffalo School of Pharmacy and Pharmaceutical Sciences
Faculty Sponsor: Gene D. Morse, Pharm.D.
Faculty Sponsor Title: Professor; Chair, Associate Dean, Clinical Education and Research
Major: Pharm.D.
GPA: 3.6/4.0
Expected Graduation: May 2010
Focus of Research: Genetic variations of the MDR1 gene encoding for the membrane efflux pump, P-glycoprotein, and the genes encoding CYP3A4, provide pharmacokinetic consequences when optimizing drug regimens. This variation is further implicated in HIV-infected individuals taking antiretroviral therapy such as protease inhibitors. By associating the genetic polymorphisms with the expression of P-glycoprotein and CYP3A4, this research will seek to obtain a more specific and accurate metabolism profile, allowing therapeutic adjustments and optimal therapy to proceed in HIV-infected patients.
Title of Research: “Pharmacogenomics of Protease Inhibitors in Patients with HIV infection.”
Degrees Received: B.S., Molecular and Microbiology, University of Central Florida, May 2006
Honors Received: 2006, School of Pharmacy Dean’s List; 2006-02, Bright Futures Scholarship
AFPE Award: Pfizer Inc. - AFPE Gateway To Research Scholarship

TYLER R. WHISMAN
University of Kentucky College of Pharmacy
Faculty Sponsor: Wendell S. Akers, Pharm.D.
Faculty Sponsor Title: Associate Professor, Pharmacy Practice and Science
Major: Pharm.D.
GPA: 3.91/4.00
Expected Graduation: May 2008
Focus of Research: To evaluate the concentration-dependent effects of RB006 and RB007 on platelet function in human blood samples. A secondary objective of this study is to compare the effects of anticoagulating blood samples with sodium citrate, PPACK or RB006 on resting and agonist-induced platelet activation. An aptamer (RB006) and complementary antidote (RB007) that inhibits Factor Xia has been recently developed to test in humans. The purpose of this research is to evaluate their ex vivo effect on platelet function and modify the responsiveness to antiplatelet agents.
Title of Research: “The Effect of RB006 and RB007 on In Vitro Platelet Activation in Human Blood.”
Degrees Received: B.A., Biology, Thomas More College, May 2004
Honors Received: 2007, Dean Earl P. Slone Award, Albert Turk Award; 2006, Runner-up NCPA Pruitte-Schutte Business Plan Competition, ASHP National Student Leadership Award; 2005, Kappa Psi Upsilon -Pledge of the Year
AFPE Award: Procter & Gamble - AFPE Gateway To Research Fellowship

LING XU
University of Minnesota Twin Cities College of Pharmacy
Faculty Sponsor: James C. Cloyd, Pharm.D.
Faculty Sponsor Title: Professor, Experimental and Clinical Pharmacology
Major: Pharm.D.
GPA: 3.95/4.00
Expected Graduation: May 2010
Focus of Research: To demonstrate, in controlled clinical trials, the neuroprotective and antiseizure effects of topiramate in neonates with congenital heart disease undergoing heart surgery. Given that the number of newborns undergoing corrective heart surgery is 5-15,000 per year, intravenous topiramate is being developed as an orphan drug. The aim of the research is to determine the pharmacokinetics, pharmacodynamics, and safety of topiramate given intravenously to newborn rats and piglets. The project aims to develop an existing drug into an injectable formulation to treat hypoxic brain injury and seizures in newborns undergoing surgery.
Title of Research: “Use of Intraveneous Topiramate for Neuroprotection in Newborns Undergoing Heart Surgery.”
Degrees Received: B.S., Biochemistry, University of Minnesota, Twin Cities, May 2006
Honors Received: 2007, 2nd Place, CLARION Case Competition, Semi-finalist,OTC Case Competition; 2006, Peters Academic Scholarship, Dean’s List
AFPE Award: American Association of Pharmaceutical Scientists - AFPE Gateway To Research Scholarship

SHANNON L. ZANDY
University of Florida College of Pharmacy
Faculty Sponsor: Joanna Peris, Ph.D.
Faculty Sponsor Title: Associate Professor, Pharmacodynamics
Major: Pharm.D.
GPA: 3.41/4.00
Expected Graduation: May 2010
Focus of Research: To determine how intermittent high dose ethanol exposure affects ethanol responding in selfadministering rats and the neurochemical changes associated with that responding. The use of on-line capillary electrophoresis with laser-induced fluorescent detection (ce-lif) will be able to measure dopamine changes, as well as extend these findings to determine the relationship between the different neurotransmitter systems.
Title of Research:

“Neurochemical Changes Associated with Increased Motivation for Ethanol Self-Administration.”

Degrees Received: A.A., Pharmacy, University of Florida, May 2006
Honors Received: 2005, President’s List, National Society of Collegiate Scholars, Alpha Lambda Delta Honor Society; 2004, Highlands Regional Medical Center Health Scholarship
AFPE Award: Wyeth Pharmaceuticals - AFPE Gateway To Research Scholarship

STEPHANIE D. ZAUGG
Ohio Northern University College of Pharmacy
Faculty Sponsor: David H. Kinder, Ph.D.
Faculty Sponsor Title: Professor, Medicinal Chemistry
Major: Pharm.D., B.S., Biology, B.A., Spanish
GPA: 3.84/4.00
Expected Graduation: May 2008
Focus of Research: To use a novel 3D cell culture method to investigate the effect of hormones, in particular androgens and estrogens, on cancer cell growth in the presence of the COX-2 inhibitor celecoxib (Celebrex).
Title of Research: “Effect of Celecoxib on the Growth of HT-29 and MDA PCa 2b Prostate Carcinoma Cell Lines in the Presence of Androgens.”
Degrees Received: N/A
Honors Received: 2006, Rho Chi National Pharmacy Academic honorary; 2006, Omicron Delta Kappa National Leadership honorary; 2005 Phi Lambda Sigma National Pharmacy Leadership honorary; 2005, Beta Beta Beta National Biology honorary; 2005, Mortar Board National Leadership, Scholarship, and service honorary;
2004, Sigma Delta Pi National Spanish Honorary; 2004, Spanish Department Award; 2004, Resident Assistant of the Year 5 University Parkway/Northern House; 2003, Alpha Lambda Delta National Scholastic honor Society for 1st Year College Women
AFPE Award: United States Pharmacopeia (USP) - AFPE Gateway To Research Scholarship

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