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2003-04 Pre-Doctoral Fellow Profiles

RANYIA MATTA
Ohio State University College of Pharmacy
Major: Pharmaceutics
GPA: 3.77
Expected Graduation: June 2006
Focus of Research: My research focuses on developing telomere and telomerase as cancer therapeutic agents. Telomere is the structure at the end of DNA that is responsible for maintaining chromosome integrity. Telomere is shortened with each cell replication thus contributing to aging and mortality. Telomerase is the only known enzyme that elongates telomere. My hypothesis is to test whether combining a DNA/telomere-damaging chemotherapeutic agent with a telomerase inhibitor yields synergistic antitumor activity. My goal is to translate the preclinical findings for clinical use
Title of Dissertation: “Telomere/Telomerase Targeted Cancer Therapy.”
Degrees Received: B.S., Pharmacy, Ohio State University, June 2001
Honors Received: 2001, Pharmacognosy Award; 2001, magna cum laude, Ohio State University; 2001, President’s Salute to Undergraduate Achievement award, 1999, My biography was published in the National Dean’s list annual publication; 1999, Plough Pharmacy Scholarship; 1998, Campus Scholarship; 1998, Dean’s Honor roll
AFPE Award  

JENNIFER S. McCULLAR
Oregon State University College of Pharmacy
Major: Molecular and Cellular Biology
GPA: 3.83/4.00
Expected Graduation: June 2004
Focus of Research: We have identified Calmodulin (CaM) as a Phospholipase C-beta (PLCb) interacting protein. Currently, my research focuses on characterizing the nature of the PLCb/CaM interaction and identifying differential interactions of CaM between the PLCb and PLCb-3 isozymes.
Title of Dissertation: “Novel Regulation of Phospholipase C-beta By Calmodulin.”
Degrees Received: M.S., Animal Science, Oregon State University, June 1998
B.S., Animal Science and Zoology, Oregon State University, June 1995
Honors Received: 2002, College of Pharmacy Poster Award; 2002, Rho Chi Pharmacy Honor Society; 2002, ASPET; 2001-2000, NSF GK-12 Fellowship; 2000-1998, Eckelman Dairy Research Fellowship; 1998-1996, Eckelman Dairy Research Fellowship; 1995, Association for Women in Science
AFPE Award AFPE Fellowship in the Pharmaceutical Sciences

MARY P. McRAE
University of North Carolina – Chapel Hill School of Pharmacy
Major: Pharmaceutical Sciences
GPA: N/A
Expected Graduation: June 2004
Focus of Research: My research focuses on the hepatoxicity of antiretroviral therapy. Specifically, I am interested in determining the mechanisms behind the development of cholestasis with respect to the expression and activity of hepatic bile acid transporters.
Title of Dissertation: “Understanding the Hepatotoxicity of Antiretroviral Drugs Used in the Treatment of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS).”
Degrees Received: Pharm.D, Virginia Commonwealth University/MCV, May 2000
B.S., Health and Sports Science, Wake Forest University, May 1992
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2000, Dean’s Award (VCU/MCV); 2000, Clinical Research Award; 2000, Phi Lambda Sigma Pharmacy Honor Society; 2000, Rho Chi Pharmacy Honor Society; 1999, ASHP Clinical Skills Top 10; 1999, E.E. Willey Scholarship; 1998, Warren E. Weaver Scholarship; 1997, VCU School of Pharmacy Scholar; 1997, Rho Chi Student Achievement
AFPE Award USP-AFPE Association Fellowship in the Pharmaceutical Sciences

KRISTIN L. MEAGHER
University of Michigan College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 8.37/9.00
Expected Graduation: June 2005
Focus of Research: My research uses multiple protein structures (MPS) obtained from molecular dynamics simulations to create Pharmacophore models of HIV-1 protease. These models will be sued to screen databases of known HIV-1 protease inhibitors and inactive drug-like molecules. By including protein flexibility in our models, we expect to more accurately predict the activity of known ligands compared to simple static models of HIV-1 protease. An additional goal of this project is to examine the different variables of the MPS method and to elucidate the most general and universal protocol for this kind of situation.
Title of Dissertation: “The Development of Receptor Based Pharmacophore Models of HIV-1 Protease Using Multiple Protein Structures.”
Degrees Received: B.A., Chemistry, Princeton University, June 1997
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2000, Regents Fellowship-University of Michigan
AFPE Award AFPE Fellowship in Medicinal/Pharmaceutical Chemistry

