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2003-04 Pre-Doctoral Fellow Profiles

KATHLEEN I. SEYB
University of Kansas School of Pharmacy
Major: Pharmacology/Toxicology
GPA: 3.75/4.00
Expected Graduation: May 2005
Focus of Research: Microtubule destabilization and a loss of calcium homeostasis has been observed in Alzheimer’s Disease. This research is focused on the effect of microtuble stabilizing agents on maintaining intracellular calcium homeostasis and preventing cell death.
Title of Dissertation: “Microtubule Stabilization Protects Against Beta-Amyloid Neurotoxicity by Maintaining the Proximity of Cellular Structures and Molecules Involved in Endoplasmic Reticulum Calcium Regulation.”
Degrees Received: B.S., Chemistry, University of Memphis, August 2000
Honors Received: 2000-Present, Bishop Graduate Scholarship; 2000, Chi Beta Phi Award for Excellence in Chemistry; 2000-1996, Cecil B. Humphrey Presidential Scholarship
AFPE Award NWDA-AFPE Association Fellowship in the Pharmaceutical Sciences

JAMES SHAW
University of Arizona College of Pharmacy
Major: Pharmaceutical Sciences
GPA: 3.89/4.00
Expected Graduation: May 2004
Focus of Research: Much of my research has focused on quality of life, health economics, and consumer behavior. In particular, measuring the impact of pharmaceutical consumption on economic and humanistic outcomes. More recently, my focus has turned toward the measurement of population health state preferences using tools such as the Health Utilities Index and the EuroQol Group’s EQ-5D.
Title of Dissertation: “Development of US Population-Based Preferences for the EQ-5D Health States.”
Degrees Received: M.S. Pharmaceutical Sciences University of Arizona, May 2000
Pharm.D. Pharmacy Philadelphia College of Pharmacy and Science, May 1998
B.S. Pharmacy Philadelphia College of Pharmacy and Science, May 1997
B.S. Biology, Chemistry Beaver College, May 1993
Honors Received: 2003, American Marketing Association Steinberg Marketing Education Scholarship; 2002, Medical Care Section Student Paper Award Session, American Public Health Association, 130th Annual Meeting and Exposition; 2000, Best Overall Student Contribution Award, International Society for Pharmacoeconomics and Outcomes Research, 5th Annual International Meeting; 2000, Best Contributed Paper Award, International Society for Pharmacoeconomics and Outcomes Research, 5th Annual International Meeting; 2000, Distinguished Service Award, American Chinese Pharmaceutical Association; 1999, New Investigator’s Award, Society for Research on Nicotine and Tobacco, 5th Annual Meeting; 1999-98, Yuma Friends of Arizona Young Investigator Research Award; 1998, Pharmacists Mutual Companies Award; 1997, Parke-Davis Commitment to Excellence Scholarship Award; 1998-95, Dean’s List; 1997, Rho Chi Pharmacy Fraternity; 1996, Rho Pi Phi Pharmacy Fraternity
AFPE Award  

STACY SMEAL
University of Utah College of Pharmacy
Major: Pharmacology/Toxicology
GPA: 3.82/4.00
Expected Graduation: July 2004
Focus of Research: Analysis of hair for drugs of abuse has increasingly been used as an alternative to traditional urinalysis. Hair is a complex protein matrix capable of many types of interactions with drugs. Certain drugs have been shown to be preferentially incorporated into hair by pigmentation. The binding of basic drugs, like cocaine, on melanin is believed to produce a hair color effect through both ionic and non-ionic interactions. However, our present knowledge regarding the characteristics and mechanisms for the incorporation of non-basic drugs or their metabolites remains incomplete. Using delta-9-tetrahydrocannabinol, the active component of marijuana, we will study the mechanism of non-basic drugs of abuse into hair.
Title of Dissertation: “Mechanism of Cannabinoid Incorporation in Hair.”
Degrees Received: B.S., Biology, University of Texas at Austin, May 1999
Honors Received:  
AFPE Award  

