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2003-04 Pre-Doctoral Fellow Profiles

SPENCER ERICKSEN
West Virginia University College of Pharmacy
Major: Pharmaceutical Sciences
GPA: 4.00/4.00
Expected Graduation: May 2004
Focus of Research: This research will focus on structure-function relationships in cytochromes P450. Specifically, interests and investigations concern (1) the mechanism and regulation of electron transfer from P450 redox partner CPR to P450, and (2) molecular dynamics as it pertains to substrate specificity and oxidation mechanism in P450s.
Title of Dissertation: “Elucidation of the Interaction Between P450 1A1 and CPR by Modeling and Site-directed Mutagenesis and the Role of Enzyme-Substrate Interactions in P450 Substrate Oxidation.”
Degrees Received: M.S., Chemistry, Northern Michigan University, June 2001
B.S., Biochemistry, Northern Michigan University, May 1997
A.S., Physiology, Bay de Noc Community College, 1995
Honors Received: 2001, AFPE Pre-Doctoral Fellowship
AFPE Award 2001 Outstanding Graduating Graduate Student Award

TIA ESTEY
University of Colorado Health Sciences Center School of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.93/4.00
Expected Graduation: May 2005
Focus of Research: Currently, the administration of protein therapeutics is limited to injection, which requires painful daily injections for patients needing chronic treatment. Encapsulating proteins within a biodegradable polymer, such as poly(lactide-co-glycolide) (PLGA), can provide a continual release of protein for weeks to months. Controlled-release of therapeutic proteins is a desirable alternative to the current standard but has been limited due to the instability of proteins within such systems. The primary focus of this research project is to develop a stable, controlled-release protein delivery system.
Title of Dissertation: “Increasing Protein Stability within PLGA Delivery Systems.”
Degrees Received: B.S., Biological Sciences, University of Denver, June 1999
Honors Received: 2003, Nominated for UCHSC Ethics Committee, Student Representative; 2002, NIH Leadership Training Fellowship Grant Renewal,; 2001, NIH Leadership Training in Pharmaceutical Biotechnology Fellow; 2001, 1st Place Student Podium Presentation, UCHSC Annual Research; 2001, 1st Place Student Podium Presentation, MWSOT Annual Meeting; 1998, PINS Research Grant, University of Denver; 1998, Pustmueller Undergraduate Research Fellow; 1995, Honors Program and Scholarship, University of Denver
AFPE Award  

JOEL FARLEY
University of Wisconsin-Madison School of Pharmacy
Major: Social & Administrative Sciences
GPA: 3.94/4.00
Expected Graduation: May 2005
Focus of Research: My research focus is pharmaceutical and health economics. I am particularly interested in outcomes research, pharmaceutical pricing, and pharmaceutical policy. Other interests include insurance demand theory and epidemiology.
Title of Dissertation: “The Moral Hazard of Including Prescription Drug Benefits in Traditional Health Insurance”
Degrees Received: B.S., Pharmacy, University of Wisconsin, May 1997
Honors Received: 1997-95, Pharmacy School Honor Roll
AFPE Award  

DAVID J. FEOLA
University of Kentucky College of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.43/4.00
Expected Graduation: May 2004
Focus of Research: This project focuses on investigating a question of synergistic drug toxicity combines the disciplines of immunology, toxicology, and infectious diseases pharmacology. The final stage of the project will involve a translational component to investigate it clinical significance.
Title of Dissertation: “Combination of Sulfamethoxazole/trimethoprim and Zidovudine: Investigation of Synergistic Bone Marrow Toxicity in Mice."
Degrees Received: Pharm.D., University of Kentucky College of Pharmacy, May 1997
B.S. Pharmacy, University of Kentucky College Of Pharmacy, December 1996
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2001, BCPS Certification; 2001, UKMC Outstanding Pharm. Resident Award; 2000, UKMC Residency Program Impact Award; 1997-1995, UKCOP Dean EP Sloan Leadership Award; 1997, UKCOP Outstanding Graduating Man Award; 1995, UKCOP Kappa Psi Graduate Chapter Award
AFPE Award ACPE-AFPE Association Fellowship in the Pharmaceutical Sciences

MATTHEW FIDLER
University of Utah College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 3.74/4.00
Expected Graduation: May 2005
Focus of Research: Pharmacodynamics-Multiple drug interaction modeling. The following hypotheses are of interest: (1) Create a model that fits and is more flexible in modeling interactions that previous models, (2) the model can be extended to make statistical statements over a broad rage of effects, and (3) the model appropriately fits many types of Pharmacodynamic data.
Title of Dissertation: “Multiple Drug Interactions: A Flexible Approach.”
Degrees Received: B.S., Math and Chemistry, Westminster College, May 1999
Honors Received: 2003 Who’s Who in American Colleges/Universities; 2002-01, Kuromoto Fellow; 2001-00, Higuchi Fellow; 1999, Outstanding Graduate in Mathematics
AFPE Award  

