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2008-09 AFPE Minority Pre-Doctoral Fellow Profiles

COMFORT A. AGYEMANG
Florida Agricultural and Mechanical University College of Pharmacy and Pharmaceutical Sciences
Major Medicinal/Pharmaceutical Chemistry
GPA: 3.9/4.0
Graduation Date: August 2010
Focus of Research: To use the natural product cryptolepine as a lead scaffold to develop new agents as alternatives to Amphotericin B by introducing additional substituents into the ring system. This research strategy will enable me to investigate the possibility of increasing potency and decreasing cytotoxicity as compared to Amphotericin B, the current gold standard in antifungal drug development. Opportunistic infections, including fungus infections, are caused by pathogens that take advantage of a suppressed immune system. Conditions such as HIV AIDS disease, organ transplantation, and long-term use of corticosteroids, for example, cause either immune suppression or some disruption in the immune system. With an estimate of over 40 million people living with AIDS around the globe and the increasing development of resistance to current therapies, there is a continuing need for new, more effective, anti-infective agents against opportunistic infections.
Title of Dissertation: “Development of New Agents Against AIDS-Related Opportunistic Pathogens"
Degrees Received: B.S., Chemistry, University of Cape Coast (Ghana), June 2003
Honors Received: 2007 Alpha Kappa Mu Honors Society; 2005, Graduate Assistant in Areas of National Need
AFPE Award: Josiah Macy, Jr. Foundation - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences

DANIEL C. LANE
University of Michigan College of Pharmacy
Major Social & Administrative Sciences
GPA: 3.62/4.30
Graduation Date: August 2009
Focus of Research: To study the behavioral, biological, economic, and social influences effecting individual and group health related decision making, with a focus on the roles of emotion and motivation, and a particular interest in
populations with mental disorders. The research will employ a variety of mixed-methodological approaches
from a constructivist and participatory perspective. Interest in decision-science is increasing within the pharmaceutical sciences as the emphasis on translational research expands and the need to move innovation from bench to bedside relies on patient health related decision making.
Title of Dissertation: “Investigating the Role of Emotional Appraisals, Motives, and Values in Medication Related Decision Processes”
Degrees Received: Pharm. D., Pharmacy, Hampton University, May 2002
Honors Received: 2008, AACP/Wal-Mart Annual Conference Scholarship; 2008-2005, Horace H. Rackham Merit Fellowship; 2005, Who's Who of Empowering Professionals, Omnicare NWO Wonderful Individual Performance; 2003, CHRISTUS Jasper Memorial Hospital Patient Care Director of the Year & Team of the Year; 2002, Dean’s List; 2001, AstraZeneca Professional Scholarship; 2001, Dean’s List; 2000, Eckerd Scholarship Recipient, Perrigo Scholarship Recipient; 1999, Dean’s List; 1998-1996, Penfield Scholar; 1997-1996, Dean's List
AFPE Award: Josiah Macy, Jr. Foundation - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences

MARIBEL REYES
University of California at San Francisco School of Pharmacy
Major Pharmacokinetics/Metabolism
GPA: 3.4/4.0
Graduation Date: September 2010
Focus of Research: To investigate the effects of uremic toxins present in patients with chronic kidney disease on hepatic transporters and on metabolizing enzymes and, more specifically, to investigate the effects of uremic toxins on the pharmacokinetics of non-renally excreted Class I, II, & III drugs in cellular systems, in isolated perfused rat livers, and finally in vivo in healthy volunteers and patients with chronic kidney disease (DKD). It is hypothesized that the inhibition of hepatica transporters and/or metabolizing enzymes by uremic toxins may account for the observed decreases in the clearance and pharmacokinetics of different classes of drugs taken by patients with renal failure. This research can, ultimately, be useful in the dosing regimen of non-renally cleared drugs in patients with chronic renal failure.
Title of Dissertation: “Effects of Uremic Toxin on Hepatic Transporters and Metabolism: Changes in Pharmacokinetics of Class I, II, and III Drugs"
Degrees Received: B.S., Pharmacology, University of California, Santa Barbara, June 2002
Honors Received: 2004-2003, Fulbright Fellowship: 2002-1998, UCSB Chancellor’s Scholarship; 2001, NIH-Fogarty Minority International Research Training Program Fellowship; 1999, Hispanic Scholarship Fund.
AFPE Award: The Roche Foundation - AFPE Pre-Doctoral Fellowship in the Pharmaceutical Sciences