JARED T. SPLETSTOSER
University of Kansas School of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 3.74/4.00
Expected Graduation: August 2004
Focus of Research: The manipulation of taxoid chemotherapeutics to permeate the blood-brain barrier. Specifically, to reduce the affinity of Taxol analogs toward the p-glycoprotein efflux system. Additionally, the use of azide-base photoaffinity labels to effectively probe the Taxol/tubulin interaction site.
Title of Dissertation: “I. The Development of Novel Taxoids with Reduced Affinity Towards P-Glycoprotein for Delivery to the Brain II. Photoaffinity Taxoids to Probe the Tubulin Binding Site.”
Degrees Received: M.S., Medicinal Chemistry, University of Kansas, 2002
B.S., Cytotechnology, University of North Dakota, August 1999
Honors Received: 2002, Groetsch Pre-Doctoral Fellow; 2000, Dept. of Defense Breast Cancer Fellow; 1999, NASA-JSC Micro-Gravity Research Participant; 1999-1994, BNI Coal Scholarship; 1998, National Dean’s List; 1997 Honor Marshal-University of North Dakota; 1997, UND Athletic Director Academic Achievement Award; 1996, Thomas D. Campbell Scholarship; 1995, Maxwell Upson Scholarship; 1997/1994, UND Dean’s List
AFPE Award AFPE Fellowship in Medicinal/Pharmaceutical Chemistry

BARBARA R. SPONG
University of Michigan College of Pharmacy
Major: Pharmaceutics
GPA: 7.03/9.00
Expected Graduation: December 2004
Focus of Research: The aim of this research is to enhance the pharmaceutical behavior of poorly soluble drugs by preparing new phases and to study the mechanism by which such drug properties are improved. Two approaches have been taken in preparing these phases. The first is through the preparation of crystals of carbamazepine with various excipeints. The second involves the formatin of a new mesophase of Ritonavir in aqueous solutions and under physiological conditions. The overall objective will focus on undrstanding the crystallization and dissolution mechanisms of the new phases and how they relate to intermolecular interactions in solution and in the solid-state.
Title of Dissertation: “Molecular Level Events Governing the Crystallization and Dissolution of New Phases of Carbamazepine and Ritonavir.”
Degrees Received: M.S., Pharmaceutical Sciences, University of Michigan, April 2001
B.S., Pharmacy, Rutgers University-College of Pharmacy, May 1998
Honors Received: 2003-2000, AFPE Fellowship; 2001-2000, AFPE Pre-Doctoral Fellowship; 2001, USP Fellowship; 2002-2000, Fred W. Lyons, Jr. Fellowship; 1998, GEM Ph.D. Science Fellowship; 1998-1995, Merck Manufacturing Division Minority Engineering Fellowship
AFPE Award GLAXOSMITHKLINE-AFPE Fellowship in Manufacturing/Industrial Pharmacy

TONY TALDONE
St. John’s University College of Pharmacy and Allied Health Professions
Major: Medicinal/Pharmaceutical Chemistry
GPA: 3.68/4.00
Expected Graduation: June 2006
Focus of Research: ?-Lactams represent a class of compounds whose medicinal properties have heretofore been neglected. My research will be devoted to the synthesis of a-lactams and an evaluation of their potential as new antibiotic agents. The structural similarity to the ß-lactam ring common to the penicillin makes these compounds an attractive target.
Title of Dissertation: “a-Lactam (Aziridinone) Antibiotics: The Synthesis, Antibiotic Activity, and Mechanism of Action of New a-Lactam Antibiotics.”
Degrees Received: M.S., Chemistry, St. John’s University, June 2000
B.S., Chemistry, St. John’s University, June 1999
Honors Received: 1999, Gold Key; 1998, Silver Key; 1999 & 1996, All-American Scholar Collegiate Award; 1999-95, Dean’s List; 1995, Scholastic Excellence Scholarship
AFPE Award  

