Project
Description: |
Metastatic
melanoma is a difficult disease to treat and treatment options
are limited. Using a pharmacogenomic approach, our research previously
identified an association between the presence of a V600E BRAF
mutation in human melanoma cell lines and increased efficacy of
some phenothiazine compounds. Our research found that, in vitro,
other melanomas without the BRAF mutation, such as NRAS mutants
and BRAF/NRAS wild types, were not as sensitive to the anti-proliferative
pharmacologic effects of phenothiazines. In this study, we propose
to assess the in vivo efficacy of phenothiazines in mouse engrafts
of BRAF mutant human melanomas compared to NRAF mutant melanomas
and BRAF/NRAS wild type melanomas. |