BRENT FOX
Auburn University School of Pharmacy
Major: Social and Administrative Sciences
GPA: 4.0
Expected Graduation: August 2004
Focus of Research: The focus of this research is to apply the Technology Acceptance Model (TAM) to pharmacists use of personal digital assistants (PDAs) as clinical resources when performing patient interventions. The research will identify factors influencing PDA use. The research will compare the PDA to other resources in terms of benefit to practice and impact on patient care.
Title of Dissertation: “Explaining Pharmacists’ Use of Personal Digital Assistants as Clinical Resources During Patient Care Interventions.”
Degrees Received: Pharm.D., Pharmacy, Auburn University, June 1999
B.S., Pharmacy, Auburn University, June 1998
Honors Received: 2003, Auburn University Graduate Council Humanities/Social Sciences 2nd Place Poster; 2002-01, Tillery Pharmacy Fellowship; 1998, Roche Pharmacy Communications Award; 1994-92, Honors Program, University of Mississippi
AFPE Award  

JOHN R. GOODELL
University of Minnesota College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 3.81/4.00
Expected Graduation: August 2004
Focus of Research: To design and synthesize unique opioid ligands originating from structure of SNC 80. Such structures as indoles, imidazoles and benzimidazoles will serve as base scaffolds in which to develop novel series of compounds.
Title of Dissertation: “Structure Based Design of Novel Opioid Ligands.”
Degrees Received: B.S., ACS-Chemistry-Biochemistry, University of Wisconsin-River Falls, June 2000
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2000-1998, Dean’s List
AFPE Award ABE PLOUGH Memorial Fellowship in Pharmaceutical Chemistry

SANDRA L. GOSS
University of Connecticut School of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.90/4.00
Expected Graduation: January 2005
Focus of Research: A novel physicochemical hypothesis will be tested to explain the low and variable absorption of calcium supplements fro the gastrointestinal tract, through both invitro dissolutions and human clinical study.
Title of Dissertation: “The Role of Gastric pH and Bicarbonate Secretion in Calcium Absorption.”
Degrees Received: B.S., Pharmaceutical Science, University of Mississippi, May 1997
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2002, USP Graduate Fellowship; 2001, Boehringer-Inglheim Summer Internship; 1999, SmithKline Beecham Silver Award; 1997, Rho Chi Certificate of Recognition; 1997, Phi Delta Chi Academic Excellence Award; 1996, Pfizer Summer Fellowship
AFPE Award AFPE Fellowship in the Pharmaceutical Sciences

LAURA L. GROCHOWSKI
Oregon State University College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 3.72/4.00
Expected Graduation: March 2004
Focus of Research: The focus of this research is to study natural product biosynthesis at the genetic and enzymatic levels. The investigation of two biosynthetic pathways is being undertake. The aim of the first project is to clone and express natural product biosynthetic gene clusters from a marine sponge. A mixed biosynthetic gene cluster has bee cloned and sequenced from the genomic DNA of a marine sponge. The characterization of this pathway is currently involved in the biosynthesis of blasticidin S, including an arginine aminomutase, a ribosyltransferase, and a putative nucleotide hydrolase.
Title of Dissertation: “Molecular Genetic and Enzymatic Characterization of Natural Product Biosynthysis”
Degrees Received: B.S., Biology, Delaware College of Science and Agriculture, June 1997
Honors Received: 2003, Sponenburgh Travel Award; 2003 OSU COP Award for Podium Presentation; 2002, OSU COP Award for Poster Presentation; 1996, Undergraduate Award in Analytical Chemistry; 1997-1993, Dean’s List; 1995, National Dean’s List
AFPE Award ALBERT B. FISHER Citation Fellowship in the Pharmaceutical Sciences