MICHAEL D. TAYLOR
University of Florida College of Pharmacy
Major: Social & Administrative Pharmacy (Pharmacy Health Care Administration)
GPA: 3.95/4.00
Expected Graduation: May 2004
Focus of Research: My research focuses is outcomes research with an emphasis in the area of pharmacoeconomics. More specifically, I am interested in the methodologies underlying the development of cost-of-illness models and the impact of using different methods to conduct cost-of-illness studies on study results.
Title of Dissertation: “An Examination of Methodologies for Conducting Cost of Illness Studies: In the Context of Prostate Cancer.”
Degrees Received: Pharm.D., University of Florida, May 2001 (High Honors)
Honors Received: 2001, Rho Chi-Schering-Plough-AFPE First Year Graduate Scholarship; 2001, University of Florida Alumni Fellowship; 2001-1997, Dean’s List; 1999, Rho Chi Pharmacy Honor Society
AFPE Award JANSSEN PHARMACEUTICA-AFPE Fellowship in Social & Administrative Sciences (Pharmacoeconomics)

JOSHUA THORPE
University of North Carolina at Chapel Hill School of Pharmacy
Major: Social & Administrative Sciences
GPA: N/A
Expected Graduation: May 2005
Focus of Research: Examining the relationship between community and medical care resources and associated access/adherence to HIV/AID health services and medications. The goal is to reveal potential barriers to achieving high levels of adherence and provide targeted guidance for future interventions. A geographic information system (GIS) will be created to examine the effects of distance to health care, rurality, and community characteristics on access to HIV health care services, utilization, and medication adherence.
Title of Dissertation: “Community and geographic barriers to medication access and adherence in rural persons living with HIV/AIDS.”
Degrees Received: M.P.H., Epidemiology, George Washington University, December 2000
B.A., Neuroscience, Hamilton College, May 1995
Honors Received: 2003, NIH National Research Service Award – pre-doctoral; 2002, Best student research abstract/presentation: Am. Public Health; 1999-98, Dean’s list – George Washington University Master’s Program; 1995, Department distinction for undergraduate thesis; 1994, Hughes Foundation grant for summer research
AFPE Award  

JOHN W. TOMSHO
University of Michigan College of Pharmacy
Major: Medicinal/Pharmaceutical Chemistry
GPA: 6.98/7.00
Expected Graduation: May 2004
Focus of Research: Determining whether folypolyglutamate synthetase (FPGS) catalyzes the ligations of the glutamate substrates in either a processive or distributive fashion using a combination of biochemical and chemical methods. The synthesis of a radio-labeled alternate substrate will allow the definitive determination of the course of the reaction by allowing a pulse-chase experiment to be carried out.
Title of Dissertation: “Studies into the Reaction Mechanism of Folylpoly-Glutamate Synthetase: Processivity.”
Degrees Received: B.S., Pharmaceutical Chemistry, Philadelphia College of Pharmacy and Science, May 1998
Honors Received: 2001, AFPE Pre-Doctoral Fellowship; 2002-2001, Fred W. Lyons, Jr. Fellowship; 2001, Blake Fellowship; 2000-1998, Chemistry-Biology Interface Fellowship; 1998, Reber Research Award; 1998, De-Lisser Matthews Prize; 1998, American Institute of Chemists Undergraduate Award in Pharmaceutical Chemistry; 1997, American Chemical Society Award for Undergraduate Analytical Chemistry
AFPE Award RICHARD E. FAUST Citation Fellowship in the Pharmaceutical Sciences