SUJATHA S. MENON
University of Michigan College of Pharmacy
Major: Pharmaceutical Sciences
GPA: 8.05/9.00
Expected Graduation: October 2003
Focus of Research: To develop approaches that describe and predict time-dependent oral drug absorption in humans.
Title of Dissertation: “Time-Dependent Oral Drug Absorption in the GI Tract.”
Degrees Received: M.S., Pharmacy/Pharmaceutics, University of Texas at Austin, 1993
M. Pharmacy, Pharmacy, University of Bombay, India, 1988
B. Pharmacy, Pharmacy, University of Madras, India, 1986
Honors Received: 2002, AAPS, American Association of Indian Pharmacy Scientists Award; 1986, Nageswara Roa Gold Medal; 1986, G.P. Nair Award; 1986, Rajagopal Award
AFPE Award NOVARTIS-AFPE Fellowship in Pharmaceutics

TIMOTHY C. MEREDITH
University of Michigan College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 8.17/9.00
Expected Graduation: September 2005
Focus of Research: The enzyme Arabinose 5 phosphate Isomerase (API) catalyzes the first step in the biosynthesis of 3-deoxy 8 manno-octulosonic acid (KDO). KDO is a required component of the lipopolysaccharide (LPS) layer of Gram Negative bacteria. The focus of the research is to study recombinant API in order to determine the mechanism and to then ultimately design and synthesis inhibitors. These compounds will then be evaluated for antibiotic potential.
Title of Dissertation: “Arabinose-5-Phosphate (A5P) Isomerase: Mechanistic and Inhibition Studies.”
Degrees Received: B.S., Chemistry, Villanova University, May 2000
Honors Received: 2002-2001, Chemical Biological Interface (CBI) Training Grant Recipient; 2000, College of LSA Medallion Recipient for Academic Excellence in Chemistry; 1997, CRC Press LLC Freshman Chemistry Achievement Award; 2000-1996, Dean’s List
AFPE Award PFIZER-AFPE Fellowship in Medicinal/Pharmaceutical Chemistry

JOANNA L. MICHEL
University of Illinois at Chicago College of Pharmacy
Major: Pharmacognosy
GPA: 4.83/5.00
Expected Graduation: April 2005
Focus of Research: The application of pharmacognostic, ethnobotanical, and taxonomic techniques to explore the safety, efficacy, and toxicity of plant based remedies used by the Q’eqchi Maya of the Lowland tropical rain forest in Guatemala. As requested by the Q’eqchi, emphasis will be placed on the evaluation of plants used against fungal infections, resulting in leads for the development of antimycotic phytomedicines and/or pharmaceuticals.
Title of Dissertation: “Medical Botany and Antifungal Remedies of the Q’eqchi Maya of Guatemala.”
Degrees Received: Certificate in Ecological Horticulture, Organic Farming and Gardening, The University of Santa Cruz, October 1997
B.A., Spanish Language and Literature & Pre Med, Tulane University, May 1994 (Cum Laude)
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 1994, Phi Beta Kappa Honor Society; 1994, Premio Clavilcno
AFPE Award SILAS M. BURROUGHS Memorial Fellowship in the Pharmaceutical Sciences

JUDITH A. MLOCKIER-AUDRAIN
St. John’s University College of Pharmacy and Allied Health Professions
Major: Pharmacology/Toxicology
GPA: 3.55/4.00
Expected Graduation: May 2004
Focus of Research: The effects of diethyldithiocarbamate on rat hippocampal astrocytes in terms of programmed cell death and preventing it by pretreating with glutathione. Apoptosis has been shown to induce irreversible cell injury. This may offer important information concerning the mechanism of toxicity of the thiocarbamates.
Title of Dissertation: “Effects of Diethyldithiocarbamate (DDC) and Glutathione (GSH) on Apoptosis on Hippocampal Astrocytes.”
Degrees Received: M.S., Pharmacology, St. John’s University, January 1998
B.A. Chemistry, Queens College CUNY, September 1991
French Bac., Literature/Math, Lycee Francais de NY, June 1986
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2002, SOT Travel Award; 1995, Rho Chi Pharmacy Honor Society; 1990, Beta Delta Chi; 1990, Pi Delta Phi
AFPE Award PhRMA-AFPE Association Fellowship in Pharmacology/Toxicology