HOVHANNES J. GUKASYAN
University of Southern California School of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.80/4.00
Expected Graduation: May 2004
Focus of Research: Study the basic physiology of the ocular surface and human tears in health and disease. This identifies biomarkers and potential drug targets. Specifically, I made a breakthrough in characterizing the important and beneficial role of speicifc antioxidants on the surface of the eye.
Title of Dissertation: “Oxidation Induced Changes in Ocular Surface Physiology: Implications In Drug Delivery in Targeting in Health & Diseases.”
Degrees Received: B.S., Chemistry, University of Southern California
Academic Minor, Biological Sciences, University of Southern California, May 1999
Honors Received: 2002, Rho Chi Pharmacy Honor Society; 2001, Outstanding Graduate Student Leader; 2001-1998, Town & Gown of USC Scholarship; 1999, PhRMA Undergraduate Fellowship; 1998, USC Chemistry Alumni Award; 1996-1995, Dean’s List; 1996, Alpha Lambda Delta (Academic Honors)
AFPE Award DONALD AND FRANCES BRODIE Fellowship in the Pharmaceutical Sciences

MATTHEW K. HADDEN
Medical University of South Carolina College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 3.96/4.00
Expected Graduation: December 2004
Focus of Research: To improve the pharmacokinetic properties of neurotensin, a centrally active peptide. The incorporation of non-natural analogues of arginine and lysine into Neurotensin which will create novel analogues with therapeutic potential.
Title of Dissertation: “Neurotensin Analogues: Potential for Therapeutic Compounds.”
Degrees Received: B.S., Chemistry, Wofford College, May 2000
Honors Received: 2003-2002, AFPE Pre-Doctoral Fellowship; 2002, Rho Chi Pharmacy Honor Society; 2000, MUSC COGS Dean’s Fellowship; 1996, Palmetto Fellow
AFPE Award CHARLES R. WALGREEN Memorial Fellowship in the Pharmaceutical Sciences

ERIN L. HEINZEN
University of North Carolina at Chapel Hill School of Pharmacy
Major: Pharmacokinetics/Pharmacodynamics
GPA: N/A
Expected Graduation: May 2004
Focus of Research: To investigate the role of nitric oxide on the development of morphine antinociceptive tolerance as it pertains to morphine pharmacodynamics, mu-opioid receptor pharmacology, and pharmacokinetic disposition.
Title of Dissertation: “The Role of Nitric Oxide as a Mediator of Morphine Antinociceptive Tolerance.”
Degrees Received: Pharm.D., University of North Carolina, August 2001
Honors Received: 2000, Miya Endowment Scholarship Recipient; 1999, George T. Cornwell Scholar Recipient; 1995, Moran Scholarship Recipient
AFPE Award AFPE 21st CENTURY CLUB Fellowship in the Pharmaceutical Sciences

JEFFREY N. HEMENWAY
University of Kansas School of Pharmacy
Major: Pharmaceutics
GPA: 3.89/4.00
Expected Graduation: June 2004
Focus of Research: The focus of this research is to develop new water-soluble pro-drugs of Carbamazepine and oxcarbamazepine that are suitable for parenteral and oral delivery, and to determine the feasibility using this acyl-urea pro-drug approach to enhance the delivery characteristics of poorly water-soluble drugs.
Title of Dissertation: “Preparation, Physicochemical Properties, and Animal Studies of New Acyl-Urea Pro-Drugs of Carbamazepine and Oxcarbazepines.”
Degrees Received: M.S., Pharmaceutics, University of Kansas, January 2002
B.S., Chemistry, University of Missouri Kansas City, December 1997
A.A., Arts, Longview Community College, June 1994
Honors Received: 2003-00, Perdue Pharm Tuition Fellowship; 2002, AFPE Pre-Doctoral Fellowship; 1999, Frank B. Dains Award; 1999, H.P. Cady Award; 1997-1995, Departmental Honors; 1997-1995, Dean’s List
AFPE Award MERCK-AFPE Fellowship in Pharmaceutics

MATTHEW HRUSKA
University of Pittsburgh School of Pharmacy
Major: Pharmacokinetics/Metabolism
GPA: 3.76
Expected Graduation: December 2004
Focus of Research: The focus of my research is to investigate the impact genotype has on pharmacokinetics and drug metabolism. Primarily my research focuses on the polymorphic expression of CYP2C8 and how it influences rosiglitazone metabolism in vivo and in vitro. My research will characterize the metabolic profile of rosiglitazone as it is affected by CYP2C8 polymorphic expression.
Title of Dissertation: “Pharmacogenomics of CYP2C8 Activity: Implications on Drug Therapy.”
Degrees Received: Pharm.D., Pharmacy, University of Pittsburgh, April 2000
Honors Received: 2000, Pfizer Outstanding Leader Award, 2000, ASP Student of the Year, 2000, Phar-Mor Inc. Scholarship, 1999, Community Value Stores Scholarship, 1999, Ralph R. Kartub “Mr. Ralph” Memorial Scholarship
AFPE Award  

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Profile of Current Winners: A-C, D-I, J-L, M-P, Q-Z
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