DONAH TRAN
State University of New York at Buffalo School of Pharmacy and Pharmaceutical Sciences
Major: Pharmaceutical Sciences
GPA: 3.85/4.00
Expected Graduation: June 2004
Focus of Research: The focus of my research is to understand the mechanism of organic nitrites toxicity. Specifically, we examined in vivo nitrite effect on expression of cancer/angiogenesis related gene.
Title of Dissertation: “Isobutyl Nitrite-Induced Tumor Growth-An Investigation of its Mechanism of Action.”
Degrees Received: B.S., Pharmacy, State University of New York at Buffalo, May 1996
Honors Received: 2003-2001, Merck’s Graduate Fellowship; 2002, Who’s Who Among Students in American Universities; 2001, Outstanding Teaching Assistant Award; 1997, Tops Pharmacy Employee of the Month; 1995, Pharmacy Alumni Associate Award; 1992, Ciba-Geigy High School Award
AFPE Award  

MEGHANA TRIVEDI
University of Houston College of Pharmacy
Major: Pharmacology/Toxicology
GPA: 4.00/4.00
Expected Graduation: May 2004
Focus of Research: To study the role of insulin resistance in diminished dopamine D1A receptor signaling and function in the kidney, contributing to development of hypertension in obesity.
Title of Dissertation: “Renal Dopamine D1A Receptor Signaling In Obesity And Insulin Resistance.”
Degrees Received: None
Honors Received: 2003-98, Dean’s honor list; 2003, Sigma Xi Research Poster Award; 2002, Makhtoob Alam Graduate Student Scholarship; 2001-98, Dean’s Scholarship
AFPE Award  

JANNINE G. TRUONG
University of Utah College of Pharmacy
Major: Pharmacology/Toxicology
GPA: 3.85/4.00
Expected Graduation: May 2004
Focus of Research: Dissertation research is focused on investigation dopamine receptor subtypes involved in regulation of vesicular monoamine transporter-2 (VMAT-2) function, determining the mechanism whereby the dopamine receptor subtypes regulate VMAT-2 function and examining its neuroprotective potential in the rat model of methamphetamine neurotoxicity.
Title of Dissertation: “Dopamine Receptor Regulation of Vesicular Monoamine Transporter-2 Function.”
Degrees Received: M.S., Neurobiology, University of Texas-San Antonio, May 2000
B.S., Biology, University of Texas-San Antonio, May 1998
B.S., Chemistry, University of Texas at Austin, December 1996
Honors Received: 2002, American Pyschological Assoc-Honorable Mention; 2002, AFPE Pre-Doctoral Fellowship; 2002, University of Utah Graduate Travel Award; 2000, UTSA Research Scientist Award; 1999, UTSA Research Award; 1999, UTSA Small Grant Award; 1999, UTSA Travel Award; 1996-1994, Hemphill-Gilmore Scholarship; 1995, Hoechst Celanese Scholarship; 1993, University Co-op Scholarship; 1993-1991, Tams Gifted Program
AFPE Award SIR HENRY S. WELLCOME Memorial Fellowship in Pharmacology/Toxicology

COLIN T. WALSH
Ohio State University College of Pharmacy
Major: Pharmaceutics
GPA: 3.65/4.00
Expected Graduation: January 2004
Focus of Research: This research focuses on research reports that fibroblast growth factors 1&2 induce broad-spectrum resistance to anti-cancer drugs, and that suramin (an FGF inhibitor) reverses this resistance. Therefore, my thesis work is focused on improving our understanding of the mechanisms of the FGF-induced resitance and the molecular pharmacodynamics of suramin. I have used bioinformatic tools to ouline the signaling the pathways responsible for the FGF-induced resistance. At present, and I am implementing custom quantitative image analysis tools to analyze FGF levels in patient tumors to determine the relationship between intratumoral FGF levels and chemosensitivity.
Title of Dissertation: “Molecular Pharmacodynamics of Cancer Chemotherapy: Fibroblast Growth Factor Inhibitors as Chemosensitizers.”
Degrees Received: B.S., Chemical Engineering, University of Kentucky, May 1999
Honors Received: 2002-2001, AFPE Pre-doctoral Fellowship; 2000, Outstanding Teaching Assistant Award (Winter & Spring); 1999, College of Engineering Dean’s List (3-semesters); 1999, Omega Chi Epsilon Engineering Honor Society
AFPE Award ABBOTT LABORATORIES FUND-AFPE Fellowship in Pharmaceutics