YONG-HSIN NG
University of Southern California College of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.84/4.00
Expected Graduation: December 2004
Focus of Research: Cytochrome P450 (CYP) eicosanoids are potent vasoactive and anti-inflammatory compounds that are significant players in cardiovascular disease. Though the CYP eicosanoids exert their effects in the vasculature, the regulation of their formation has only been characterized in the liver and kidney, not at their site of action. The focus of my research is to investigate the regulation of CYP eicosanoids formation by the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARa) in the vasculature.
Title of Dissertation: “Regulation of Cytochrome P450 Eicosanoid Levels by Peroxisome Proliferator-Activated Receptor Alpha in the Vasculature.”
Degrees Received: B.A., Molecular and Cell Biology, University of California at Berkley, May 1999
B.A., French, University of California at Berkley, May 1999
Honors Received: 2003, NIH NIDDK Travel Award for Keystone Symposia “PPARs”; 2002, PhRMA Foundation Predoctoral Fellowship; 1999, UC Berkeley BA with Honors; 1998, UC Berkeley Paul Brun Scholar; 1997, UC Berkeley Dean’s List; 1999-1994, UC Berkeley Honors Status
AFPE Award  

TAN NGUYEN
University of California at San Francisco School of Pharmacy
Major: Pharmaceutical Sciences and Pharmacogenomics
GPA: 3.78/4.00
Expected Graduation: December 2004
Focus of Research: MRP2 is able to transport a wide variety of anionic compounds, some of which are anti-cancer drugs, for elimination. Variations in the protein can alter the function of the transporter and therefore alter how these drugs are eliminated from the body. The focus of my research is to identify and functionally characterize genetic variations in MRP2, and determine whether they alter the protein’s ability to transport substrate drugs.
Title of Dissertation: “Genetic and Functional Analysis of Multidrug Resistance-Associated Protein 2 (MPRs) Polymorphisms.”
Degrees Received: B.S., Biology, University of California-Irvine, June 1997
B.S., Chemistry, University of California-Irvine, June 1997
Honors Received: 2001-00, UCSF Graduate Student Mentorship and Assistantship Program; 1999, Graduate Opportunity Fellowship, 1993, UC Regents Scholarship
AFPE Award  

THERESA V. NGUYEN
University of Michigan College of Pharmacy
Major: Pharmaceutics
GPA: 7.46/8.00
Expected Graduation: April 2005
Focus of Research: The high renal clearance of many gabapentinoids limits their clinical utility. To understand the disposition of these compounds in the kidney, this project will focus on establishing renal epithelial cell lines for studying the roles of various transporters in the absorption, distribution, and elimination of gabapentinoids as a function of their chemical structure. Eventually, this project will progress on to mechanistic studies in transfected cell lines for specific transporters.
Title of Dissertation: “The Characterization of Gabapentinoids and Pregablin Transport in Epithelial Cell Lines.”
Degrees Received: Pharm.D., Howard University, April 2000
B.S., Biology, University of California-Los Angeles, June 1996
Honors Received: 2003-01, NIH Pharmacological Science Training Program; 2002, AFPE Pre-Doctoral Fellowship; 2001, Fred and Dee Lyons Fellowship; 2000, Warner-Lambert/Parke-Davis Fellowship; 2000, Pfizer U.S. Pharmaceuticals Outstanding Leader; 1998, Rho Chi Pharmacy Honor Society; 2000-1997, HU School of Pharmacy Trustee Scholarship; 1997, HU APhA Patient Counseling Competition; 2000-1996, HU School of Pharmacy Dean’s Honor Roll; 1996, HU Resident Hall Academic Award
AFPE Award NOVARTIS-AFPE Fellowship in Pharmaceutics

SCOTT M. OCHELTREE
University of Michigan College of Pharmacy
Major: Pharmaceutical Sciences
GPA: 8.63/9.00
Expected Graduation: May 2005
Focus of Research: The focus of this research is defining the chemical, pharmacological and pharmacokinetic implications that result from the direct interactions of substrates with peptide transporters located in the choroids plexus epithelium and retinal pigment epithelium. I will also focus on the effect that PEPT2 has upon the in vivo disposition kinetics and organ distribution of a synthetic, hydrolysis/peptidase resistant, model dipeptide and an enzymatically stable peptide-like drug, after systemic administration in PEPT2-transgenic knockout mice.
Title of Dissertation: “The Role of Peptide Transporters in Multiple Organ Systems: Implications for the Systemic and Regional Dispostion of Peptides/Mimetics.”
Degrees Received: Pharm.D, University of Iowa College of Pharmacy, May 2000 (Honors and Highest Distinction)
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2001, Fred W. Lyons, Jr. Fellowship; 2000, College of Pharmacy Faculty Award; 2000, Collegiate Scholar Award; 2000, Golden Key National Honor Society; 1999, Rhodes Dunlap Scholarship Winner; 1999, Pharmacy Tuition Scholarship; 1998, Rho Chi Pharmacy Honor Society; 1998, Honor’s Program at the University of Iowa; 1997, Pharmacists Mutual Award
AFPE Award PHARMACEUTICAL ADVERTISING INDUSTRY-AFPE Fellowship in the Pharmaceutical Sciences

JIGNA PATEL
University of Kentucky College of Pharmacy
Major: Pharmaceutics
GPA: 3.79/4.00
Expected Graduation: May 2005
Focus of Research: To investigate the use of novel nanoparticles engineered from microemulsion templates for targeted delivery of HIV-1 proteins, gag and tat, to elicit enhanced as well as balanced immune responses compared to standard adjuvanted protein.
Title of Dissertation: “Nanoengineered HIV-1 Vaccines Based Gag and Tat.”
Degrees Received: M.S., Chemistry, University of Kentucky, May 1999
B.S., Chemistry, University of Kentucky, May 1998
Honors Received: 1998, 3rd Place in Poster Competition at the American Institute of Chemical Engeers Convention; 1996, 1st Place, Regional Undergraduate Chemistry Research Poster; 1996, Golden Key National Honor Society; 1996-94, Deans Honor List
AFPE Award  

MITCHELL PHELPS
Ohio State University College of Pharmacy
Major: Pharmaceutics
GPA: 3.68/4.00
Expected Graduation: June 2005
Focus of Research: My research investigates the uptake efficiency of riboflavin binding protein (RBP) and riboflavin in breast tissue to determine the viability of RBP for use in tumor imaging and drug targeting in breast cancer. RBP delivers the essential vitamin, riboflavin, to the developing fetus during pregnancy, and it is believed to serve a similar function in tumor growth and development. RBP is upregulated in tumor tissue and in serum in breast cancer patients, which poses an untapped possibility for targeted delivery of imaging or therapeutic agents via conjugation to RBP or riboflavin.
Title of Dissertation: “Targeted Delivery of Imaging and Therapeutic Agents to Breast Tumors Through Riboflavin-Mediated Transport.”
Degrees Received: MLHR, Business Management – Human Resources, Ohio State University, June 1999
B.S. Physics, Ohio Wesleyan University, May 1992
Honors Received: 2002, Council of Graduate Students Research Travel Grant Recipient; 2001, Hazel Brown Teaching Award, Department of Physics; 2000-99, Dean’s List; 1992, Psi Chi National Honor Society
AFPE Award  

QUENTIN HOA L. PHUNG
University of Oklahoma College of Pharmacy
Major: Social & Administrative Sciences (Marketing)
GPA: 3.88/4.00
Expected Graduation: May 2004
Focus of Research: My focus of research is to analyze consumers’ perception of pharmacy and their needs for pharmaceutical care services. My objective in this are is to re-focus consumers’ perception of pharmacy to that of a service oriented industry. I play to study how pharmacist can better market themselves to all stakeholders as an integral healthcare service provider.
Title of Dissertation: “Assessing Patients’ Needs And Their Intention For Using Pharmaceutical Care Services.”
Degrees Received: B.S., Pharmacy, University of Oklahoma, May 1999
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2001, E. Blache Sommers Award; 1999, Lilly Achievement Award; 1999, Roche Pharmacy Communication Award; 1999, Merck Outstanding Research and Scholastic Excellence Award; 1999, ASHP’s Counseling Contest Winner; 1998, Stanford Scholarship Recipient; 1997, Rho Chi Outstanding Academic Award; 1994, Honors Scholarship Recipient
AFPE Award NACDS-AFPE Association Fellowship in Social & Administrative Sciences

KAREN PICA
Philadelphia College of Pharmacy University of the Sciences in Philadelphia
Major: Pharmaceutics
GPA: 3.93/4.00
Expected Graduation: August 2004
Focus of Research: Our goal is to make a prolonged release drug delivery system for gelatin-methotrexate fragments by crosslinking macromolecular conjugates into microspher for injection into the tumor providing added benefits to macromolecular drug conjugate systems.
Title of Dissertation: “The Effect of Drug Load to Extend MTX Release from Gelatin-Methorrexate Conjugated Microspheres.”
Degrees Received: B.S., B.A., Chemical Engineering/College Major, Bucknell University, May 1999
Honors Received: 2003, Chuck Stevens Memorial Research Poster Award; 2002, Elof F. Johnson Research Award (USIP, Dept. Pharmaceutical Science)
AFPE Award  

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