EMILY C. WARE
University of Georgia College of Pharmacy
Major: Pharmaceutics
GPA: 4.00/4.00
Expected Graduation: May 2004
Focus of Research: Investigations into automated procedures in Preformulation development of different salts of the antidepressant drug Trazodone, and testing using DSC, powder x-ray diffraction, and hygroscopic, density, surface area, particle size analyses, and pH-solubililtiy to determine an optimum salt for a potential sustained or controlled release product.
Title of Dissertation: “Synthesis of Novel Polyster Drug Conjugates and Automated Approaches to Preformulation Development and Salt Selection.”
Degrees Received: B.S., Chemical Engineering, Virginia Polytechnic Institute & State University, December 1997
Honors Received: 2002, AFPE Pre-Doctoral Fellowship; 2002, Excellence in Teaching Award; 2001-2000, Dean’s List; 1997, Engineer in Training Award
AFPE Award NOVARTIS-AFPE Fellowship in Manufacturing/Industrial Pharmacy

AMBER M. YOUNG
University of Kansas School of Pharmacy
Major: Pharmaceutics
GPA: 3.95/4.00
Expected Graduation: August 2004
Focus of Research: My research focuses on the expression, function, and regulation of efflux transporters in the human placenta. In particular, I am examining the role of progesterone and other pregnancy-related hormones in the modulation of these transporters.
Title of Dissertation: “Characterization of Efflux Transporters of the Human Trophoblast.”
Degrees Received: M.S., Pharmaceutical Chemistry, University of Kansas, January 2002
B.S., Chemical Engineering, University of Missouri-Rolla
Honors Received: 2003-2001, NIGMS Biotechnology Training Grant; 2001, PGSRM Poster Award; 2001, Iota Sigma Pi (honors women in chemistry); Tau Beta Pi (engineering honor fraternity)
AFPE Award  

CHRISTOPHER R. YOUNG
University of Texas at Austin College of Pharmacy
Major: Pharmaceutics
GPA: 3.90/4.00
Expected Graduation: May 2004
Focus of Research: Hot-melt extrusion, a widely applied processing technique used in the plastics industry to produce tubes, pipes, wires, and films, is becoming an area of interest in pharmaceutical research. This method can be used to prepare granules, sustained-release tablets, and transdermal drug delivery systems. The purpose of this research is to develop and to characterize a hot-melt extrusion process to manufacture spherical pellets.
Title of Dissertation: “Properties of Spherical Pellets Produced by Hot-Melt Extrusion and Spheronization.”
Degrees Received: B.S., Pharmacy, University of Texas at Austin, May 1999
Honors Received: UT Competitive Graduate Scholarship; 2002-2001, AFPE Pre-Doctoral Fellowship; 1999, Rho Chi-Schering Plough-AFPE First Year Graduate Scholarship; 1999, Pfizer Outstanding Leader Award; 1999, Basic Sciences Outstanding Student Award
AFPE Award NACDS-AFPE Association Fellowship in the Pharmaceutical Sciences

JENNICA ZARO
University of Texas at Austin
Major: Pharmaceutical Sciences
GPA: 3.8/4.0
Expected Graduation: May 2005
Focus of Research: This research project is focused on the mechanism of transport cationic oligoarginine peptides and the limitations of the transport properties for efficient transduction delivery. Through the experimental techniques described in this project, the goal is to develop a rational drug design method to use oligoarginine and other cationic oligopeptides as carriers ot dliver bioactive macromolecules into the cytosol.
Title of Dissertation: “Cationic Peptides: Transport Mechanism and Use as a Drug Delivery System.”
Degrees Received: B.S. Chemistry, Richard Stockton College of New Jersey, May 1998
Honors Received: 2003-2002 Teaching/Research Assistantship; 1998, Outstanding Senior Student in Chemistry; 1998-1995, Dean’s List
AFPE Award  

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